{
  "id": 7788,
  "label": "granular cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006235",
  "properties": {
    "xrefs": [
      "DOID:2411",
      "EFO:1000284",
      "GARD:0009618",
      "ICD9:215.9",
      "ICDO:9580/0",
      "MEDGEN:88345",
      "MESH:C535558",
      "MESH:D016586",
      "NCIT:C3474",
      "ONCOTREE:GCT",
      "SCTID:404035005",
      "UMLS:C0085167"
    ],
    "synonyms": [
      "Abrikossoff tumor",
      "Abrikossoff tumour",
      "Abrikossoff's tumor",
      "Abrikossoff's tumour",
      "granular cell myoblastoma",
      "granular cell neoplasm",
      "granular cell nerve sheath tumor",
      "granular cell nerve sheath tumour",
      "granular cell schwannoma",
      "granular cell tumor",
      "granular cell tumor (morphologic abnormality)",
      "granular cell tumour (morphologic abnormality)",
      "granular cell tumor NOS (morphologic abnormality)",
      "granular cell tumour NOS (morphologic abnormality)",
      "neoplasm of granular cell",
      "Abrikosoff's granulous cell tumor",
      "Abrikosoff's granulous cell tumour",
      "Abrikosoff's tumor",
      "Abrikosoff's tumour",
      "Abrikosov's tumor",
      "Abrikosov's tumour",
      "Abrikosov’s tumor",
      "Abrikosov’s tumour",
      "GCT",
      "giant granulocellular Abrikosov's tumor",
      "giant granulocellular Abrikosov's tumour",
      "malignant variant of Abrikosov's tumor",
      "malignant variant of Abrikosov's tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "An unusual benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. It was originally thought to be a tumor originating from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells. It affects females more often than males and it usually presents as a solitary mass. A minority of patients have multiple tumors. It can arise from many anatomic sites including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 4613,
      "label": "nerve sheath neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3627,
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3193",
          "GARD:0023161",
          "MEDGEN:64639",
          "MESH:D018317",
          "NCIT:C4972",
          "ONCOTREE:NST",
          "UMLS:C0206727"
        ],
        "synonyms": [
          "neoplasm of nerve sheath",
          "neoplasm of the nerve sheath",
          "nerve sheath neoplasm",
          "nerve sheath tumor",
          "tumor of nerve sheath",
          "tumour of nerve sheath"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from the perineural cells in the sheaths surrounding the nerves. Representative examples include neurofibroma, schwannoma, and malignant peripheral nerve sheath tumor."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002547"
    }
  ],
  "children": [
    {
      "id": 4403,
      "label": "cutaneous granular cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4409,
        7788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2410",
          "GARD:0023107",
          "ICD9:215.9",
          "MEDGEN:138035",
          "NCIT:C5617",
          "SCTID:254763007",
          "UMLS:C0346060"
        ],
        "synonyms": [
          "cutaneous granular cell neoplasm",
          "cutaneous granular cell tumor",
          "granular cell neoplasm of skin",
          "granular cell neoplasm of the skin",
          "granular cell skin tumor",
          "granular cell skin tumour",
          "granular cell tumor of skin",
          "granular cell tumor of the skin",
          "granular cell tumor of zone of skin",
          "granular cell tumour of the skin",
          "granular cell tumour of zone of skin",
          "skin granular cell neoplasm",
          "zone of skin granular cell tumor",
          "zone of skin granular cell tumour",
          "skin granular cell tumor",
          "skin granular cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A granular cell tumor that involves the zone of skin."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002291"
    },
    {
      "id": 4566,
      "label": "breast granular cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7788,
        20340
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3011",
          "GARD:0023147",
          "MEDGEN:307309",
          "NCIT:C40400",
          "UMLS:C1511312"
        ],
        "synonyms": [
          "breast granular cell tumor",
          "granular cell tumor of breast",
          "granular cell tumour of breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A usually benign neoplasm that arises from the breast. It presents as a single, firm, and painless mass. It is characterized by the presence of neoplastic cells with eosinophilic granular cytoplasm."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002487"
    },
    {
      "id": 5195,
      "label": "benign granular cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7788,
        23665
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5039",
          "GARD:0023421",
          "MEDGEN:44550",
          "NCIT:C3252",
          "UMLS:C0027043"
        ],
        "synonyms": [
          "benign granular cell myoblastoma",
          "benign granular cell neoplasm",
          "benign granular cell tumor",
          "granular cell tumor, benign",
          "myoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A granular cell tumor that is confined to the site of origin, without metastatic potential."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003250"
    },
    {
      "id": 5196,
      "label": "esophageal granular cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7788,
        20522
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5040",
          "GARD:0023422",
          "MEDGEN:234228",
          "NCIT:C5700",
          "UMLS:C1333448",
          "icd11.foundation:1070074406"
        ],
        "synonyms": [
          "esophageal granular cell myoblastoma",
          "esophageal granular cell neoplasm",
          "esophageal granular cell tumor",
          "esophagus granular cell tumor",
          "granular cell esophageal tumor",
          "granular cell esophageal tumour",
          "granular cell esophagus myoblastoma",
          "granular cell esophagus neoplasm",
          "granular cell esophagus tumor",
          "granular cell myoblastoma of esophagus",
          "granular cell myoblastoma of oesophagus",
          "granular cell myoblastoma of the esophagus",
          "granular cell myoblastoma of the oesophagus",
          "granular cell neoplasm of esophagus",
          "granular cell neoplasm of oesophagus",
          "granular cell neoplasm of the esophagus",
          "granular cell neoplasm of the oesophagus",
          "granular cell oesophagus myoblastoma",
          "granular cell oesophagus neoplasm",
          "granular cell oesophagus tumour",
          "granular cell tumor of esophagus",
          "granular cell tumor of the esophagus",
          "granular cell tumour of oesophagus",
          "granular cell tumour of the oesophagus",
          "oesophagus granular cell tumour",
          "malignant granular cell esophageal tumor",
          "malignant granular cell esophageal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A tumor that usually presents with small nodules or small sessile polyps, predominantly in the distal esophagus. Histologically, it is composed of sheets of oval to polygonal cells with a small central nucleus and abundant granular cytoplasm. This is usually a benign tumor. (WHO, 2000) -- 2003"
      },
      "child_count": 0,
      "reference_id": "MONDO:0003251"
    },
    {
      "id": 5197,
      "label": "granular cell cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7788,
        20329,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5042",
          "GARD:0023423",
          "ICD9:171.9",
          "ICDO:9580/3",
          "MEDGEN:87276",
          "NCIT:C4336",
          "SCTID:404041003",
          "UMLS:C0334618"
        ],
        "synonyms": [
          "granular cell tumor, malignant",
          "granular cell tumor, malignant (morphologic abnormality)",
          "malignant granular cell myoblastoma",
          "malignant granular cell neoplasm",
          "malignant granular cell tumor",
          "malignant granular cell tumour",
          "myoblastoma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An uncommon granular cell tumor which may metastasize to other anatomic sites. Morphologic characteristics include the presence of spindling neoplastic cells, necrosis, extensive pleomorphism, prominent nucleoli, and increased mitiotic activity."
      },
      "child_count": 12,
      "reference_id": "MONDO:0003252"
    },
    {
      "id": 5198,
      "label": "vulvar granular cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7788,
        20293
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5043",
          "GARD:0023424",
          "MEDGEN:276992",
          "NCIT:C40328",
          "UMLS:C1520083"
        ],
        "synonyms": [
          "granular cell tumor of mammalian vulva",
          "granular cell tumour of mammalian vulva",
          "mammalian vulva granular cell tumor",
          "mammalian vulva granular cell tumour",
          "vulvar granular cell tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A usually benign granular cell tumor that arises from the vulva."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003253"
    },
    {
      "id": 5200,
      "label": "mediastinal granular cell myoblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7788,
        20542
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5046",
          "GARD:0023426",
          "MEDGEN:235309",
          "NCIT:C6601",
          "UMLS:C1334656"
        ],
        "synonyms": [
          "granular cell myoblastoma of mediastinum",
          "granular cell myoblastoma of the mediastinum",
          "granular cell neoplasm of mediastinum",
          "granular cell neoplasm of the mediastinum",
          "granular cell tumor of mediastinum",
          "granular cell tumor of the mediastinum",
          "granular cell tumour of mediastinum",
          "granular cell tumour of the mediastinum",
          "mediastinal granular cell myoblastoma",
          "mediastinal granular cell neoplasm",
          "mediastinal granular cell tumor",
          "mediastinal granular cell tumour",
          "mediastinum granular cell tumor",
          "mediastinum granular cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An exceptionally rare, generally benign, granular cell tumor that arises from the mediastinum. All the reported cases were located in the posterior mediastinum."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003255"
    },
    {
      "id": 5201,
      "label": "neurohypophysis granular cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5202,
        7788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5047",
          "EFO:1000285",
          "GARD:0023427",
          "ICDO:9582/0",
          "MEDGEN:232255",
          "NCIT:C7017",
          "SCTID:699331002",
          "UMLS:C1333873"
        ],
        "synonyms": [
          "granular cell tumor of Neurohypophysis",
          "granular cell tumor of neurohypophysis",
          "granular cell tumor of the Neurohypophysis (WHO grade I)",
          "granular cell tumor of the neurohypophysis",
          "granular cell tumor of the posterior pituitary gland",
          "granular cell tumour of Neurohypophysis",
          "granular cell tumour of neurohypophysis",
          "granular cell tumour of the Neurohypophysis (WHO grade I)",
          "granular cell tumour of the neurohypophysis",
          "granular cell tumour of the posterior pituitary gland",
          "neurohypophysis granular cell tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A generally benign intrasellar and/or suprasellar mass arising from the neurohypophysis or infundibulum. It is composed of nests of large cells with granular, eosinophilic cytoplasm due to abundant intracytoplasmic lysosomes. It generally has a slow progression and lacks invasive growth. (Adapted from WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0003256"
    },
    {
      "id": 16342,
      "label": "congenital epulis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4427,
        5328,
        7788,
        7941,
        7993,
        20327,
        20677
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7280",
          "DOID:8303",
          "GARD:0020016",
          "MEDGEN:83962",
          "MESH:D005887",
          "NCIT:C4675",
          "Orphanet:157826",
          "SCTID:360525006",
          "UMLS:C0376319",
          "icd11.foundation:1616915738"
        ],
        "synonyms": [
          "Neumann tumor",
          "Neumann tumour",
          "congenital epulis",
          "congenital gingival cell tumor",
          "congenital gingival cell tumour",
          "congenital granular cell tumor",
          "congenital granular cell tumour",
          "gingival granular cell tumor",
          "gingival granular cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A congenital gingival tumor that occurs along the alveolar ridge of the maxilla. It usually affects female infants. The histogenesis is unknown. Morphologically, it is characterized by the presence of large cells with eosinophilic granular cytoplasm. Complete surgical resection is curative."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015528"
    }
  ],
  "roots": [
    {
      "id": 4613,
      "label": "nerve sheath neoplasm"
    }
  ]
}