{
  "id": 7838,
  "label": "mediastinal malignant germ cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006298",
  "properties": {
    "xrefs": [
      "EFO:1000366",
      "GARD:0024365",
      "MEDGEN:277334",
      "NCIT:C6446",
      "SCTID:713293002",
      "UMLS:C1334597"
    ],
    "synonyms": [
      "malignant mediastinal germ cell tumor",
      "malignant mediastinal germ cell tumour",
      "mediastinal germ cell tumor, malignant",
      "mediastinal malignant germ cell tumor",
      "thymic malignant germ cell tumor",
      "thymic malignant germ cell tumour",
      "malignant germ cell neoplasm of mediastinum",
      "malignant germ cell neoplasm of the mediastinum",
      "malignant germ cell tumor of mediastinum",
      "malignant germ cell tumor of the mediastinum",
      "malignant germ cell tumour of mediastinum",
      "malignant germ cell tumour of the mediastinum",
      "malignant mediastinal germ cell neoplasm"
    ],
    "definition": "An extragonadal malignant germ cell tumor that arises from the mediastinum. This category includes seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, mixed germ cell tumors, and immature malignant teratoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 5094,
      "label": "extragonadal germ cell cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7832,
        18334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4717",
          "GARD:0023371",
          "MEDGEN:235292",
          "NCIT:C8881",
          "UMLS:C1334581"
        ],
        "synonyms": [
          "extragonadal germ cell malignant tumour",
          "extragonadal germ cell tumor, malignant",
          "malignant extragonadal germ cell tumor",
          "malignant extragonadal germ cell tumour",
          "malignant neoplasm of extragonadal germ cell",
          "malignant neoplasm of the extragonadal germ cell",
          "malignant tumor of extragonadal germ cell",
          "malignant tumor of the extragonadal germ cell",
          "malignant tumour of extragonadal germ cell",
          "malignant tumour of the extragonadal germ cell",
          "tumour of extragonadal germ cell"
        ],
        "definition": "A malignant germ cell tumor that develops as a primary tumor in an anatomic site other than the testis or ovary."
      },
      "child_count": 18,
      "reference_id": "MONDO:0003113"
    },
    {
      "id": 7455,
      "label": "mediastinal cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5215,
        20542
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5559",
          "EFO:0007362",
          "ICD9:164.9",
          "MEDGEN:56308",
          "MESH:D008479",
          "NCIT:C3549",
          "SCTID:363494000",
          "UMLS:C0153504"
        ],
        "synonyms": [
          "mediastinal tumor",
          "mediastinal tumour",
          "tumor of mediastinum",
          "tumour of mediastinum",
          "cancer of mediastinum",
          "cancer of the mediastinum",
          "malignant mediastinal neoplasm",
          "malignant mediastinal tumor",
          "malignant mediastinal tumour",
          "malignant mediastinum neoplasm",
          "malignant neoplasm of mediastinum",
          "malignant neoplasm of the mediastinum",
          "malignant tumor of mediastinum",
          "malignant tumor of the mediastinum",
          "malignant tumour of mediastinum",
          "malignant tumour of the mediastinum",
          "mediastinal cancer",
          "mediastinum cancer"
        ],
        "definition": "A malignant neoplasm involving the mediastinum"
      },
      "child_count": 12,
      "reference_id": "MONDO:0005843"
    },
    {
      "id": 20308,
      "label": "mediastinal germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18334,
        20542
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025285",
          "MEDGEN:233678",
          "NCIT:C6437",
          "UMLS:C1334655"
        ],
        "synonyms": [
          "germ cell neoplasm of mediastinum",
          "germ cell neoplasm of the mediastinum",
          "germ cell tumor of mediastinum",
          "germ cell tumor of the mediastinum",
          "germ cell tumour of mediastinum",
          "germ cell tumour of the mediastinum",
          "mediastinal germ cell neoplasm",
          "mediastinal germ cell tumor",
          "mediastinum germ cell tumor",
          "mediastinum germ cell tumour",
          "thymic germ cell tumor",
          "thymic germ cell tumour"
        ],
        "definition": "A germ cell tumor that arises from the mediastinum. Representative examples include seminoma, embryonal carcinoma, yolk sac tumor, teratoma, and mixed germ cell tumor."
      },
      "child_count": 4,
      "reference_id": "MONDO:0021067"
    }
  ],
  "children": [
    {
      "id": 5695,
      "label": "mediastinum seminoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5553,
        7838
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6249",
          "GARD:0023685",
          "MEDGEN:277355",
          "NCIT:C6812",
          "UMLS:C1334680"
        ],
        "synonyms": [
          "mediastinal seminoma",
          "mediastinum seminoma",
          "seminoma of mediastinum",
          "seminoma of the mediastinum"
        ],
        "definition": "An extragonadal malignant germ cell tumor that arises from the mediastinum. It is characterized by the presence of uniform cells with clear or eosinophilic cytoplasm, round nucleus with one or more nucleoli, and distinct cellular borders. It usually arises from the anterior mediastinum. It may present with respiratory distress, chest pain, or superior vena cava syndrome or it may be asymptomatic, with the tumor detected on routine chest x-ray. The prognosis of mediastinal pure seminomas is favorable compared to the mediastinal non-seminomatous malignant germ cell tumors."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003826"
    },
    {
      "id": 20474,
      "label": "malignant teratoma of mediastinum",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5427,
        5431,
        5475,
        7838
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025306",
          "MEDGEN:91164",
          "NCIT:C4668",
          "SCTID:278042005",
          "UMLS:C0349663"
        ],
        "synonyms": [
          "immature malignant teratoma of mediastinum",
          "immature malignant teratoma of the mediastinum",
          "malignant mediastinal teratoma",
          "malignant teratoma of the mediastinum",
          "mediastinal immature malignant teratoma",
          "mediastinum malignant teratoma"
        ],
        "definition": "A malignant teratoma that involves the mediastinum."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021283"
    },
    {
      "id": 21273,
      "label": "mediastinal yolk sac tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7365,
        7838
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008258",
          "MEDGEN:233176",
          "NCIT:C6443",
          "UMLS:C1334683"
        ],
        "synonyms": [
          "endodermal sinus neoplasm of mediastinum",
          "endodermal sinus neoplasm of the mediastinum",
          "endodermal sinus tumor of mediastinum",
          "endodermal sinus tumor of the mediastinum",
          "endodermal sinus tumour of mediastinum",
          "endodermal sinus tumour of the mediastinum",
          "mediastinal endodermal sinus neoplasm",
          "mediastinal endodermal sinus tumor",
          "mediastinal endodermal sinus tumour",
          "mediastinal yolk Sac neoplasm",
          "mediastinal yolk Sac tumor",
          "mediastinal yolk Sac tumour",
          "mediastinum yolk sac tumor",
          "mediastinum yolk sac tumour",
          "yolk Sac neoplasm of mediastinum",
          "yolk Sac neoplasm of the mediastinum",
          "yolk Sac tumor of mediastinum",
          "yolk Sac tumor of the mediastinum",
          "yolk Sac tumour of mediastinum",
          "yolk Sac tumour of the mediastinum",
          "EST",
          "mediastinal endodermal sinus tumors",
          "mediastinal endodermal sinus tumours"
        ],
        "definition": "An extragonadal non-seminomatous malignant germ cell tumor that arises from the mediastinum. It is characterized by the presence of small pale cells with small amount of cytoplasm and round to oval nuclei with small nucleoli forming a variety of patterns, including microcystic, macrocystic, pseudopapillary, myxomatous, hepatoid, polyvesicular vitelline, and solid. It manifests with respiratory distress, thoracic pain, fever, and superior vena cava syndrome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0023726"
    }
  ],
  "roots": [
    {
      "id": 5094,
      "label": "extragonadal germ cell cancer"
    },
    {
      "id": 7455,
      "label": "mediastinal cancer"
    },
    {
      "id": 20308,
      "label": "mediastinal germ cell tumor"
    }
  ]
}