{
  "id": 7813,
  "label": "lobular breast carcinoma in situ",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006270",
  "properties": {
    "xrefs": [
      "EFO:1000326",
      "ICD10CM:D05.0",
      "ICDO:8520/2",
      "MEDGEN:79007",
      "NCIT:C4018",
      "ONCOTREE:LCIS",
      "SCTID:109888004",
      "UMLS:C0279563"
    ],
    "synonyms": [
      "LCIS",
      "lobular Ca in situ of breast",
      "lobular Ca in situ of the breast",
      "lobular breast carcinoma in situ",
      "lobular carcinoma in situ",
      "lobular carcinoma in situ (LCIS)",
      "lobular carcinoma in situ of breast",
      "lobular carcinoma in situ of the breast",
      "lobular carcinoma in situ of the breast (LCIS)",
      "non-infiltrating lobular breast carcinoma",
      "non-infiltrating lobular carcinoma",
      "non-infiltrating lobular carcinoma of breast",
      "non-infiltrating lobular carcinoma of the breast",
      "non-invasive lobular breast carcinoma",
      "non-invasive lobular carcinoma of breast",
      "non-invasive lobular carcinoma of the breast",
      "breast lobular carcinoma in situ"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "A non-invasive adenocarcinoma of the breast characterized by a proliferation of monomorphic cells completely filling the lumina. The overall lobular architecture is preserved. It is frequently multifocal (90% in some series) and bilateral. It seldom becomes invasive; however there is an increased risk of infiltrating ductal adenocarcinoma."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4565,
      "label": "lobular neoplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6442
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3010",
          "MEDGEN:167824",
          "NCIT:C27939",
          "UMLS:C0861352"
        ],
        "synonyms": [
          "LIN",
          "LN",
          "lobular intraepithelial neoplasia",
          "lobular neoplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A spectrum of non-invasive neoplastic lesions that arise from the terminal ductal lobular units of the breast. There is atypical small epithelial cell proliferation. Pagetoid involvement of the terminal ducts may or may not be present. In the minority of cases, there is a risk for subsequent development of invasive ductal or invasive lobular carcinoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002486"
    },
    {
      "id": 5172,
      "label": "adenocarcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6433,
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4943",
          "ICDO:8140/2",
          "MEDGEN:87203",
          "MESH:D065311",
          "NCIT:C4123",
          "ONCOTREE:AIS",
          "UMLS:C0334276"
        ],
        "synonyms": [
          "adenocarcinoma in situ",
          "AIS"
        ],
        "definition": "A lesion in which the normally situated glands are partially or completely replaced by atypical cells with malignant characteristics."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003218"
    },
    {
      "id": 6729,
      "label": "breast adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3053,
        6712,
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3458",
          "EFO:0000304",
          "MEDGEN:167809",
          "NCIT:C5214",
          "UMLS:C0858252"
        ],
        "synonyms": [
          "adenocarcinoma of breast",
          "adenocarcinoma of the breast",
          "breast adenocarcinoma",
          "mammary adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the breast"
      },
      "child_count": 39,
      "reference_id": "MONDO:0004988"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4565,
      "label": "lobular neoplasia"
    },
    {
      "id": 5172,
      "label": "adenocarcinoma in situ"
    },
    {
      "id": 6729,
      "label": "breast adenocarcinoma"
    }
  ]
}