{
  "id": 7834,
  "label": "malignant mesothelioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006292",
  "properties": {
    "xrefs": [
      "DOID:1790",
      "EFO:1000355",
      "GARD:0007026",
      "HP:0100001",
      "ICD9:199.1",
      "ICDO:9050/3",
      "MEDGEN:91062",
      "MESH:C562839",
      "MedDRA:10027406",
      "NCIT:C4456",
      "OMIM:156240",
      "Orphanet:50251",
      "SCTID:109378008",
      "UMLS:C0345967",
      "icd11.foundation:369414280"
    ],
    "synonyms": [
      "malignant mesothelial tumor",
      "malignant mesothelial tumour",
      "malignant mesothelioma",
      "malignant mesothelioma (disease)",
      "malignant neoplasm of mesothelium",
      "malignant neoplasm of the mesothelium",
      "malignant tumor of mesothelium",
      "malignant tumor of the mesothelium",
      "malignant tumour of mesothelium",
      "malignant tumour of the mesothelium",
      "mesothelioma, malignant",
      "mesothelioma, somatic",
      "advanced malignant mesothelioma",
      "asbestos-related malignant mesothelioma",
      "diffuse malignant mesothelioma",
      "malignant mesothelial neoplasm",
      "MESOM"
    ],
    "definition": "A malignant neoplasm of the pleura or peritoneum, arising from mesothelial cells. It is associated with exposure to asbestos."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 6733,
      "label": "cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050686",
          "DOID:0050687",
          "DOID:162",
          "ICD9:195.8",
          "ICD9:199",
          "ICD9:199.1",
          "ICDO:8000/3",
          "MEDGEN:14297",
          "NCIT:C9305",
          "ONCOTREE:MT",
          "SCTID:363346000",
          "UMLS:C0006826",
          "birnlex:406"
        ],
        "synonyms": [
          "CA",
          "cancer",
          "cell type cancer",
          "malignancy",
          "malignant growth",
          "malignant neoplasm",
          "malignant neoplasm (disease)",
          "malignant neoplastic disease",
          "malignant tumor",
          "malignant tumour",
          "neoplasm (disease), malignant",
          "neoplasm, malignant",
          "MT"
        ],
        "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas."
      },
      "child_count": 33,
      "reference_id": "MONDO:0004992"
    },
    {
      "id": 6794,
      "label": "mesothelioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8299
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0000588",
          "ICD10CM:C45",
          "MEDGEN:9975",
          "MESH:D008654",
          "NCIT:C3234",
          "UMLS:C0025500"
        ],
        "synonyms": [
          "mesothelioma"
        ],
        "definition": "A usually malignant and aggressive neoplasm of the mesothelium which is often associated with exposure to asbestos."
      },
      "child_count": 7,
      "reference_id": "MONDO:0005065"
    }
  ],
  "children": [
    {
      "id": 4342,
      "label": "ovarian malignant mesothelioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7834,
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2143",
          "GARD:0023089",
          "MEDGEN:274089",
          "NCIT:C40444",
          "UMLS:C1518721"
        ],
        "synonyms": [
          "malignant mesothelioma (disease) of ovary",
          "ovarian malignant mesothelioma",
          "ovary malignant mesothelioma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare malignant mesothelial neoplasm that usually involves both the ovarian surface and the ovarian stroma. In most cases there is bilateral ovarian involvement."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002223"
    },
    {
      "id": 5679,
      "label": "malignant pericardial mesothelioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3552,
        7834
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6201",
          "GARD:0023676",
          "HP:0100004",
          "MEDGEN:233322",
          "NCIT:C7631",
          "Orphanet:685004",
          "SCTID:109383000",
          "UMLS:C1335381"
        ],
        "synonyms": [
          "malignant mesothelioma (disease) of pericardium",
          "malignant mesothelioma of pericardium",
          "malignant mesothelioma of the pericardium",
          "pericardial malignant mesothelioma",
          "pericardium malignant mesothelioma (disease)",
          "pericardium mesothelioma",
          "pericardial mesothelioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A rare neoplasm of mesothelial origin that arises from the pericardium."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003805"
    },
    {
      "id": 6838,
      "label": "malignant pleural mesothelioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5249,
        7834,
        7835
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7474",
          "EFO:0000770",
          "GARD:0024150",
          "MEDGEN:208810",
          "NCIT:C7376",
          "SCTID:254645002",
          "UMLS:C0812413"
        ],
        "synonyms": [
          "pleura mesothelioma",
          "malignant mesothelioma of pleura",
          "malignant mesothelioma of the pleura",
          "malignant pleural mesothelioma",
          "pleural diffuse malignant mesothelioma",
          "pleural malignant mesothelioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A malignant neoplasm that arises from mesothelial cells in the pleura and shows a diffuse growth pattern. It arises on the parietal and sometimes visceral pleura as multiple small nodules that later become confluent and invade the chest wall adipose tissue and muscle. Asbestos exposure is the main cause for the development of pleural malignant mesothelioma. It usually affects patients over sixty years of age. The latency period is long. Patients usually present with pleural effusion, dyspnea and chest wall pain. Additional signs and symptoms include chills, sweating, weight loss, and weakness. Morphologic variants include epithelioid, desmoplastic, sarcomatoid, and biphasic mesothelioma. The clinical course is usually aggressive."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005112"
    },
    {
      "id": 7168,
      "label": "malignant peritoneal mesothelioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4227,
        7834,
        7887
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1788",
          "EFO:0005567",
          "GARD:0020102",
          "MEDGEN:83406",
          "MedDRA:10056558",
          "NCIT:C8704",
          "Orphanet:168811",
          "UMLS:C0346109"
        ],
        "synonyms": [
          "advanced malignant mesothelioma of peritoneum",
          "advanced malignant mesothelioma of the peritoneum",
          "advanced peritoneal malignant mesothelioma",
          "diffuse malignant peritoneal mesothelioma",
          "malignant mesothelioma (disease) of peritoneum",
          "malignant peritoneal mesothelioma, advanced",
          "peritoneal mesothelioma (disease), malignant",
          "peritoneum malignant mesothelioma (disease)",
          "primary malignant peritoneal mesothelioma",
          "peritoneal mesothelioma"
        ],
        "definition": "An aggressive malignant mesothelioma that arises from the peritoneum. Patients usually present with abdominal pain and ascites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005512"
    },
    {
      "id": 7243,
      "label": "malignant epithelioid mesothelioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7834
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4489",
          "EFO:0006452",
          "GARD:0024208",
          "ICDO:9052/3",
          "MEDGEN:163578",
          "NCIT:C7985",
          "UMLS:C0862312"
        ],
        "synonyms": [
          "epithelial mesothelioma",
          "epithelioid mesothelioma",
          "epithelioid mesothelioma, malignant",
          "epithelioid mesothelioma, malignant (morphologic abnormality)",
          "malignant epithelial mesothelioma"
        ],
        "definition": "A malignant neoplasm arising from mesothelial cells in the pleura. It is characterized by the presence of neoplastic cells with an epithelioid appearance. In the majority of cases, the neoplastic epithelioid cells lack significant cytologic atypia; mitotic figures are infrequently seen. In a minority of cases, the neoplastic cells are poorly differentiated and there is evidence of nuclear atypia and increased mitotic activity."
      },
      "child_count": 1,
      "reference_id": "MONDO:0005599"
    },
    {
      "id": 7680,
      "label": "malignant biphasic mesothelioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7834
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4486",
          "EFO:1000124",
          "GARD:0024296",
          "ICDO:9053/3",
          "MEDGEN:137775",
          "NCIT:C4282",
          "UMLS:C0334515"
        ],
        "synonyms": [
          "biphasic mesothelioma",
          "malignant biphasic mesothelioma",
          "malignant biphasic mesothelioma, malignant",
          "malignant mixed mesothelioma",
          "mesothelioma, biphasic, malignant (morphologic abnormality)",
          "mixed mesothelioma"
        ],
        "definition": "A malignant neoplasm arising from mesothelial cells in the pleura. It is characterized by the presence of neoplastic epithelioid cells and sarcomatoid features."
      },
      "child_count": 1,
      "reference_id": "MONDO:0006109"
    },
    {
      "id": 7926,
      "label": "sarcomatoid mesothelioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7834
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4488",
          "EFO:1000521",
          "GARD:0024401",
          "MEDGEN:137774",
          "NCIT:C45655",
          "UMLS:C0334513"
        ],
        "synonyms": [
          "malignant fibrous mesothelioma (morphologic abnormality)",
          "sarcomatoid mesothelioma",
          "sarcomatoid mesothelioma (morphologic abnormality)"
        ],
        "definition": "A diffuse malignant mesothelioma arising from the pleura and less often the peritoneum. It is characterized by the presence of spindle cells. Anaplastic morphologic features and multinucleated malignant cells may also be seen."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006407"
    },
    {
      "id": 26068,
      "label": "localized pleural mesothelioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7834
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027199",
          "MEDGEN:1863756",
          "Orphanet:675833",
          "UMLS:C5925094"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0971141"
    },
    {
      "id": 26069,
      "label": "diffused pleural mesothelioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7834
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027200",
          "MEDGEN:1863751",
          "Orphanet:675837",
          "UMLS:C5925095"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0971142"
    },
    {
      "id": 26070,
      "label": "pleural mesothelioma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7834
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027201",
          "MEDGEN:1805153",
          "Orphanet:675841",
          "UMLS:C5668165"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0971143"
    },
    {
      "id": 26153,
      "label": "mesothelioma of the tunica vaginalis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7834
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027408",
          "MEDGEN:782172",
          "Orphanet:685010",
          "UMLS:C3494988"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0975890"
    }
  ],
  "roots": [
    {
      "id": 6733,
      "label": "cancer"
    },
    {
      "id": 6794,
      "label": "mesothelioma"
    }
  ]
}