{
  "id": 7836,
  "label": "malignant urinary system neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006295",
  "properties": {
    "xrefs": [
      "DOID:3996",
      "EFO:1000363",
      "ICD10CM:C64-C68",
      "ICD9:189.9",
      "MEDGEN:738719",
      "NCIT:C192668",
      "NCIT:C9297",
      "SCTID:448233000",
      "UMLS:C1644719"
    ],
    "synonyms": [
      "cancer of renal system",
      "malignant neoplasm of renal system",
      "malignant renal system neoplasm",
      "malignant urinary system neoplasm",
      "malignant urinary tract neoplasm",
      "renal system cancer",
      "urinary system cancer"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "A primary or metastatic malignant tumor involving the urinary system. Common tumor types include carcinomas, lymphomas, and sarcomas."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 6733,
      "label": "cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050686",
          "DOID:0050687",
          "DOID:162",
          "ICD9:195.8",
          "ICD9:199",
          "ICD9:199.1",
          "ICDO:8000/3",
          "MEDGEN:14297",
          "NCIT:C9305",
          "ONCOTREE:MT",
          "SCTID:363346000",
          "UMLS:C0006826",
          "birnlex:406"
        ],
        "synonyms": [
          "CA",
          "cancer",
          "cell type cancer",
          "malignancy",
          "malignant growth",
          "malignant neoplasm",
          "malignant neoplasm (disease)",
          "malignant neoplastic disease",
          "malignant tumor",
          "malignant tumour",
          "neoplasm (disease), malignant",
          "neoplasm, malignant",
          "MT"
        ],
        "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas."
      },
      "child_count": 33,
      "reference_id": "MONDO:0004992"
    },
    {
      "id": 20307,
      "label": "urinary system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4253,
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:239.5",
          "MEDGEN:52949",
          "NCIT:C192666",
          "NCIT:C3431",
          "ONCOTREE:BLADDER",
          "SCTID:126879004",
          "UMLS:C0042076"
        ],
        "synonyms": [
          "neoplasm of renal system",
          "neoplasm of the urinary system",
          "neoplasm of the urinary tract",
          "neoplasm of urinary system",
          "neoplasm of urinary tract",
          "renal system neoplasm",
          "renal system neoplasm (disease)",
          "renal system tumor",
          "renal system tumour",
          "tumor of renal system",
          "tumor of the urinary system",
          "tumor of the urinary tract",
          "tumor of urinary system",
          "tumor of urinary tract",
          "tumour of renal system",
          "tumour of the urinary system",
          "tumour of the urinary tract",
          "tumour of urinary system",
          "tumour of urinary tract",
          "urinary system neoplasm",
          "urinary system tumor",
          "urinary system tumour",
          "urinary tract neoplasm",
          "urinary tract tumor",
          "urinary tract tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A benign or malignant, primary or metastatic neoplasm involving the urinary system. --2003"
      },
      "child_count": 16,
      "reference_id": "MONDO:0021066"
    }
  ],
  "children": [
    {
      "id": 3260,
      "label": "malignant prostate phyllodes tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7836,
        9621,
        20342,
        22955
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10289",
          "GARD:0022859",
          "MEDGEN:235301",
          "NCIT:C5531",
          "UMLS:C1334615"
        ],
        "synonyms": [
          "malignant phyllodes neoplasm of prostate",
          "malignant phyllodes neoplasm of the prostate",
          "malignant phyllodes tumor of prostate",
          "malignant phyllodes tumor of the prostate",
          "malignant phyllodes tumour of prostate",
          "malignant phyllodes tumour of the prostate",
          "malignant prostate phyllodes neoplasm",
          "malignant prostate phyllodes tumor",
          "prostate malignant phyllodes tumor",
          "prostate malignant phyllodes tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An unusual malignant tumor that arises from the prostate gland. It is characterized by the presence of glandular elements and a cellular stroma that exhibits mitotic activity and nuclear atypia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000994"
    },
    {
      "id": 3431,
      "label": "urinary bladder cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6728,
        7836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11054",
          "ICD10CM:C67",
          "ICD9:188",
          "ICD9:188.8",
          "ICD9:188.9",
          "MEDGEN:14150",
          "NCIT:C9334",
          "OMIM:109800",
          "Orphanet:157980",
          "SCTID:399326009",
          "UMLS:C0005684",
          "icd11.foundation:1244512758"
        ],
        "synonyms": [
          "tumor of the bladder",
          "tumour of the bladder",
          "bladder cancer, somatic",
          "cancer of urinary bladder",
          "malignant bladder neoplasm",
          "malignant bladder tumor",
          "malignant bladder tumour",
          "malignant neoplasm of bladder",
          "malignant neoplasm of the bladder",
          "malignant neoplasm of the urinary bladder",
          "malignant neoplasm of urinary bladder",
          "malignant neoplasm, bladder",
          "malignant neoplasm, urinary bladder",
          "malignant tumor of bladder",
          "malignant tumor of the bladder",
          "malignant tumor of the urinary bladder",
          "malignant tumor of urinary bladder",
          "malignant tumor, urinary bladder",
          "malignant tumour of bladder",
          "malignant tumour of the bladder",
          "malignant tumour of the urinary bladder",
          "malignant tumour of urinary bladder",
          "malignant urinary bladder neoplasm",
          "malignant urinary bladder tumor",
          "malignant urinary bladder tumour",
          "urinary bladder cancer",
          "urinary bladder malignant neoplasm",
          "urinary bladder malignant tumor",
          "urinary bladder malignant tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the bladder."
      },
      "child_count": 18,
      "reference_id": "MONDO:0001187"
    },
    {
      "id": 4465,
      "label": "kidney cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7836,
        20396
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:263",
          "ICD9:189.0",
          "MEDGEN:149263",
          "MESH:D007680",
          "NCIT:C7548",
          "SCTID:363518003",
          "UMLS:C0740457"
        ],
        "synonyms": [
          "cancer of kidney",
          "kidney cancer",
          "malignant kidney neoplasm",
          "malignant kidney tumor",
          "malignant kidney tumour",
          "malignant neoplasm of kidney",
          "malignant neoplasm of the kidney",
          "malignant renal neoplasm",
          "malignant renal tumor",
          "malignant renal tumour",
          "malignant tumor of kidney",
          "malignant tumor of the kidney",
          "malignant tumour of the kidney"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Primary or metastatic malignant neoplasm involving the kidney."
      },
      "child_count": 16,
      "reference_id": "MONDO:0002367"
    },
    {
      "id": 6014,
      "label": "urethra cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7836,
        20448
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:734",
          "GARD:0009390",
          "ICD10CM:C68.0",
          "ICD9:189.3",
          "MEDGEN:57565",
          "NCIT:C7507",
          "ONCOTREE:UCA",
          "SCTID:363459007",
          "UMLS:C0153620",
          "icd11.foundation:1707814375"
        ],
        "synonyms": [
          "cancer of urethra",
          "malignant neoplasm of the urethra",
          "malignant neoplasm of urethra",
          "malignant tumor of the urethra",
          "malignant tumor of urethra",
          "malignant tumour of the urethra",
          "malignant urethra neoplasm",
          "malignant urethra tumor",
          "malignant urethra tumour",
          "malignant urethral neoplasm",
          "malignant urethral tumor",
          "malignant urethral tumour",
          "urethra cancer",
          "urethral cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the urethra"
      },
      "child_count": 10,
      "reference_id": "MONDO:0004192"
    },
    {
      "id": 9402,
      "label": "multiple endocrine neoplasia type 2B",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2903,
        7836,
        18918
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10016",
          "GARD:0010225",
          "ICD9:237.4",
          "ICD9:258.03",
          "MEDGEN:9959",
          "MESH:D018814",
          "MedDRA:10056420",
          "NANDO:2201053",
          "NCIT:C3227",
          "OMIM:162300",
          "Orphanet:247709",
          "SCTID:61530001",
          "UMLS:C0025269",
          "icd11.foundation:1754393919"
        ],
        "synonyms": [
          "MEN2B",
          "RET-related multiple endocrine neoplasia type 2B",
          "Wagenmann-Froboese syndrome",
          "men 2B",
          "men IIB",
          "men type 2B",
          "men type IIB",
          "multiple endocrine adenomatosis type IIB",
          "multiple endocrine neoplasia IIB",
          "multiple endocrine neoplasia type 2B",
          "multiple endocrine neoplasia type 3",
          "multiple endocrine neoplasia type IIB",
          "multiple endocrine neoplasia type III",
          "multiple endocrine neoplasia, type III",
          "Neuromata, mucosal, with endocrine tumors",
          "Neuromata, mucosal, with endocrine tumours",
          "mucosal Neuroma syndrome",
          "multiple endocrine neoplasia, type 2B",
          "multiple endocrine neoplasia, type 3 (formerly)",
          "multiple endocrine neoplasia, type IIB",
          "multiple endocrine neoplasia, type III, formerly"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An autosomal dominant disorder caused by specific pathogenic variants in the RET gene, characterized by an increased risk of very early onset medullary thyroid carcinoma, pheochromocytoma, and hyperparathyroidism, and mucosal neuromas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008082"
    },
    {
      "id": 9910,
      "label": "ureter cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7836,
        20350
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11819",
          "ICD10CM:C66",
          "ICD9:189.2",
          "MEDGEN:102281",
          "MESH:D014516",
          "NCIT:C7543",
          "OMIM:191600",
          "SCTID:363458004",
          "UMLS:C0153619"
        ],
        "synonyms": [
          "cancer of ureter",
          "malignant neoplasm of the ureter",
          "malignant neoplasm of ureter",
          "malignant tumor of the ureter",
          "malignant tumor of ureter",
          "malignant tumour of the ureter",
          "malignant ureter neoplasm",
          "malignant ureter tumor",
          "malignant ureter tumour",
          "malignant ureteral neoplasm",
          "malignant ureteral tumor",
          "malignant ureteral tumour",
          "ureter cancer",
          "ureter, cancer OF"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the ureter"
      },
      "child_count": 6,
      "reference_id": "MONDO:0008627"
    },
    {
      "id": 12245,
      "label": "pheochromocytoma/paraganglioma syndrome 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2903,
        2912,
        4753,
        7836,
        17682,
        20310,
        20329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0061217",
          "GARD:0010544",
          "MEDGEN:357076",
          "MESH:C566646",
          "OMIM:601650",
          "UMLS:C1866552"
        ],
        "synonyms": [
          "SDHAF2 paraganglioma",
          "SDHAF2-related tumor predisposition",
          "paraganglioma caused by mutation in SDHAF2",
          "paragangliomas 2",
          "paragangliomas type 2",
          "pheochromocytoma/paraganglioma syndrome 2",
          "PGL2",
          "SDHAF2-related hereditary paraganglioma-pheochromocytoma syndrome (paragangliomas 2)",
          "glomus tumors, familial, 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An autosomal dominant tumor predisposition disorder caused by pathogenic variants in the SDHAF2 gene, characterized by an increased risk of paraganglioma, particularly head and neck paragangliomas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011121"
    },
    {
      "id": 14628,
      "label": "pheochromocytoma/paraganglioma syndrome 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2912,
        4753,
        7836,
        17682,
        20310,
        20329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0061220",
          "GARD:0015763",
          "MEDGEN:481622",
          "OMIM:614165",
          "UMLS:C3279992"
        ],
        "synonyms": [
          "SDHA paraganglioma",
          "paraganglioma caused by mutation in SDHA",
          "paragangliomas 5",
          "paragangliomas type 5",
          "pheochromocytoma/paraganglioma syndrome 5",
          "PGL5"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Any paraganglioma in which the cause of the disease is a mutation in the SDHA gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013602"
    },
    {
      "id": 23005,
      "label": "infiltrating urothelial carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7836,
        21366,
        23004
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:268274",
          "NCIT:C39853",
          "UMLS:C1512751"
        ],
        "synonyms": [
          "infiltrating transitional cell carcinoma of the urinary tract",
          "infiltrating urothelial carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A invasive carcinoma that involves the urothelium."
      },
      "child_count": 6,
      "reference_id": "MONDO:0040678"
    },
    {
      "id": 23006,
      "label": "urothelial carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7836,
        7972,
        21366
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0008528",
          "GARD:0025829",
          "MEDGEN:760495",
          "NCIT:C4030",
          "UMLS:C2145472"
        ],
        "synonyms": [
          "Uroepithelial carcinoma",
          "transitional cell car. -uroth.",
          "transitional cell carcinoma of the urinary tract",
          "transitional cell carcinoma of the urothelial tract",
          "urothelial carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A malignant neoplasm derived from the transitional epithelium of the urinary tract (urinary bladder, ureter, urethra, or renal pelvis). It is frequently papillary."
      },
      "child_count": 15,
      "reference_id": "MONDO:0040679"
    }
  ],
  "roots": [
    {
      "id": 6733,
      "label": "cancer"
    },
    {
      "id": 20307,
      "label": "urinary system neoplasm"
    }
  ]
}