{ "id": 7803, "label": "invasive breast carcinoma", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0006256", "properties": { "xrefs": [ "EFO:1000307", "MEDGEN:163435", "NCIT:C9245", "ONCOTREE:BRCA", "SCTID:713609000", "UMLS:C0853879", "icd11.foundation:2090549892" ], "synonyms": [ "infiltrating breast cancer", "infiltrating breast carcinoma", "infiltrating carcinoma of breast", "infiltrating carcinoma of the breast", "invasive breast cancer", "invasive breast carcinoma", "invasive carcinoma of breast", "invasive carcinoma of the breast", "invasive mammary carcinoma", "BRCA" ], "categories": [ { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "A carcinoma that infiltrates the breast parenchyma. The vast majority are adenocarcinomas arising from the terminal ductal lobular unit (TDLU). Often, the invasive adenocarcinoma co-exists with ductal or lobular carcinoma in situ. It is the most common carcinoma affecting women." }, "isLeaf": false, "isRoot": false, "child_count": 11, "parents": [ { "id": 6730, "label": "breast carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6734, 8659 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3459", "EFO:0000305", "HP:0003002", "MEDGEN:146260", "NCIT:C4872", "SCTID:254838004", "UMLS:C0678222" ], "synonyms": [ "breast cancer", "breast cancer, NOS", "cancer of breast", "cancer of the breast", "cancer, breast", "breast carcinoma", "carcinoma of breast", "carcinoma of the breast", "mammary carcinoma" ], "categories": [ { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "A carcinoma that arises from epithelial cells of the breast" }, "child_count": 26, "reference_id": "MONDO:0004989" }, { "id": 23004, "label": "invasive carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6734 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:233579", "NCIT:C9480", "UMLS:C1334274" ], "synonyms": [ "invasive carcinoma" ], "definition": "A carcinoma that is not confined to the epithelium, and has spread to the surrounding stroma." }, "child_count": 4, "reference_id": "MONDO:0040677" } ], "children": [ { "id": 4719, "label": "signet ring cell breast carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6729, 6819, 7803 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3503", "MEDGEN:236816", "NCIT:C5175", "ONCOTREE:BRSRCC", "UMLS:C1335964" ], "synonyms": [ "SRC breast carcinoma", "SRC carcinoma of breast", "SRC carcinoma of the breast", "breast signet ring cell carcinoma", "mammary signet Ring cell carcinoma", "primary SRC breast carcinoma", "primary SRC carcinoma of breast", "primary SRC carcinoma of the breast", "primary mammary signet Ring cell carcinoma", "primary signet Ring cell breast carcinoma", "primary signet Ring cell carcinoma of breast", "primary signet Ring cell carcinoma of the breast", "signet Ring cell breast carcinoma", "signet Ring cell carcinoma of breast", "signet Ring cell carcinoma of the breast", "breast carcinoma with signet ring", "breast signet ring cell adenocarcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "An invasive breast adenocarcinoma characterized by the presence of malignant epithelial cells with signet ring appearance." }, "child_count": 0, "reference_id": "MONDO:0002671" }, { "id": 5073, "label": "mucoepidermoid breast carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 5029, 6729, 7803 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4679", "GARD:0023361", "MEDGEN:233721", "NCIT:C5166", "UMLS:C1334813" ], "synonyms": [ "breast mucoepidermoid carcinoma", "mucoepidermoid breast carcinoma", "mucoepidermoid carcinoma of breast", "mucoepidermoid carcinoma of the breast" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "A carcinoma of the breast characterized by pools of mucin and islands of malignant squamous cells. Mucoepidermoid carcinomas of the breast are extremely rare." }, "child_count": 0, "reference_id": "MONDO:0003087" }, { "id": 5145, "label": "adenoid cystic breast carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6713, 6729, 7803 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4877", "EFO:1000071", "GARD:0023402", "MEDGEN:231031", "NCIT:C5130", "ONCOTREE:ACBC", "UMLS:C1332167" ], "synonyms": [ "adenocystic breast carcinoma", "adenocystic carcinoma of breast", "adenocystic carcinoma of the breast", "adenoid cystic breast carcinoma", "adenoid cystic carcinoma of breast", "adenoid cystic carcinoma of the breast", "breast adenoid cystic carcinoma", "mammary adenocystic carcinoma", "mammary adenoid cystic carcinoma", "adenoid cystic breast cancer" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "An adenoid cystic carcinoma primarily involving the breast. Three morphologic patterns are seen: cribriform, trabecular, and solid. The prognosis is excellent." }, "child_count": 0, "reference_id": "MONDO:0003185" }, { "id": 5524, "label": "sebaceous breast carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6729, 7803, 8388 ], "type_id": 0, "properties": { "xrefs": [ "DOID:5760", "MEDGEN:276789", "NCIT:C40369", "UMLS:C1519207" ], "synonyms": [ "breast sebaceous adenocarcinoma", "sebaceous adenocarcinoma of breast" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "A very rare breast adenocarcinoma with sebaceous differentiation." }, "child_count": 0, "reference_id": "MONDO:0003635" }, { "id": 5794, "label": "oncocytic breast carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6729, 7803 ], "type_id": 0, "properties": { "xrefs": [ "DOID:6585", "MEDGEN:309476", "NCIT:C40366", "UMLS:C1518574" ], "synonyms": [ "oncocytic breast carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "A rare breast adenocarcinoma characterized by the presence of neoplastic oncocytic cells. The oncocytic cells comprise more than 70 percent of the malignant cellular population." }, "child_count": 0, "reference_id": "MONDO:0003935" }, { "id": 5817, "label": "breast large cell neuroendocrine carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 4564, 6787, 7803 ], "type_id": 0, "properties": { "xrefs": [ "DOID:6657", "GARD:0023753", "MEDGEN:307310", "NCIT:C40356", "UMLS:C1511316" ], "synonyms": [ "breast large cell neuroendocrine carcinoma", "large cell neuroendocrine carcinoma of breast" ], "categories": [ { "ref": "MONDO:0002657", "name": "breast disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A poorly differentiated neuroendocrine carcinoma that arises from the breast. It is characterized by the presence of large neuroendocrine cells and high mitotic activity." }, "child_count": 0, "reference_id": "MONDO:0003959" }, { "id": 5843, "label": "malignant breast myoepithelioma", "isLeaf": true, "isRoot": false, "parents": [ 4563, 5127, 7803 ], "type_id": 0, "properties": { "xrefs": [ "DOID:6776", "GARD:0027662", "MEDGEN:309375", "NCIT:C40395", "UMLS:C1518167" ], "synonyms": [ "breast malignant myoepithelioma", "breast myoepithelial carcinoma", "malignant breast myoepithelioma" ], "categories": [ { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "An invasive malignant tumor that arises from the breast. It is characterized by the presence of spindle-shaped myoepithelial cells. Mitoses are present. Rarely, local recurrences and distant metastases have been reported." }, "child_count": 0, "reference_id": "MONDO:0003990" }, { "id": 6698, "label": "invasive ductal breast carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 7234, 7803 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3008", "EFO:0000186", "ICD9:174.8", "ICDO:8500/3", "ICDO:8521/3", "MEDGEN:730612", "NCIT:C4194", "ONCOTREE:IDC", "SCTID:408643008", "UMLS:C1412014" ], "synonyms": [ "infiltrating ductal adenocarcinoma", "infiltrating ductal breast carcinoma", "infiltrating ductal carcinoma", "infiltrating ductal carcinoma of breast", "infiltrating ductal carcinoma of the breast", "invasive ductal adenocarcinoma", "invasive ductal breast carcinoma", "invasive ductal carcinoma", "invasive ductal carcinoma of breast", "invasive ductal carcinoma of the breast", "invasive ductal carcinoma, NST", "invasive ductal carcinoma, No specific type", "breast invasive ductal carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "The most common type of invasive breast carcinoma, accounting for approximately 70% of breast carcinomas. The gross appearance is usually typical with an irregular stellate outline. Microscopically, randomly arranged epithelial elements are seen. When large sheets of malignant cells are present, necrosis may be seen. With adequate tissue sampling, in situ carcinoma can be demonstrated in association with the infiltrating carcinoma. The in situ component is nearly always ductal but occasionally may be lobular or both." }, "child_count": 20, "reference_id": "MONDO:0004953" }, { "id": 6782, "label": "invasive lobular breast carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 2991, 7803 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3457", "EFO:0000553", "MEDGEN:75994", "NCIT:C7950", "ONCOTREE:ILC", "UMLS:C0279565" ], "synonyms": [ "lobular carcinoma", "lobular carcinoma (morphologic abnormality)", "lobular carcinoma NOS (morphologic abnormality)", "lobular carcinoma of the breast", "classic invasive lobular carcinoma", "infiltrating lobular adenocarcinoma", "infiltrating lobular breast carcinoma", "infiltrating lobular carcinoma of breast", "infiltrating lobular carcinoma of the breast", "invasive lobular adenocarcinoma", "invasive lobular breast carcinoma", "invasive lobular carcinoma", "invasive lobular carcinoma of breast", "invasive lobular carcinoma of the breast", "invasive lobular carcinoma, classic type", "breast invasive lobular carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "An infiltrating lobular adenocarcinoma of the breast. The malignant cells lack cohesion and are arranged individually or in a linear manner (Indian files), or as narrow trabeculae within the stroma. The malignant cells are usually smaller than those of ductal carcinoma, are less pleomorphic, and have fewer mitotic figures." }, "child_count": 0, "reference_id": "MONDO:0005051" }, { "id": 7629, "label": "metaplastic breast carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 7803 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4680", "EFO:1000040", "GARD:0010804", "MEDGEN:277360", "NCIT:C5164", "ONCOTREE:MBC", "Orphanet:213531", "SCTID:763479005", "UMLS:C1334708", "icd11.foundation:313445809" ], "synonyms": [ "metaplastic breast carcinoma", "metaplastic carcinoma of breast", "metaplastic carcinoma of the breast", "breast metaplastic carcinoma", "metaplastic breast cancer" ], "categories": [ { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "A group of invasive breast carcinomas characterized by the presence of an adenocarcinomatous component which is admixed with a dominant component that is composed of squamous cells, spindle cells, or mesenchymal cells." }, "child_count": 2, "reference_id": "MONDO:0006043" }, { "id": 8252, "label": "inflammatory breast carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6729, 7803 ], "type_id": 0, "properties": { "xrefs": [ "DOID:6263", "EFO:1000984", "GARD:0006784", "ICDO:8530/3", "MEDGEN:75841", "MESH:D058922", "MedDRA:10006205", "NCIT:C4001", "ONCOTREE:IBC", "Orphanet:694963", "SCTID:254840009", "UMLS:C0278601" ], "synonyms": [ "inflammatory breast cancer", "inflammatory breast carcinoma", "inflammatory carcinoma of breast", "inflammatory carcinoma of the breast", "mastitis Carcinomatosa", "mastitis carcinomatosa", "IBC", "breast cancer, inflammatory" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "An advanced, invasive breast adenocarcinoma characterized by the presence of distinct changes in the overlying skin. These changes include diffuse erythema, edema, peau d'orange (skin of an orange) appearance, tenderness, induration, warmth, enlargement, and in some cases a palpable mass. The skin changes are the consequence of lymphatic obstruction from the underlying invasive breast adenocarcinoma. Microscopically, the dermal lymphatics show prominent infiltration by malignant cells. The invasive breast adenocarcinoma is usually of ductal, NOS type. There is not significant inflammatory cell infiltrate present, despite the name of this carcinoma." }, "child_count": 0, "reference_id": "MONDO:0006804" } ], "roots": [ { "id": 6730, "label": "breast carcinoma" }, { "id": 23004, "label": "invasive carcinoma" } ] }