{
  "id": 7810,
  "label": "Leydig cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006266",
  "properties": {
    "xrefs": [
      "DOID:2696",
      "EFO:1000321",
      "ICDO:8650/1",
      "MEDGEN:9747",
      "MESH:D007984",
      "NCIT:C3188",
      "UMLS:C0023601"
    ],
    "synonyms": [
      "Leydig cell neoplasm",
      "Leydig cell tumor",
      "interstitial cell neoplasm",
      "interstitial cell tumor",
      "interstitial cell tumour",
      "Leydig cell tumor, undetermined"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A sex cord-stromal tumor occurring in the testis and rarely in the ovary. It is predominantly or completely composed of Leydig cells which may contain crystals of Reinke. In males it usually presents as a painless testicular enlargement and it may be associated with gynecomastia and decreased libido. The majority of the cases have a benign clinical course. Approximately 10% of the cases have a malignant clinical course and metastasize. In females it may be associated with androgenic manifestations and it follows a benign clinical course."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 7639,
      "label": "sex cord-stromal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:192",
          "EFO:1000052",
          "ICDO:8590/1",
          "MEDGEN:104926",
          "NANDO:2200072",
          "NCIT:C3794",
          "UMLS:C0206724"
        ],
        "synonyms": [
          "Sex cord stromal tumor",
          "Sex cord-stromal neoplasm",
          "Sex cord-stromal tumor",
          "Sex cord-stromal tumor, no ICD-O subtype",
          "Sex cord-stromal tumor, no ICD-O subtype (morphologic abnormality)",
          "Sex cord-stromal tumour",
          "neoplasm of sex cord",
          "sex cord neoplasm",
          "sex cord tumor",
          "sex cord tumour",
          "sex cord-stromal tumor",
          "specialised gonadal neoplasm",
          "specialised gonadal neoplasm (morphologic abnormality)",
          "specialised gonadal neoplasm NOS (morphologic abnormality)",
          "specialised gonadal tumour",
          "specialised gonadal tumour (qualifier value)",
          "specialized gonadal neoplasm (morphologic abnormality)",
          "specialized gonadal neoplasm NOS (morphologic abnormality)",
          "specialized gonadal tumor (qualifier value)",
          "tumor of sex cord",
          "tumour of sex cord",
          "malignant testicular sex cord-stromal tumor",
          "malignant testicular sex cord-stromal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A neoplasm involving a sex cord."
      },
      "child_count": 9,
      "reference_id": "MONDO:0006055"
    }
  ],
  "children": [
    {
      "id": 2876,
      "label": "malignant Leydig cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        7810
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050616",
          "ICDO:8650/3",
          "MEDGEN:83143",
          "NCIT:C4213",
          "UMLS:C0334410"
        ],
        "synonyms": [
          "Leydig cell cancer",
          "Leydig cell tumor, malignant",
          "cancer of Leydig cell",
          "malignant Leydig cell neoplasm",
          "malignant interstitial cell neoplasm",
          "malignant neoplasm of Leydig cell",
          "malignant interstitial cell tumor",
          "malignant interstitial cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A Leydig cell tumor characterized by large tumor size, the presence of cytologic atypia, increased mitotic activity, necrosis, and vascular invasion. Approximately 10% of the testicular Leydig cell tumors show malignant characteristics and metastasize. Leydig cell tumors of the ovary follow a benign clinical course."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000377"
    },
    {
      "id": 5101,
      "label": "testicular Leydig cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5102,
        7810
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4756",
          "GARD:0023375",
          "MEDGEN:163584",
          "NCIT:C6356",
          "SCTID:67871000119105",
          "UMLS:C0863027"
        ],
        "synonyms": [
          "Leydig cell neoplasm of testis",
          "Leydig cell neoplasm of the testis",
          "Leydig cell tumor of testis",
          "Leydig cell tumour of testis",
          "testicular Leydig cell neoplasm",
          "testicular Leydig cell tumor",
          "testis Leydig cell tumor",
          "testis Leydig cell tumour",
          "Leydig cell tumor of the testis",
          "Leydig cell tumour of the testis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A sex cord-stromal tumor that arises from the testis and is characterized by the presence of cells that resemble the successive stages of development of Leydig cells. It usually presents as a painless testicular mass. Gynecomastia is present in approximately thirty percent of the cases. Libido may be decreased. In children, precocious puberty may be present. A minority of cases exhibit malignant characteristics."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003124"
    },
    {
      "id": 22953,
      "label": "benign Leydig cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7810,
        21634
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:8650/0",
          "MEDGEN:83142",
          "NCIT:C4212",
          "UMLS:C0334409"
        ],
        "synonyms": [
          "Leydig cell tumor, benign",
          "adenoma, interstitial",
          "benign Leydig cell neoplasm",
          "benign Leydig cell tumor",
          "benign interstitial cell neoplasm",
          "benign interstitial cell tumor",
          "benign interstitial cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A Leydig cell tumor which does not recur or metastasize. Morphologically, there is no evidence of cellular atypia, increased mitotic activity, necrosis, or vascular invasion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0036990"
    }
  ],
  "roots": [
    {
      "id": 7639,
      "label": "sex cord-stromal tumor"
    }
  ]
}