{
  "id": 7790,
  "label": "growth hormone-producing pituitary gland adenoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006238",
  "properties": {
    "xrefs": [
      "DOID:6255",
      "EFO:1000287",
      "GARD:0016850",
      "MEDGEN:82999",
      "NANDO:1200385",
      "NANDO:1200386",
      "NCIT:C7461",
      "Orphanet:96256",
      "SCTID:254957009",
      "UMLS:C0278864"
    ],
    "synonyms": [
      "GH cell adenoma",
      "Somatotrophinoma",
      "growth hormone producing adenoma of pituitary",
      "growth hormone producing adenoma of pituitary gland",
      "growth hormone producing adenoma of the pituitary gland",
      "growth hormone producing pituitary adenoma",
      "growth hormone producing pituitary gland adenoma",
      "growth hormone secreting adenoma of pituitary",
      "growth hormone secreting adenoma of pituitary gland",
      "growth hormone secreting adenoma of the pituitary",
      "growth hormone secreting adenoma of the pituitary gland",
      "growth hormone secreting pituitary gland adenoma",
      "growth hormone-producing adenoma",
      "growth hormone-producing pituitary gland adenoma",
      "somatotrope adenoma",
      "somatotropic adenoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An adenoma of the anterior lobe of the pituitary gland that produces growth hormone. The vast majority of cases are hormonally functioning and are associated with either gigantism or acromegaly."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 7896,
      "label": "pituitary gland adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6714,
        17888
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3829",
          "EFO:1000478",
          "GARD:0019680",
          "ICDO:8272/0",
          "MEDGEN:45933",
          "MedDRA:10035079",
          "NANDO:2200095",
          "NCIT:C3329",
          "ONCOTREE:PTAD",
          "Orphanet:99408",
          "SCTID:254956000",
          "UMLS:C0032000"
        ],
        "synonyms": [
          "adenoma of pituitary",
          "adenoma of pituitary gland",
          "adenoma of the pituitary",
          "adenoma of the pituitary gland",
          "adenoma, anterior lobe pituitary gland, benign",
          "pituitary adenoma",
          "pituitary gland adenoma",
          "PTAD"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-metastasizing tumor that arises from the adenohypophysial cells of the anterior lobe of the pituitary gland. The tumor can be hormonally functioning or not. The diagnosis can be based on imaging studies and/or radioimmunoassays. Due to its location in the sella turcica, expansion of the tumor mass can impinge on the optic chiasm or involve the temporal lobe, third ventricle and posterior fossa A frequently associated physical finding is bitemporal hemianopsia which may progress to further visual loss."
      },
      "child_count": 18,
      "reference_id": "MONDO:0006373"
    },
    {
      "id": 19647,
      "label": "growth hormone-producing pituitary gland neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7265,
        17888
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025150",
          "MEDGEN:866320",
          "NCIT:C7911",
          "UMLS:C4018860"
        ],
        "synonyms": [
          "Growth hormone-producing pituitary gland tumor",
          "Growth hormone-producing pituitary gland tumour",
          "growth hormone producing neoplasm of pituitary",
          "growth hormone producing neoplasm of pituitary gland",
          "growth hormone producing neoplasm of the pituitary",
          "growth hormone producing neoplasm of the pituitary gland",
          "growth hormone producing pituitary gland neoplasm",
          "growth hormone producing pituitary gland tumor",
          "growth hormone producing pituitary gland tumour",
          "growth hormone producing pituitary neoplasm",
          "growth hormone producing pituitary tumor",
          "growth hormone producing pituitary tumour",
          "growth hormone producing tumor",
          "growth hormone producing tumor of pituitary",
          "growth hormone producing tumor of pituitary gland",
          "growth hormone producing tumor of the pituitary",
          "growth hormone producing tumor of the pituitary gland",
          "growth hormone producing tumour",
          "growth hormone producing tumour of pituitary",
          "growth hormone producing tumour of pituitary gland",
          "growth hormone producing tumour of the pituitary",
          "growth hormone producing tumour of the pituitary gland",
          "growth hormone secreting neoplasm of pituitary",
          "growth hormone secreting neoplasm of pituitary gland",
          "growth hormone secreting neoplasm of the pituitary",
          "growth hormone secreting neoplasm of the pituitary gland",
          "growth hormone secreting pituitary gland neoplasm",
          "growth hormone secreting pituitary gland tumor",
          "growth hormone secreting pituitary gland tumour",
          "growth hormone secreting pituitary neoplasm",
          "growth hormone secreting pituitary tumor",
          "growth hormone secreting pituitary tumour",
          "growth hormone secreting tumor of pituitary",
          "growth hormone secreting tumor of pituitary gland",
          "growth hormone secreting tumor of the pituitary",
          "growth hormone secreting tumor of the pituitary gland",
          "growth hormone secreting tumour of pituitary",
          "growth hormone secreting tumour of pituitary gland",
          "growth hormone secreting tumour of the pituitary",
          "growth hormone secreting tumour of the pituitary gland",
          "growth hormone-producing pituitary gland neoplasm",
          "pituitary gland somatotropinoma",
          "pituitary somatotropinoma",
          "somatotroph neoplasm",
          "somatotroph tumor",
          "somatotroph tumour",
          "somatotropinoma",
          "somatotropinoma of pituitary",
          "somatotropinoma of pituitary gland",
          "somatotropinoma of the pituitary",
          "somatotropinoma of the pituitary gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenoma or carcinoma of the anterior lobe of the pituitary gland that produces growth hormone."
      },
      "child_count": 6,
      "reference_id": "MONDO:0019927"
    }
  ],
  "children": [
    {
      "id": 8471,
      "label": "growth hormone secreting pituitary adenoma 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7790,
        18043
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0112009",
          "GARD:0024520",
          "MEDGEN:1618709",
          "OMIM:102200",
          "UMLS:C4538355"
        ],
        "synonyms": [
          "pituitary adenoma 1, multiple types, autosomal dominant, somatic mutation",
          "pituitary adenoma predisposition, autosomal dominant, somatic mutation",
          "pituitary adenoma, growth hormone-secreting, type 1",
          "PAGH1",
          "PITA1",
          "Somatotrophinoma, familial",
          "acromegaly due to pituitary adenoma 1",
          "familial isolated pituitary adenoma syndrome",
          "isolated familial somatotropinoma",
          "pituitary adenoma 1, multiple types",
          "pituitary adenoma predisposition",
          "pituitary adenoma, familial isolated",
          "pituitary adenoma, growth hormone-secreting, 1",
          "somatotropinoma, familial isolated"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0007052"
    }
  ],
  "roots": [
    {
      "id": 7896,
      "label": "pituitary gland adenoma"
    },
    {
      "id": 19647,
      "label": "growth hormone-producing pituitary gland neoplasm"
    }
  ]
}