{
  "id": 7779,
  "label": "gastric mucosa-associated lymphoid tissue lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006226",
  "properties": {
    "xrefs": [
      "EFO:1000274",
      "GARD:0024340",
      "MEDGEN:232547",
      "NCIT:C5266",
      "UMLS:C1333782"
    ],
    "synonyms": [
      "MALT lymphoma of stomach",
      "MALT lymphoma of the stomach",
      "MALToma of stomach",
      "MALToma of the stomach",
      "gastric MALT lymphoma",
      "gastric MALToma",
      "gastric mucosa-associated lymphoid tissue lymphoma",
      "primary MALT lymphoma of stomach",
      "primary MALT lymphoma of the stomach",
      "primary gastric B-cell MALT lymphoma",
      "primary gastric MALT lymphoma",
      "stomach MALT lymphoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A low grade, indolent B-cell lymphoma, usually associated with Helicobacter pylori infection. Morphologically it is characterized by a dense mucosal atypical lymphocytic (centrocyte-like cell) infiltrate with often prominent lymphoepithelial lesions and plasmacytic differentiation. Approximately 40% of gastric MALT lymphomas carry the t(11;18)(q21;q21). Such cases are resistant to Helicobacter pylori therapy."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7558,
      "label": "spleen cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3023,
        4587,
        22946
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:672",
          "EFO:0007491",
          "GARD:0024265",
          "ICD10CM:C26.1",
          "MEDGEN:102271",
          "MESH:D013160",
          "NCIT:C3539",
          "SCTID:127230005",
          "UMLS:C0153470",
          "icd11.foundation:347078862"
        ],
        "synonyms": [
          "spleen neoplasm",
          "splenic neoplasm",
          "cancer of spleen",
          "cancer of the spleen",
          "malignant neoplasm of spleen",
          "malignant neoplasm of the spleen",
          "malignant spleen neoplasm",
          "malignant splenic neoplasm",
          "malignant splenic tumor",
          "malignant splenic tumour",
          "malignant tumor of spleen",
          "malignant tumor of the spleen",
          "malignant tumour of the spleen",
          "spleen cancer",
          "splenic cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the spleen"
      },
      "child_count": 15,
      "reference_id": "MONDO:0005966"
    },
    {
      "id": 9011,
      "label": "MALT lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6694,
        17884
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050909",
          "EFO:0000191",
          "GARD:0006485",
          "ICD10CM:C88.4",
          "ICD9:202.80",
          "ICDO:9699/3",
          "MEDGEN:66942",
          "MedDRA:10060707",
          "NCIT:C3898",
          "OMIM:137245",
          "ONCOTREE:EMALT",
          "Orphanet:52417",
          "SCTID:277622004",
          "UMLS:C0242647",
          "Wikipedia:MALT_lymphoma"
        ],
        "synonyms": [
          "Extranodal marginal zone B-cell lymphoma",
          "Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue",
          "Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma)",
          "Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue",
          "Immunocytoma",
          "MALT lymphoma",
          "MALT-lymphoma",
          "MALToma",
          "lymphoma of mucosa-associated lymphoid tissue",
          "lymphoma, MALT, somatic",
          "mucosa-associated lymphatic tissue lymphoma",
          "mucosa-associated lymphoid tissue lymphoma",
          "extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)",
          "familial primary gastric lymphoma",
          "gastric lymphoma, primary",
          "lymphoma, mucosa-associated lymphoid type"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes (centrocyte-like cells). The gastrointestinal tract is the most common site of involvement. Other common sites of involvement include lung, head and neck, ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated with the presence of H. pylori infection. (WHO, 2001)"
      },
      "child_count": 15,
      "reference_id": "MONDO:0007650"
    },
    {
      "id": 18536,
      "label": "hereditary gastric cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021758",
          "MEDGEN:1843054",
          "Orphanet:423776",
          "UMLS:C5680075"
        ],
        "synonyms": [
          "hereditary cancer of stomach",
          "hereditary gastric cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Hereditary gastric cancer refers to the occurrence of gastric cancer in a familial context and is described as two or more cases of gastric cancer in first or second degree relatives with at least one case diagnosed before the age of 50. Familial clustering is observed in 10% of all cases of gastric cancer, and includes hereditary diffuse gastric cancer (early onset diffuse-type gastric cancer), gastric adenocarcinoma and proximal polyposis of the stomach and familial intestinal gastric cancer (familial clustering of intestinal type gastric adenocarcinoma). Hereditary gastric cancer can also occur in other hereditary cancer syndromes such as Lynch syndrome, Li-Fraumeni syndrome, familial adenomatous polyposis and juvenile polyposis syndrome."
      },
      "child_count": 8,
      "reference_id": "MONDO:0018502"
    },
    {
      "id": 23066,
      "label": "gastric non-hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3314,
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0000089",
          "MEDGEN:232549",
          "NCIT:C27235",
          "SCTID:448709005",
          "UMLS:C1333784"
        ],
        "synonyms": [
          "gastric non-Hodgkin lymphoma",
          "gastric non-Hodgkin's lymphoma",
          "non-Hodgkin lymphoma of stomach",
          "non-Hodgkin's lymphoma of stomach",
          "non-Hodgkin's lymphoma of the stomach",
          "primary gastric non-Hodgkin's lymphoma",
          "stomach non-Hodgkin lymphoma",
          "lymphoma, gastric non Hodgkins type",
          "non-Hodgkins gastric lymphoma",
          "stomach lymphoma, non-Hodgkins type"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An extranodal non-Hodgkin lymphoma that arises from the stomach with the bulk of the mass located in the stomach. The vast majority of cases are diffuse large B-cell lymphomas and B-cell lymphomas of the mucosa-associated lymphoid tissue."
      },
      "child_count": 4,
      "reference_id": "MONDO:0042493"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7558,
      "label": "spleen cancer"
    },
    {
      "id": 9011,
      "label": "MALT lymphoma"
    },
    {
      "id": 18536,
      "label": "hereditary gastric cancer"
    },
    {
      "id": 23066,
      "label": "gastric non-hodgkin lymphoma"
    }
  ]
}