{
  "id": 7832,
  "label": "malignant germ cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006290",
  "properties": {
    "xrefs": [
      "EFO:1000352",
      "GARD:0003360",
      "MEDGEN:890580",
      "NCIT:C4925",
      "SCTID:145831000119103",
      "UMLS:C4048549"
    ],
    "synonyms": [
      "cancer of germ cell",
      "germ cell cancer",
      "germ cell tumor, malignant",
      "malignant germ cell neoplasm",
      "malignant germ cell tumor",
      "malignant neoplasm of germ cell",
      "malignant neoplasm of the germ cell",
      "malignant tumor of germ cell",
      "malignant tumor of the germ cell",
      "malignant tumour of germ cell",
      "malignant tumour of the germ cell"
    ],
    "definition": "A gonadal or extragonadal malignant neoplasm that arises from germ cells. Representative examples include embryonal carcinoma, yolk sac tumor, and seminoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 13,
  "parents": [
    {
      "id": 6733,
      "label": "cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050686",
          "DOID:0050687",
          "DOID:162",
          "ICD9:195.8",
          "ICD9:199",
          "ICD9:199.1",
          "ICDO:8000/3",
          "MEDGEN:14297",
          "NCIT:C9305",
          "ONCOTREE:MT",
          "SCTID:363346000",
          "UMLS:C0006826",
          "birnlex:406"
        ],
        "synonyms": [
          "CA",
          "cancer",
          "cell type cancer",
          "malignancy",
          "malignant growth",
          "malignant neoplasm",
          "malignant neoplasm (disease)",
          "malignant neoplastic disease",
          "malignant tumor",
          "malignant tumour",
          "neoplasm (disease), malignant",
          "neoplasm, malignant",
          "MT"
        ],
        "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas."
      },
      "child_count": 33,
      "reference_id": "MONDO:0004992"
    },
    {
      "id": 6773,
      "label": "germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2994",
          "EFO:0000514",
          "GARD:0013022",
          "MEDGEN:60030",
          "NCIT:C3708",
          "UMLS:C0205851"
        ],
        "synonyms": [
          "germ cell neoplasm",
          "germ cell tumor",
          "neoplasm of germ cell",
          "neoplasm of the germ cell",
          "tumor of germ cell",
          "tumor of the germ cell",
          "tumour of germ cell",
          "tumour of the germ cell",
          "germ cell cancer",
          "germ cells tumors",
          "germ cells tumours",
          "malignant tumour of the germ cell"
        ],
        "definition": "A benign or malignant, gonadal or extragonadal neoplasm that originates from germ cells. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor."
      },
      "child_count": 13,
      "reference_id": "MONDO:0005040"
    }
  ],
  "children": [
    {
      "id": 4654,
      "label": "germinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7832
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3304",
          "GARD:0023182",
          "HP:0100620",
          "ICDO:9064/3",
          "MEDGEN:64626",
          "MESH:D018237",
          "NCIT:C3753",
          "ONCOTREE:GMN",
          "UMLS:C0206660"
        ],
        "synonyms": [
          "germinoma",
          "germinoma (disease)"
        ],
        "definition": "A malignant germ cell tumor arising in the central nervous system. It is characterized by the presence of primitive, large malignant germ cells and lymphocytes."
      },
      "child_count": 1,
      "reference_id": "MONDO:0002598"
    },
    {
      "id": 5000,
      "label": "seminoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7832,
        20017
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4440",
          "GARD:0023322",
          "ICD9:186.9",
          "ICDO:9061/3",
          "MEDGEN:11371",
          "MESH:D018239",
          "NCIT:C9309",
          "ONCOTREE:SEM",
          "SCTID:443675005",
          "UMLS:C0036631"
        ],
        "synonyms": [
          "seminoma",
          "seminoma, malignant",
          "seminoma, pure"
        ],
        "definition": "A radiosensitive malignant germ cell tumor found in the testis (especially undescended), and extragonadal sites (anterior mediastinum and pineal gland). It is characterized by the presence of uniform cells with clear or dense cytoplasm which contains glycogen, and by a large nucleus which contains one or more nucleoli. The neoplastic germ cells form aggregates separated by fibrous septa. The fibrous septa contain chronic inflammatory cells, mainly lymphocytes."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003001"
    },
    {
      "id": 5001,
      "label": "dysgerminoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7832,
        20017
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4441",
          "GARD:0023323",
          "HP:0100621",
          "ICDO:9060/3",
          "MEDGEN:41680",
          "MESH:D004407",
          "NANDO:2200066",
          "NCIT:C2996",
          "UMLS:C0013377",
          "icd11.foundation:817547820"
        ],
        "synonyms": [
          "dysgerminoma",
          "dysgerminoma (disease)",
          "dysgerminoma, malignant"
        ],
        "definition": "A malignant germ cell tumor characterized by the presence of a monotonous primitive germ cell population. The neoplastic cells form aggregates and have an abundant pale cytoplasm and uniform nuclei. The aggregates of the germ cells are separated by fibrous septa which contain inflammatory cells, mostly T-lymphocytes. It arises primarily in the ovaries, but can occur both primarily and secondarily at other sites, particularly the central nervous system. It responds to chemotherapy and radiotherapy. Its prognosis is related to the tumor stage."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003002"
    },
    {
      "id": 5094,
      "label": "extragonadal germ cell cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7832,
        18334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4717",
          "GARD:0023371",
          "MEDGEN:235292",
          "NCIT:C8881",
          "UMLS:C1334581"
        ],
        "synonyms": [
          "extragonadal germ cell malignant tumour",
          "extragonadal germ cell tumor, malignant",
          "malignant extragonadal germ cell tumor",
          "malignant extragonadal germ cell tumour",
          "malignant neoplasm of extragonadal germ cell",
          "malignant neoplasm of the extragonadal germ cell",
          "malignant tumor of extragonadal germ cell",
          "malignant tumor of the extragonadal germ cell",
          "malignant tumour of extragonadal germ cell",
          "malignant tumour of the extragonadal germ cell",
          "tumour of extragonadal germ cell"
        ],
        "definition": "A malignant germ cell tumor that develops as a primary tumor in an anatomic site other than the testis or ovary."
      },
      "child_count": 18,
      "reference_id": "MONDO:0003113"
    },
    {
      "id": 5420,
      "label": "pulmonary artery choriocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2933,
        6924,
        7832,
        23003
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5547",
          "GARD:0023535",
          "MEDGEN:233371",
          "NCIT:C5381",
          "UMLS:C1335571"
        ],
        "synonyms": [
          "choriocarcinoma of pulmonary artery",
          "choriocarcinoma of the pulmonary artery",
          "chorioepithelioma of pulmonary artery",
          "chorioepithelioma of the pulmonary artery",
          "pulmonary artery choriocarcinoma",
          "pulmonary artery choriocarcinoma (disease)",
          "pulmonary artery chorioepithelioma",
          "pulmonary artery syncytioma",
          "syncytioma of pulmonary artery",
          "syncytioma of the pulmonary artery"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A rare choriocarcinoma that arises from a pulmonary artery."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003506"
    },
    {
      "id": 5424,
      "label": "malignant testicular germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7111,
        7832,
        11294
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5556",
          "GARD:0023539",
          "ICD9:186.9",
          "MEDGEN:163616",
          "NCIT:C9063",
          "SCTID:713646001",
          "UMLS:C0855197"
        ],
        "synonyms": [
          "testicular cancer",
          "malignant germ cell neoplasm of testis",
          "malignant germ cell neoplasm of the testis",
          "malignant germ cell tumor of testis",
          "malignant germ cell tumor of the testis",
          "malignant germ cell tumour of testis",
          "malignant germ cell tumour of the testis",
          "malignant testicular germ cell neoplasm",
          "malignant testicular germ cell tumor",
          "testicular ca. (no germ/tropho.)",
          "testicular cancer (excluding germ cell or trophoblastic cancer)",
          "testicular germ cell cancer",
          "testicular malignant germ cell cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant tumor predominantly affecting young men and often associated with cryptorchidism. Seminoma is the most frequently seen malignant testicular germ cell tumor, followed by embryonal carcinoma and yolk sac tumor."
      },
      "child_count": 18,
      "reference_id": "MONDO:0003510"
    },
    {
      "id": 5427,
      "label": "malignant teratoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4656,
        7832
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5563",
          "GARD:0023541",
          "MEDGEN:1652407",
          "NCIT:C4287",
          "UMLS:C4722083"
        ],
        "synonyms": [
          "teratoma, malignant",
          "malignant extragonadal teratoma"
        ],
        "definition": "A malignant form of teratoma."
      },
      "child_count": 14,
      "reference_id": "MONDO:0003514"
    },
    {
      "id": 6283,
      "label": "malignant childhood germ cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5631,
        7832,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8149",
          "GARD:0024027",
          "MEDGEN:233150",
          "NCIT:C6541",
          "UMLS:C1334574"
        ],
        "synonyms": [
          "malignant childhood germ cell neoplasm",
          "malignant paediatric germ cell tumour",
          "malignant pediatric germ cell tumor",
          "malignant childhood germ cell tumor",
          "malignant childhood germ cell tumour",
          "malignant paediatric germ cell neoplasm",
          "malignant pediatric germ cell neoplasm"
        ],
        "definition": "A malignant germ cell tumor that occurs during childhood."
      },
      "child_count": 36,
      "reference_id": "MONDO:0004479"
    },
    {
      "id": 16596,
      "label": "mixed germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7832
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3306",
          "GARD:0020202",
          "ICDO:9085/3",
          "MEDGEN:87257",
          "NANDO:2200071",
          "NCIT:C4290",
          "Orphanet:180234",
          "UMLS:C0334524"
        ],
        "synonyms": [
          "combined germ cell neoplasm",
          "combined germ cell tumor",
          "combined germ cell tumour",
          "mixed germ cell cancer",
          "mixed germ cell neoplasm",
          "mixed germ cell tumor"
        ],
        "definition": "A malignant germ cell tumor characterized by the presence of at least two different germ cell components. The different germ cell components include choriocarcinoma, embryonal carcinoma, yolk sac tumor, teratoma, and seminoma. It occurs in the ovary, testis, and extragonadal sites including central nervous system and mediastinum."
      },
      "child_count": 6,
      "reference_id": "MONDO:0015864"
    },
    {
      "id": 16721,
      "label": "vaginal germ cell malignant tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3623,
        7832
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020347",
          "MEDGEN:1670250",
          "Orphanet:206489",
          "UMLS:C4749402"
        ],
        "synonyms": [
          "vagina malignant germ cell tumor",
          "vagina malignant germ cell tumour",
          "vaginal germ cell cancer",
          "malignant germ cell tumor of the vagina",
          "malignant germ cell tumour of the vagina"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor that involves the vagina."
      },
      "child_count": 2,
      "reference_id": "MONDO:0016094"
    },
    {
      "id": 16836,
      "label": "malignant germ cell tumor of corpus uteri",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7594,
        7832
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020485",
          "MEDGEN:1655229",
          "Orphanet:213751",
          "UMLS:C4750753"
        ],
        "synonyms": [
          "body of uterus malignant germ cell tumor",
          "body of uterus malignant germ cell tumour",
          "germ cell cancer of corpus uteri",
          "germ cell cancer of the corpus uteri",
          "malignant germ cell tumor of the corpus uteri",
          "malignant germ cell tumour of the corpus uteri"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor that involves the body of uterus."
      },
      "child_count": 2,
      "reference_id": "MONDO:0016273"
    },
    {
      "id": 16845,
      "label": "malignant germ cell tumor of cervix uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4978,
        7832
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020501",
          "MEDGEN:1662294",
          "Orphanet:213837",
          "UMLS:C4750752"
        ],
        "synonyms": [
          "cervical germ cell cancer",
          "cervical malignant germ cell tumor",
          "cervical malignant germ cell tumour",
          "germ cell cancer of cervix uteri",
          "germ cell cancer of the cervix uteri",
          "uterine cervix malignant germ cell tumor",
          "uterine cervix malignant germ cell tumour",
          "malignant germ cell tumor of the cervix uteri",
          "malignant germ cell tumour of the cervix uteri"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor that involves the uterine cervix."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016289"
    },
    {
      "id": 18315,
      "label": "malignant germ cell tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7832,
        12476,
        18335,
        18448
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2155",
          "GARD:0009330",
          "MEDGEN:87544",
          "NCIT:C4514",
          "Orphanet:35807",
          "SCTID:254869000",
          "UMLS:C0346180"
        ],
        "synonyms": [
          "MOGCT",
          "malignant germ cell neoplasm of ovary",
          "malignant germ cell neoplasm of the ovary",
          "malignant germ cell tumor of ovary",
          "malignant germ cell tumor of the ovary",
          "malignant germ cell tumour of the ovary",
          "malignant ovarian germ cell neoplasm",
          "malignant ovarian germ cell tumor",
          "malignant ovarian germ cell tumour",
          "ovarian germ cell cancer",
          "ovary malignant germ cell tumor",
          "ovary malignant germ cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Malignant germ cell tumor of ovary is a rare ovarian cancer arising from germ cells in the ovary, frequently unilateral at diagnosis which characteristically presents during adolescence with pelvic mass, fever, vaginal bleeding and acute abdomen."
      },
      "child_count": 16,
      "reference_id": "MONDO:0018171"
    }
  ],
  "roots": [
    {
      "id": 6733,
      "label": "cancer"
    },
    {
      "id": 6773,
      "label": "germ cell tumor"
    }
  ]
}