{
  "id": 7791,
  "label": "head and neck paraganglioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006239",
  "properties": {
    "xrefs": [
      "EFO:1000288",
      "GARD:0024345",
      "MEDGEN:232588",
      "NCIT:C5327",
      "UMLS:C1333944"
    ],
    "synonyms": [
      "craniocervical region paraganglioma",
      "head and neck paraganglioma",
      "paraganglioma of craniocervical region",
      "paraganglioma of head and neck",
      "paraganglioma of the head and neck"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A benign or malignant extra-adrenal paraganglioma arising from paraganglia in the head and neck. Representative examples include the carotid body and jugulotympanic paragangliomas."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 2912,
      "label": "paraganglioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4464,
        19314,
        20691,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050773",
          "EFO:1000453",
          "GARD:0022770",
          "ICD9:239.7",
          "ICDO:8680/1",
          "MEDGEN:10571",
          "MESH:D010235",
          "NCIT:C3308",
          "ONCOTREE:PGNG",
          "SCTID:127027008",
          "UMLS:C0030421"
        ],
        "synonyms": [
          "Paraganglionic neoplasm",
          "Paraganglionic tumor",
          "Paraganglionic tumour",
          "neoplasm of paraganglion",
          "neoplasm of the paraganglion",
          "paraganglioma",
          "paragangliomas",
          "paraganglion neoplasm",
          "paraganglion tumor",
          "paraganglion tumour",
          "tumor of paraganglion",
          "tumor of the paraganglion",
          "tumour of paraganglion",
          "tumour of the paraganglion",
          "chemodectoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from paraganglia located along the sympathetic or parasympathetic nerves. Infrequently, it may arise outside the usual distribution of the sympathetic and parasympathetic paraganglia. Tumors arising from the adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas usually display a nesting (Zellballen) growth pattern. There are no reliable morphologic criteria to distinguish between benign and malignant paragangliomas. The only definitive indicator of malignancy is the presence of regional or distant metastases."
      },
      "child_count": 48,
      "reference_id": "MONDO:0000448"
    },
    {
      "id": 7231,
      "label": "head and neck neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005950",
          "ICD9:239.89",
          "MEDGEN:6728",
          "NCIT:C3077",
          "ONCOTREE:HEADNECK",
          "SCTID:255055008",
          "UMLS:C0018671"
        ],
        "synonyms": [
          "craniocervical region neoplasm",
          "craniocervical region neoplasm (disease)",
          "craniocervical region tumor",
          "craniocervical region tumour",
          "head and neck neoplasm",
          "head and neck neoplasm (excluding central nervous system)",
          "head and neck tumor",
          "head and neck tumour",
          "neoplasm of craniocervical region",
          "neoplasm of head and neck",
          "neoplasm of the head and neck",
          "tumor of craniocervical region",
          "tumor of head and neck",
          "tumor of the head and neck",
          "tumour of craniocervical region",
          "tumour of head and neck",
          "tumour of the head and neck"
        ],
        "definition": "A benign or malignant neoplasm that affects the anatomic structures of the head and neck region. Representative examples of benign neoplasms include salivary gland pleomorphic adenoma and nasal cavity papilloma. Representative examples of malignant neoplasms include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma."
      },
      "child_count": 37,
      "reference_id": "MONDO:0005586"
    }
  ],
  "children": [
    {
      "id": 20296,
      "label": "carotid body paraganglioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7791,
        20295
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010598",
          "ICDO:8692/1",
          "MEDGEN:2853",
          "MESH:D002345",
          "NCIT:C2932",
          "UMLS:C0007279"
        ],
        "synonyms": [
          "carotid body paraganglioma",
          "paraganglioma of carotid body",
          "carotid body chemodectoma",
          "carotid body tumor",
          "carotid body tumour",
          "chemodectoma",
          "chemodectoma, undetermined",
          "paraganglioma of the carotid body",
          "tumor of carotid body",
          "tumor of the carotid body",
          "tumour of carotid body",
          "tumour of the carotid body"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant extra-adrenal parasympathetic paraganglioma arising from paraganglia adjacent to or in the bifurcation of the common carotid artery. Most patients present with a slow growing, painless mass in the neck."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021053"
    },
    {
      "id": 20305,
      "label": "jugulotympanic paraganglioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4813,
        7791,
        20295,
        21247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025284",
          "ICD9:239.7",
          "ICDO:8690/1",
          "MEDGEN:4905",
          "NCIT:C3061",
          "SCTID:127030001",
          "UMLS:C0017671"
        ],
        "synonyms": [
          "basicranium parasympathetic paraganglioma",
          "glomus jugulare neoplasm",
          "glomus jugulare tumor",
          "glomus jugulare tumour",
          "jugular body neoplasm",
          "jugular body neoplasm (disease)",
          "jugular body tumor",
          "jugular body tumour",
          "jugular paraganglioma",
          "jugulotympanic paraganglioma",
          "neoplasm of glomus jugulare",
          "neoplasm of jugular body",
          "neoplasm of the glomus jugulare",
          "parasympathetic paraganglioma of basicranium",
          "tumor of glomus jugulare",
          "tumor of jugular body",
          "tumor of the glomus jugulare",
          "tumour of glomus jugulare",
          "tumour of jugular body",
          "tumour of the glomus jugulare",
          "Glomus tumor",
          "Glomus tumour",
          "Paraganglioma - glomus jugulare"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant extra-adrenal parasympathetic paraganglioma arising from paraganglia in the base of the skull and middle ear."
      },
      "child_count": 4,
      "reference_id": "MONDO:0021064"
    },
    {
      "id": 21266,
      "label": "tympanic paraganglioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7791,
        16045,
        18718,
        22991
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008658",
          "GTR:AN0102047",
          "GTR:AN0102048",
          "MEDGEN:105375",
          "MESH:D043604",
          "NCIT:C8428",
          "SCTID:253031000",
          "UMLS:C0474820"
        ],
        "synonyms": [
          "tympanic paraganglioma",
          "Glomus Tympanicum Tumor",
          "Glomus Tympanicum Tumors",
          "Glomus Tympanicum Tumour",
          "Glomus Tympanicum Tumours",
          "Glomus tympanicum paraganglioma",
          "Glomus tympanicum tumor",
          "Glomus tympanicum tumour",
          "Tumor, Glomus Tympanicum",
          "Tumors, Glomus Tympanicum",
          "Tympanic Paraganglioma",
          "Tympanic paraganglioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A benign or malignant middle ear paraganglioma arising from paraganglia around the tympanum. Signs and symptoms include a mass behind the tympanum, tinnitus, and conductive hearing loss."
      },
      "child_count": 0,
      "reference_id": "MONDO:0023682"
    },
    {
      "id": 23431,
      "label": "vagus nerve paraganglioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3805,
        7791,
        20295
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008620",
          "MEDGEN:141635",
          "NCIT:C8427",
          "SCTID:253030004",
          "UMLS:C0474819"
        ],
        "synonyms": [
          "paraganglioma of the vagal body",
          "paraganglioma of the vagus nerve",
          "paraganglioma of vagal body",
          "paraganglioma of vagus nerve",
          "vagal body paraganglioma",
          "vagal paraganglioma",
          "vagus nerve paraganglioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant extra-adrenal parasympathetic paraganglioma arising from paraganglia in the vagus nerve. Patients may present with a slow growing, painless mass in the neck, hoarseness, vocal cord paralysis, and dysphagia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044768"
    }
  ],
  "roots": [
    {
      "id": 2912,
      "label": "paraganglioma"
    },
    {
      "id": 7231,
      "label": "head and neck neoplasm"
    }
  ]
}