{
  "id": 7797,
  "label": "histiocytic and dendritic cell neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006247",
  "properties": {
    "xrefs": [
      "DOID:5621",
      "EFO:1000297",
      "GARD:0019441",
      "MEDGEN:714988",
      "NCIT:C9294",
      "Orphanet:98287",
      "UMLS:C1292762"
    ],
    "synonyms": [
      "histiocytic and Dendritic cell neoplasms",
      "histiocytic and Dendritic cell tumors",
      "histiocytic and Dendritic cell tumours",
      "histiocytic and dendritic cell neoplasm",
      "histiocytic and dendritic cell",
      "histiocytic and dendritic cell cancer",
      "histiocytic and dendritic cell tumor",
      "histiocytic and dendritic cell tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Rare tumors that affect the hematopoietic and lymphoid tissues. The cells of origin are the histiocytes and accessory cells. They can occur at any age and show no significant variations in geographical distribution. This category includes the histiocytic sarcoma, Langerhans cell histiocytosis, Langerhans cell sarcoma, interdigitading dendritic cell sarcoma/tumor, follicular dendritic cell sarcoma/tumor, and dendritic cell sarcoma, not otherwise specified. (WHO, 2001)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 16514,
      "label": "lymphoid hemopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4440
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020131",
          "MEDGEN:1842533",
          "Orphanet:171898",
          "UMLS:C5680515"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 4,
      "reference_id": "MONDO:0015757"
    },
    {
      "id": 23467,
      "label": "hematopoietic and lymphoid cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4440
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025916",
          "MEDGEN:91264",
          "NCIT:C27134",
          "UMLS:C0376544"
        ],
        "synonyms": [
          "HEMOLYMPHORETICULAR tumor, malignant",
          "haematological neoplasm",
          "haematological tumour",
          "haematopoietic and lymphoid neoplasms",
          "haematopoietic cancer",
          "haematopoietic cell tumour",
          "haematopoietic malignancy, NOS",
          "haematopoietic neoplasm",
          "haematopoietic neoplasms including lymphomas",
          "haematopoietic tumour",
          "hematologic cancer",
          "hematologic malignancy",
          "hematologic neoplasm",
          "hematological neoplasm",
          "hematological tumor",
          "hematopoietic and lymphoid cell neoplasm",
          "hematopoietic and lymphoid neoplasms",
          "hematopoietic cancer",
          "hematopoietic cell tumor",
          "hematopoietic malignancy, NOS",
          "hematopoietic neoplasm",
          "hematopoietic neoplasms including lymphomas",
          "hematopoietic tumor",
          "hematopoietic, Including myeloma",
          "malignant haematopoietic neoplasm",
          "malignant hematologic neoplasm",
          "malignant hematopoietic neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm arising from hematopoietic cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic system). Hematopoietic cell neoplasms can also involve other anatomic sites (e.g. central nervous system, gastrointestinal tract), either by metastasis, direct tumor infiltration, or neoplastic transformation of extranodal lymphoid tissues. The commonest forms are the various types of leukemia, Hodgkin and non-Hodgkin lymphomas, myeloproliferative neoplasms, and myelodysplastic syndromes."
      },
      "child_count": 8,
      "reference_id": "MONDO:0044881"
    }
  ],
  "children": [
    {
      "id": 16352,
      "label": "indeterminate dendritic cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7797,
        16345
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020022",
          "MEDGEN:415159",
          "NCIT:C81767",
          "ONCOTREE:IDCT",
          "Orphanet:158019",
          "SCTID:721313009",
          "UMLS:C2825741"
        ],
        "synonyms": [
          "indeterminate Dendritic cell tumor",
          "indeterminate Dendritic cell tumour",
          "indeterminate cell histiocytosis",
          "indeterminate dendritic cell tumor",
          "IDCT"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A very rare dendritic cell tumor composed of spindle to ovoid cells with a phenotype that is similar to the Langerhans cells. Patients usually present with cutaneous papules, nodules, and plaques. Systemic symptoms are usually absent. The clinical course is variable."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015538"
    },
    {
      "id": 19303,
      "label": "histiocytic sarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7797
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080915",
          "GARD:0019080",
          "ICD10CM:C96.A",
          "ICD9:171.9",
          "ICDO:9755/3",
          "MEDGEN:137793",
          "MESH:D054747",
          "NCIT:C27349",
          "ONCOTREE:HS",
          "Orphanet:86896",
          "SCTID:109988003",
          "UMLS:C0334663",
          "icd11.foundation:1925254893",
          "icd11.foundation:911785965"
        ],
        "synonyms": [
          "histiocytic sarcoma",
          "sarcoma, histiocytic, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An aggressive malignant neoplasm with a poor response to therapy, usually presenting as stage III/IV disease. It is characterized by the presence of neoplastic cells with morphologic and immunophenotypic characteristics similar to those seen in mature histiocytes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019479"
    },
    {
      "id": 19729,
      "label": "dendritic cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7797
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008317",
          "MEDGEN:1842732",
          "Orphanet:98289",
          "SCTID:737223000",
          "UMLS:C5681852"
        ],
        "synonyms": [
          "dendritic cell sarcoma, NOS",
          "dendritic cell sarcoma, Not otherwise specified",
          "dendritic cell tumor, NOS",
          "dendritic cell tumor, not otherwise specified",
          "dendritic cell neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A dendritic cell tumor develops from the cells of the immune system. This condition typically begins in the lymph system and may spread to nearby organs or distant parts of the body (metastasize). The symptoms and severity of the condition depend on the subtype and location of the tumor."
      },
      "child_count": 3,
      "reference_id": "MONDO:0020082"
    }
  ],
  "roots": [
    {
      "id": 16514,
      "label": "lymphoid hemopathy"
    },
    {
      "id": 23467,
      "label": "hematopoietic and lymphoid cell neoplasm"
    }
  ]
}