{
  "id": 7784,
  "label": "gastrointestinal hamartoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006231",
  "properties": {
    "xrefs": [
      "EFO:1000280",
      "MEDGEN:474435",
      "NCIT:C96475",
      "UMLS:C3272802"
    ],
    "synonyms": [
      "gastrointestinal hamartoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A non-neoplastic, hamartomatous polyp that arises from the stomach, small intestine, and large intestine. This group includes the juvenile polyps and Peutz-Jeghers polyps."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 7993,
      "label": "hamartoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3462",
          "EFO:1000634",
          "HP:0010566",
          "ICD9:759.6",
          "MEDGEN:6713",
          "MESH:D006222",
          "NCIT:C3075",
          "SCTID:400006008",
          "UMLS:C0018552"
        ],
        "synonyms": [
          "hamartoma",
          "hamartoma (disease)"
        ],
        "definition": "A benign and excessive tumor-like growth of mature cells and normal tissues which grow in a disorganized pattern."
      },
      "child_count": 13,
      "reference_id": "MONDO:0006499"
    },
    {
      "id": 20434,
      "label": "digestive system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0008549",
          "MEDGEN:8398",
          "MESH:D005770",
          "NCIT:C3052",
          "UMLS:C0012243"
        ],
        "synonyms": [
          "GI neoplasm",
          "GI system neoplasm",
          "GI system tumor",
          "GI system tumour",
          "GI tumor",
          "GI tumour",
          "digestive neoplasm",
          "digestive system neoplasm (disease)",
          "digestive system tumor",
          "digestive system tumour",
          "digestive tumor",
          "digestive tumour",
          "gastrointestinal neoplasm",
          "gastrointestinal system neoplasm",
          "gastrointestinal system tumor",
          "gastrointestinal system tumour",
          "gastrointestinal tumor",
          "gastrointestinal tumour",
          "neoplasm of GI system",
          "neoplasm of digestive system",
          "neoplasm of gastrointestinal system",
          "neoplasm of the GI system",
          "neoplasm of the digestive system",
          "neoplasm of the gastrointestinal system",
          "tumor of GI system",
          "tumor of digestive system",
          "tumor of gastrointestinal system",
          "tumor of the GI system",
          "tumor of the digestive system",
          "tumor of the gastrointestinal system",
          "tumour of GI system",
          "tumour of digestive system",
          "tumour of gastrointestinal system",
          "tumour of the GI system",
          "tumour of the digestive system",
          "tumour of the gastrointestinal system"
        ],
        "definition": "A neoplasm (disease) that involves the digestive system."
      },
      "child_count": 23,
      "reference_id": "MONDO:0021223"
    },
    {
      "id": 21327,
      "label": "gastrointestinal polyp",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151,
        6807
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:219797",
          "NCIT:C35516",
          "UMLS:C1257915"
        ],
        "synonyms": [
          "GI polyp",
          "gastrointestinal polyp",
          "gastrointestinal tract polyp"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A polypoid tumor that arises from any part of the gastrointestinal tract and protrudes into the lumen. Representative examples include adenomatous polyps, hyperplastic polyps, and hamartomatous polyps."
      },
      "child_count": 4,
      "reference_id": "MONDO:0024292"
    }
  ],
  "children": [
    {
      "id": 7721,
      "label": "colorectal hamartoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7022,
        7784,
        20546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000193",
          "MEDGEN:474434",
          "NCIT:C96474",
          "UMLS:C3272801"
        ],
        "synonyms": [
          "colorectal hamartoma",
          "colorectum hamartoma (disease)",
          "large intestinal hamartoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A non-neoplastic, hamartomatous polyp that arises from the colon and rectum. This group includes the juvenile polyp, Peutz-Jeghers polyp, and Cowden-associated polyp."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006160"
    },
    {
      "id": 7777,
      "label": "gastric hamartomatous polyp",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7784,
        20326
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000271",
          "MEDGEN:90961",
          "NCIT:C4373",
          "SCTID:235685007",
          "UMLS:C0341225"
        ],
        "synonyms": [
          "gastric hamartomatous polyp",
          "hamartoma of stomach",
          "hamartoma of the stomach",
          "stomach hamartoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A non-neoplastic polyp that arises from the stomach and is characterized by the presence of connective tissue stroma overgrowth and cystic formations."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006224"
    },
    {
      "id": 7805,
      "label": "juvenile polyp",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7784
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000310",
          "MEDGEN:113158",
          "NCIT:C3826",
          "UMLS:C0221273"
        ],
        "synonyms": [
          "juvenile polyp",
          "retention polyp"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A non-neoplastic hamartomatous polyp that arises from the stomach and intestinal tract. It is characterized by the presence of tortuous and cystically dilated glands, edematous changes, and inflammation."
      },
      "child_count": 1,
      "reference_id": "MONDO:0006258"
    },
    {
      "id": 7890,
      "label": "Peutz-Jeghers polyp",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7784
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000470",
          "MEDGEN:141582",
          "NCIT:C4733",
          "UMLS:C0456487"
        ],
        "synonyms": [
          "Peutz Jeghers polyp",
          "Peutz-Jeghers polyp"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A hamartomatous polyp that occurs in the stomach, small and large intestines, and rarely within the esophagus, nasopharynx and the urinary tract. The Peutz-Jeghers polyps are grossly lobulated and dark. Microscopically, they have a central core of smooth muscle covered by mucosa. The smooth muscle shows tree-like branching. The question of whether or not the Peutz-Jeghers polyp is precancerous is a matter of controversy. The loss of heterozygosity on chromosome 19p (where the responsible gene LKB1 is located) suggests that the increased risk of malignancy may be due to malignant transformation from hamartoma to adenocarcinoma. --2002"
      },
      "child_count": 1,
      "reference_id": "MONDO:0006365"
    }
  ],
  "roots": [
    {
      "id": 7993,
      "label": "hamartoma"
    },
    {
      "id": 20434,
      "label": "digestive system neoplasm"
    },
    {
      "id": 21327,
      "label": "gastrointestinal polyp"
    }
  ]
}