{
  "id": 7827,
  "label": "major salivary gland carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006284",
  "properties": {
    "xrefs": [
      "EFO:1000344",
      "GARD:0027745",
      "MEDGEN:235287",
      "NCIT:C5907",
      "UMLS:C1334549"
    ],
    "synonyms": [
      "major salivary gland cancer",
      "carcinoma of Major salivary gland",
      "carcinoma of major salivary gland",
      "carcinoma of the major salivary gland",
      "major salivary gland carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0006858",
        "name": "mouth disorder"
      }
    ],
    "definition": "A carcinoma that arises from the parotid gland, submandibular gland, or sublingual gland."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 2972,
      "label": "salivary gland carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6453,
        23483
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050904",
          "GARD:0027535",
          "MEDGEN:215302",
          "NANDO:2200076",
          "NCIT:C9272",
          "ONCOTREE:SACA",
          "UMLS:C0948750"
        ],
        "synonyms": [
          "salivary gland cancer",
          "carcinoma of saliva-secreting gland",
          "carcinoma of salivary gland",
          "carcinoma of the salivary gland",
          "saliva-secreting gland carcinoma",
          "salivary gland carcinoma",
          "salivary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A carcinoma that arises from the major or minor salivary glands. Representative examples include carcinoma ex pleomorphic adenoma, adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma."
      },
      "child_count": 26,
      "reference_id": "MONDO:0000521"
    },
    {
      "id": 23418,
      "label": "major salivary gland cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6453,
        20529
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027972",
          "MEDGEN:96919",
          "NCIT:C4762",
          "SCTID:363378008",
          "UMLS:C0496763"
        ],
        "synonyms": [
          "cancer of major salivary gland",
          "malignant major salivary gland neoplasm",
          "malignant major salivary gland tumor",
          "malignant major salivary gland tumour",
          "malignant neoplasm of major salivary gland",
          "malignant neoplasm of the major salivary gland",
          "malignant tumor of major salivary gland",
          "malignant tumor of the major salivary gland",
          "malignant tumour of major salivary gland",
          "malignant tumour of the major salivary gland",
          "malignant neoplasm of major salivary glands"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm affecting the major salivary glands. Representative examples include carcinoma, lymphoma, and sarcoma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0044743"
    }
  ],
  "children": [
    {
      "id": 6500,
      "label": "submandibular gland cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7827,
        20453
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9173",
          "GARD:0027705",
          "ICD10CM:C08.0",
          "ICD9:142.1",
          "MEDGEN:57782",
          "NCIT:C3526",
          "NCIT:C8396",
          "SCTID:363380002",
          "UMLS:C0153360"
        ],
        "synonyms": [
          "cancer of submandibular gland",
          "malignant neoplasm of submandibular gland",
          "malignant neoplasm of submaxillary gland",
          "malignant submandibular gland neoplasm",
          "malignant tumor of submandibular gland",
          "malignant tumor of the submandibular gland",
          "malignant tumour of submandibular gland",
          "malignant tumour of the submandibular gland",
          "submandibular gland cancer",
          "carcinoma of submandibular gland",
          "carcinoma of the submandibular gland",
          "submandibular gland carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the submandibular gland."
      },
      "child_count": 6,
      "reference_id": "MONDO:0004724"
    },
    {
      "id": 7828,
      "label": "major salivary gland carcinoma ex pleomorphic adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7827,
        7922
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000345",
          "GARD:0027746",
          "MEDGEN:233655",
          "NCIT:C5975",
          "UMLS:C1334550"
        ],
        "synonyms": [
          "carcinoma ex pleomorphic adenoma of Major salivary gland",
          "carcinoma ex pleomorphic adenoma of the Major salivary gland",
          "major salivary gland carcinoma ex pleomorphic adenoma",
          "major salivary gland salivary gland carcinoma ex pleomorphic adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A carcinoma that arises from a pleomorphic adenoma in the major salivary glands. It usually originates in the parotid gland. Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months. Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis. In cases where there is invasion of the surrounding tissues, the clinical course is aggressive."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006285"
    },
    {
      "id": 7829,
      "label": "major salivary gland mucoepidermoid carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7827,
        20263
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000346",
          "GARD:0024360",
          "MEDGEN:233139",
          "NCIT:C5906",
          "UMLS:C1334551"
        ],
        "synonyms": [
          "major salivary gland mucoepidermoid cancer",
          "major salivary gland mucoepidermoid carcinoma",
          "mucoepidermoid carcinoma of Major salivary gland",
          "mucoepidermoid carcinoma of the Major salivary gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A carcinoma that arises from the major salivary glands. It usually arises from the parotid gland. It is the most common primary carcinoma of the salivary glands and usually presents as a firm and painless mass. It is characterized by the presence of epidermoid cells, mucus producing cells, and cells of intermediate type. The majority of cases have a favorable outcome."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006286"
    },
    {
      "id": 20311,
      "label": "sublingual gland carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6451,
        7827
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027877",
          "MEDGEN:83385",
          "NCIT:C8397",
          "SCTID:254466003",
          "UMLS:C0345611"
        ],
        "synonyms": [
          "sublingual gland cancer",
          "carcinoma of sublingual gland",
          "carcinoma of the sublingual gland",
          "sublingual gland carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A carcinoma that arises from the sublingual gland. Representative examples include cystadenocarcinoma and mucoepidermoid carcinoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0021070"
    },
    {
      "id": 20508,
      "label": "carcinoma of parotid gland",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6480,
        7827
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000460",
          "GARD:0027893",
          "MEDGEN:91047",
          "NCIT:C6791",
          "SCTID:254462001",
          "UMLS:C0345602"
        ],
        "synonyms": [
          "parotid gland cancer",
          "carcinoma of parotid",
          "carcinoma of parotid gland",
          "carcinoma of the parotid",
          "carcinoma of the parotid gland",
          "parotid carcinoma",
          "parotid gland carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A carcinoma that involves the parotid gland."
      },
      "child_count": 10,
      "reference_id": "MONDO:0021331"
    },
    {
      "id": 23547,
      "label": "major salivary gland adenoid cystic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5139,
        7827
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025941",
          "MEDGEN:235286",
          "NCIT:C5905",
          "UMLS:C1334548"
        ],
        "synonyms": [
          "adenoid cystic carcinoma of major salivary gland",
          "adenoid cystic carcinoma of the major salivary gland",
          "major salivary gland adenoid cystic cancer",
          "major salivary gland adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "An aggressive carcinoma that arises from the major salivary glands. It is characterized by the presence of malignant epithelial and myoepithelial cells forming cribriform, tubular, and solid patterns. It usually presents as a slow growing mass. Patients develop pain because of the tendency of these carcinomas to invade perineural tissues."
      },
      "child_count": 6,
      "reference_id": "MONDO:0045063"
    }
  ],
  "roots": [
    {
      "id": 2972,
      "label": "salivary gland carcinoma"
    },
    {
      "id": 23418,
      "label": "major salivary gland cancer"
    }
  ]
}