{
  "id": 7831,
  "label": "malignant adrenal gland pheochromocytoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006288",
  "properties": {
    "xrefs": [
      "DOID:0080347",
      "EFO:1000348",
      "GARD:0024362",
      "ICDO:8700/3",
      "MEDGEN:87238",
      "NCIT:C4220",
      "SCTID:21851000119103",
      "UMLS:C0334419"
    ],
    "synonyms": [
      "adrenal gland pheochromocytoma, malignant",
      "malignant adrenal gland Chromaffinoma",
      "malignant adrenal gland chromaffin neoplasm",
      "malignant adrenal gland chromaffin paraganglioma",
      "malignant adrenal gland chromaffin tumor",
      "malignant adrenal gland chromaffin tumour",
      "malignant adrenal gland paraganglioma",
      "malignant adrenal gland pheochromocytoma",
      "malignant adrenal medullary paraganglioma",
      "malignant adrenal medullary pheochromocytoma",
      "malignant adrenal pheochromocytoma",
      "malignant pheochromocytoma",
      "pheochromoblastoma",
      "pheochromocytoma, malignant"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A pheochromocytoma that metastasizes to other anatomic sites. Common sites of metastasis include lymph nodes, bones, liver, and lung. Morphologic features associated with malignant pheochromocytomas include: atypical mitotic figures, capsular and vascular invasion, tumor cell necrosis, and high mitotic activity."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1800",
          "GARD:0023067",
          "ICDO:8246/3",
          "MEDGEN:104919",
          "MESH:D018278",
          "NCIT:C3773",
          "SCTID:253000007",
          "UMLS:C0206695"
        ],
        "synonyms": [
          "NEC",
          "neuroendocrine cancer",
          "neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002120"
    },
    {
      "id": 4753,
      "label": "central nervous system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7479,
        7694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3620",
          "EFO:0000326",
          "GARD:0027614",
          "ICD9:239.7",
          "MEDGEN:87593",
          "MESH:D016543",
          "NANDO:2100007",
          "NCIT:C4627",
          "SCTID:126951006",
          "UMLS:C0348374"
        ],
        "synonyms": [
          "CNS neoplasm",
          "central nervous system tumor",
          "central nervous system tumour",
          "CNS cancer",
          "CNS malignant neoplasms",
          "CNS neoplasms, malignant",
          "cancer of CNS",
          "cancer of central nervous system",
          "cancer of the CNS",
          "cancer of the central nervous system",
          "central nervous system cancer",
          "central nervous system neoplasms, malignant",
          "central nervous system tumours",
          "malignant CNS neoplasm",
          "malignant CNS neoplasms",
          "malignant CNS tumor",
          "malignant CNS tumour",
          "malignant central nervous system neoplasm",
          "malignant central nervous system tumor",
          "malignant central nervous system tumour",
          "malignant neoplasm of CNS",
          "malignant neoplasm of central nervous system",
          "malignant neoplasm of the CNS",
          "malignant neoplasm of the central nervous system",
          "malignant tumor of CNS",
          "malignant tumor of central nervous system",
          "malignant tumor of the CNS",
          "malignant tumor of the central nervous system",
          "malignant tumour of CNS",
          "malignant tumour of central nervous system",
          "malignant tumour of the CNS",
          "malignant tumour of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the central nervous system"
      },
      "child_count": 40,
      "reference_id": "MONDO:0002714"
    },
    {
      "id": 6024,
      "label": "adrenal medulla carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4840,
        5499
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7379",
          "GARD:0023873"
        ],
        "synonyms": [
          "adrenal medulla carcinoma",
          "carcinoma of adrenal medulla"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the adrenal medulla"
      },
      "child_count": 4,
      "reference_id": "MONDO:0004202"
    },
    {
      "id": 6716,
      "label": "adrenal gland pheochromocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20313,
        20446
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050892",
          "EFO:0000239",
          "GARD:0024140",
          "ICDO:8700/0",
          "MEDGEN:1636437",
          "NANDO:2200078",
          "NCIT:C3326",
          "UMLS:C4551683"
        ],
        "synonyms": [
          "pheochromocytoma",
          "Intraadrenal paraganglioma",
          "PCC",
          "adrenal gland Chromaffinoma",
          "adrenal gland chromaffin paraganglioma",
          "adrenal gland paraganglioma",
          "adrenal gland pheochromocytoma",
          "adrenal medullary paraganglioma",
          "adrenal medullary pheochromocytoma",
          "adrenal pheochromocytoma",
          "chromaffin paraganglioma of the adrenal gland",
          "pheochromocytoma (adrenal)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system that secretes catecholamines. It arises from the chromaffin cells of the adrenal medulla. Clinical presentation includes headaches, palpitations, chest and abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic nesting (zellballen) growth pattern is usually seen. Other growth patterns including trabecular pattern may also be present."
      },
      "child_count": 6,
      "reference_id": "MONDO:0004974"
    },
    {
      "id": 20329,
      "label": "peripheral nervous system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3627,
        7479
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:171.9",
          "MEDGEN:155556",
          "NCIT:C4961",
          "SCTID:254986007",
          "UMLS:C0751428"
        ],
        "synonyms": [
          "cancer of peripheral nervous system",
          "malignant PNS neoplasm",
          "malignant PNS tumor",
          "malignant PNS tumour",
          "malignant neoplasm of PNS",
          "malignant neoplasm of peripheral nerve",
          "malignant neoplasm of peripheral nervous system",
          "malignant neoplasm of the PNS",
          "malignant neoplasm of the peripheral nerve",
          "malignant neoplasm of the peripheral nervous system",
          "malignant neoplasms, peripheral nerve",
          "malignant peripheral nerve neoplasm",
          "malignant peripheral nerve tumor",
          "malignant peripheral nerve tumour",
          "malignant peripheral nervous system neoplasm",
          "malignant peripheral nervous system tumor",
          "malignant peripheral nervous system tumour",
          "malignant tumor of PNS",
          "malignant tumor of peripheral nerve",
          "malignant tumor of peripheral nervous system",
          "malignant tumor of the PNS",
          "malignant tumor of the peripheral nerve",
          "malignant tumor of the peripheral nervous system",
          "malignant tumour of PNS",
          "malignant tumour of peripheral nerve",
          "malignant tumour of peripheral nervous system",
          "malignant tumour of the PNS",
          "malignant tumour of the peripheral nerve",
          "malignant tumour of the peripheral nervous system",
          "peripheral nervous system cancer",
          "peripheral nervous system neoplasms, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Malignant growth of cells in the peripheral nervous system (PNS)or Autonomic Nervous System (ANS), without specification as to location"
      },
      "child_count": 36,
      "reference_id": "MONDO:0021089"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma"
    },
    {
      "id": 4753,
      "label": "central nervous system cancer"
    },
    {
      "id": 6024,
      "label": "adrenal medulla carcinoma"
    },
    {
      "id": 6716,
      "label": "adrenal gland pheochromocytoma"
    },
    {
      "id": 20329,
      "label": "peripheral nervous system cancer"
    }
  ]
}