{
  "id": 7835,
  "label": "pleural cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006294",
  "properties": {
    "xrefs": [
      "DOID:5158",
      "EFO:1000362",
      "ICD10CM:C38.4",
      "ICD9:163",
      "ICD9:163.8",
      "ICD9:163.9",
      "MEDGEN:56307",
      "NCIT:C3547",
      "SCTID:363433009",
      "UMLS:C0153494"
    ],
    "synonyms": [
      "neoplasm of pleura",
      "pleural tumor",
      "pleural tumour",
      "cancer of pleura",
      "cancer of the pleura",
      "malignant neoplasm of pleura",
      "malignant neoplasm of the pleura",
      "malignant pleura neoplasm",
      "malignant pleural neoplasm",
      "malignant pleural tumor",
      "malignant pleural tumour",
      "malignant tumor of pleura",
      "malignant tumor of the pleura",
      "malignant tumour of pleura",
      "malignant tumour of the pleura",
      "pleura cancer",
      "pleural cancer"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A primary or metastatic malignant neoplasm affecting the pleura. A representative example of primary malignant pleural neoplasm is the malignant pleural mesothelioma. A representative example of metastatic malignant neoplasm to the pleura is metastatic carcinoma that has spread to the pleura from another anatomic site."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 2875,
      "label": "respiratory system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        6815
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050615",
          "ICD10CM:C34",
          "ICD9:165.8",
          "ICD9:165.9",
          "MEDGEN:756863",
          "NCIT:C4571",
          "SCTID:449096009",
          "UMLS:C3164456",
          "icd11.foundation:401100796"
        ],
        "synonyms": [
          "cancer of respiratory system",
          "malignant neoplasm of respiratory system",
          "malignant respiratory system neoplasm",
          "respiratory system cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the respiratory system"
      },
      "child_count": 18,
      "reference_id": "MONDO:0000376"
    },
    {
      "id": 5215,
      "label": "thoracic cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20518
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5093",
          "ICD10CM:C76.1",
          "ICD9:195.1",
          "MEDGEN:56320",
          "NCIT:C3576",
          "SCTID:188361007",
          "UMLS:C0153661"
        ],
        "synonyms": [
          "thoracic tumor",
          "thoracic tumour",
          "thorax neoplasm",
          "tumor of thorax",
          "tumour of thorax",
          "cancer of thoracic segment of trunk",
          "malignant neoplasm of the thorax",
          "malignant neoplasm of thoracic segment of trunk",
          "malignant neoplasm of thorax",
          "malignant thoracic neoplasm",
          "malignant thoracic segment of trunk neoplasm",
          "malignant thoracic tumor",
          "malignant thoracic tumour",
          "malignant tumor of the thorax",
          "malignant tumor of thorax",
          "malignant tumour of the thorax",
          "malignant tumour of thorax",
          "thoracic segment of trunk cancer"
        ],
        "definition": "A primary or metastatic malignant neoplasm affecting the tissues of the thorax."
      },
      "child_count": 16,
      "reference_id": "MONDO:0003274"
    },
    {
      "id": 20306,
      "label": "pleural neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4184,
        20056
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:18523",
          "MESH:D010997",
          "NCIT:C3332",
          "ONCOTREE:PLEURA",
          "SCTID:126719004",
          "UMLS:C0032229"
        ],
        "synonyms": [
          "neoplasm of pleura",
          "neoplasm of pleural cavity",
          "neoplasm of the pleura",
          "pleura neoplasm",
          "pleura neoplasm (disease)",
          "pleura tumor",
          "pleura tumour",
          "pleural cavity neoplasm (disease)",
          "pleural cavity tumor",
          "pleural cavity tumour",
          "pleural neoplasm",
          "pleural tumor",
          "pleural tumour",
          "tumor of pleura",
          "tumor of the pleura",
          "tumour of pleura",
          "tumour of the pleura"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that involves the serous membrane that lines the lungs and thoracic cavity. Most pleural neoplasms are metastatic. Diffuse malignant mesothelioma is the most common primary malignant neoplasm of the pleura."
      },
      "child_count": 10,
      "reference_id": "MONDO:0021065"
    }
  ],
  "children": [
    {
      "id": 2896,
      "label": "malignant pleural solitary fibrous tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7835,
        20286
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050695",
          "GARD:0022766",
          "MEDGEN:1876517",
          "UMLS:C5985025"
        ],
        "synonyms": [
          "pleural solitary fibrous tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A malignant form of pleural solitary fibrous tumor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000407"
    },
    {
      "id": 4038,
      "label": "malignant parietal pleura tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7835
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14032",
          "MEDGEN:509310",
          "SCTID:93948004",
          "UMLS:C0153495"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001861"
    },
    {
      "id": 4039,
      "label": "malignant visceral pleura tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7835
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14033",
          "MEDGEN:509311",
          "SCTID:94140004",
          "UMLS:C0153496"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001862"
    },
    {
      "id": 6838,
      "label": "malignant pleural mesothelioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5249,
        7834,
        7835
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7474",
          "EFO:0000770",
          "GARD:0024150",
          "MEDGEN:208810",
          "NCIT:C7376",
          "SCTID:254645002",
          "UMLS:C0812413"
        ],
        "synonyms": [
          "pleura mesothelioma",
          "malignant mesothelioma of pleura",
          "malignant mesothelioma of the pleura",
          "malignant pleural mesothelioma",
          "pleural diffuse malignant mesothelioma",
          "pleural malignant mesothelioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A malignant neoplasm that arises from mesothelial cells in the pleura and shows a diffuse growth pattern. It arises on the parietal and sometimes visceral pleura as multiple small nodules that later become confluent and invade the chest wall adipose tissue and muscle. Asbestos exposure is the main cause for the development of pleural malignant mesothelioma. It usually affects patients over sixty years of age. The latency period is long. Patients usually present with pleural effusion, dyspnea and chest wall pain. Additional signs and symptoms include chills, sweating, weight loss, and weakness. Morphologic variants include epithelioid, desmoplastic, sarcomatoid, and biphasic mesothelioma. The clinical course is usually aggressive."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005112"
    }
  ],
  "roots": [
    {
      "id": 2875,
      "label": "respiratory system cancer"
    },
    {
      "id": 5215,
      "label": "thoracic cancer"
    },
    {
      "id": 20306,
      "label": "pleural neoplasm"
    }
  ]
}