{
  "id": 7812,
  "label": "liver diffuse large B-cell lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006268",
  "properties": {
    "xrefs": [
      "EFO:1000323",
      "GARD:0024354",
      "MEDGEN:473542",
      "NCIT:C96843",
      "UMLS:C2184126"
    ],
    "synonyms": [
      "diffuse large B-cell lymphoma of liver",
      "hepatic diffuse large B-cell lymphoma",
      "liver diffuse large B-cell lymphoma",
      "primary hepatic diffuse large B-cell lymphoma",
      "primary liver diffuse large B-cell lymphoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A rare diffuse large B-cell lymphoma that arises from the liver and the bulk of the tumor is located in the liver."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3028,
      "label": "immune system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060083"
        ],
        "synonyms": [
          "cancer of immune system",
          "immune system cancer",
          "malignant immune system neoplasm",
          "malignant neoplasm of immune system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the immune system"
      },
      "child_count": 50,
      "reference_id": "MONDO:0000621"
    },
    {
      "id": 6475,
      "label": "liver lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4735,
        6479
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:901",
          "GARD:0024089",
          "MEDGEN:207276",
          "NCIT:C4949",
          "UMLS:C1112746"
        ],
        "synonyms": [
          "hepatic lymphoma",
          "liver lymphoma",
          "lymphoma of liver",
          "lymphoma of the liver",
          "primary hepatic lymphoma",
          "primary liver lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare lymphoma that arises from the liver and the bulk of the tumor is located in the liver. The most frequent types of lymphoma that arise from the liver are diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004695"
    },
    {
      "id": 8660,
      "label": "hepatocellular carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        18551
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:684",
          "DOID:686",
          "EFO:0000182",
          "GARD:0016773",
          "ICD10CM:C22.0",
          "ICDO:8170/3",
          "MEDGEN:389187",
          "MESH:D006528",
          "MedDRA:10049010",
          "NANDO:2200047",
          "NCIT:C3099",
          "NORD:1907",
          "OMIM:114550",
          "ONCOTREE:HCC",
          "Orphanet:88673",
          "UMLS:C2239176",
          "icd11.foundation:1294035808"
        ],
        "synonyms": [
          "HCC",
          "cancer, hepatocellular",
          "carcinoma of liver",
          "carcinoma of liver cells",
          "carcinoma of the liver cells",
          "carcinoma, hepatocellular, malignant",
          "hepatoblastoma, somatic",
          "hepatocellular adenocarcinoma",
          "hepatocellular cancer",
          "hepatocellular cancer, somatic",
          "hepatocellular carcinoma",
          "hepatocellular carcinoma, childhood type, somatic",
          "hepatocellular carcinoma, somatic",
          "hepatoma",
          "liver carcinoma",
          "liver cell cancer (hepatocellular carcinoma)",
          "liver cell carcinoma",
          "primary carcinoma of liver cells",
          "primary carcinoma of the liver cells",
          "adult hepatoma",
          "adult primary hepatocellular carcinoma",
          "hepatoblastoma",
          "hepatoblastoma caused by somatic mutation",
          "liver and intrahepatic bile duct carcinoma",
          "liver cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation."
      },
      "child_count": 16,
      "reference_id": "MONDO:0007256"
    },
    {
      "id": 18833,
      "label": "diffuse large B-cell lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6694,
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050745",
          "EFO:0000403",
          "GARD:0003178",
          "ICD10CM:C83.3",
          "ICD9:200.7",
          "ICDO:9680/3",
          "MEDGEN:86954",
          "MESH:D016403",
          "MedDRA:10012818",
          "NCIT:C8851",
          "Orphanet:544",
          "UMLS:C0079744",
          "icd11.foundation:1946973604"
        ],
        "synonyms": [
          "DLBCL",
          "diffuse large B-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common."
      },
      "child_count": 60,
      "reference_id": "MONDO:0018905"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3028,
      "label": "immune system cancer"
    },
    {
      "id": 6475,
      "label": "liver lymphoma"
    },
    {
      "id": 8660,
      "label": "hepatocellular carcinoma"
    },
    {
      "id": 18833,
      "label": "diffuse large B-cell lymphoma"
    }
  ]
}