{
  "id": 7822,
  "label": "lung sarcomatoid carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006279",
  "properties": {
    "xrefs": [
      "DOID:0080777",
      "EFO:1000336",
      "ICD9:162.9",
      "MEDGEN:353871",
      "NCIT:C45540",
      "ONCOTREE:SARCL",
      "SCTID:707460002",
      "UMLS:C1708781"
    ],
    "synonyms": [
      "lung sarcomatoid carcinoma",
      "sarcomatoid carcinoma of the lung"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A rare, aggressive, poorly differentiated, non-small cell lung carcinoma characterized by the presence of a sarcomatoid component often associated with giant cell differentiation. There is a male to female ratio of 4:1. Clinical symptoms include cough, hemoptysis, chest pain, progressive dyspnea and fever secondary to recurrent pneumonia. Cigarette smoking is a major risk factor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 5040,
      "label": "lung large cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6943,
        6944
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4556",
          "EFO:0003050",
          "ICD9:162.9",
          "MEDGEN:91060",
          "NCIT:C4450",
          "ONCOTREE:LCLC",
          "SCTID:254629004",
          "UMLS:C0345958"
        ],
        "synonyms": [
          "anaplastic lung carcinoma",
          "large cell carcinoma of lung",
          "large cell carcinoma of the lung",
          "large cell lung cancer",
          "large cell lung carcinoma",
          "large cell undifferentiated lung carcinoma",
          "lung large cell carcinoma",
          "LCLC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A poorly differentiated non-small cell lung carcinoma composed of large polygonal cells without evidence of glandular or squamous differentiation. There is a male predilection."
      },
      "child_count": 14,
      "reference_id": "MONDO:0003050"
    },
    {
      "id": 7925,
      "label": "sarcomatoid carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        20048,
        20076
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4015",
          "EFO:1000520",
          "ICDO:8032/3",
          "ICDO:8033/3",
          "MEDGEN:60009",
          "NCIT:C27004",
          "UMLS:C0205697"
        ],
        "synonyms": [
          "carcinoma, spindle cell, malignant",
          "pseudosarcomatous carcinoma",
          "sarcomatoid carcinoma",
          "spindle cell carcinoma",
          "spindle cell carcinoma (morphologic abnormality)"
        ],
        "definition": "A malignant epithelial neoplasm characterized by the presence of spindle cells and anaplastic morphologic features. Giant cells and a sarcomatous component may also be present."
      },
      "child_count": 24,
      "reference_id": "MONDO:0006406"
    }
  ],
  "children": [
    {
      "id": 7531,
      "label": "pulmonary blastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7213,
        7822
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4765",
          "EFO:0007458",
          "GARD:0018864",
          "ICD9:162.9",
          "ICDO:8972/3",
          "MEDGEN:61645",
          "MESH:D018202",
          "NCIT:C3732",
          "Orphanet:64741",
          "SCTID:189815007",
          "UMLS:C0206629"
        ],
        "synonyms": [
          "Pneumoblastoma",
          "blastoma of lung",
          "blastoma of the lung",
          "lung blastoma",
          "pulmonary blastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A malignant neoplasm of the lung composed of tubular structures and immature mesenchymal elements, which may differentiate towards skeletal and smooth muscle, cartilage or a combination of muscle and cartilage. This is a nodular tumor found in the periphery of the lung. It can occur at any age. The prognosis is related to the stage of the disease at the time of resection. Pulmonary blastoma is divided into two subtypes: epithelial predominant and biphasic."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005933"
    },
    {
      "id": 7818,
      "label": "lung giant cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7822
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5583",
          "EFO:1000332",
          "ICD9:162.9",
          "MEDGEN:83392",
          "MESH:D018286",
          "NCIT:C4452",
          "ONCOTREE:GCLC",
          "SCTID:254631008",
          "UMLS:C0345960"
        ],
        "synonyms": [
          "giant cell carcinoma",
          "giant cell carcinoma of lung",
          "giant cell carcinoma of the lung",
          "lung giant cell carcinoma",
          "GCLC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A morphologic variant of lung sarcomatoid carcinoma characterized by the presence of mononuclear and multinucleated pleomorphic neoplastic giant cells that lack cohesion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006275"
    },
    {
      "id": 25207,
      "label": "lung pleomorphic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5472,
        7822
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080899",
          "MEDGEN:314017",
          "NCIT:C45542",
          "UMLS:C1711397"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A pleomorphic carcinoma that is characterized by the presence of malignant glandular or squamous cells associated with malignant giant and spindle cells and that is located in the lung."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850345"
    }
  ],
  "roots": [
    {
      "id": 5040,
      "label": "lung large cell carcinoma"
    },
    {
      "id": 7925,
      "label": "sarcomatoid carcinoma"
    }
  ]
}