{
  "id": 7847,
  "label": "myelodysplastic/myeloproliferative neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006311",
  "properties": {
    "xrefs": [
      "DOID:4972",
      "EFO:1000388",
      "GARD:0024368",
      "ICDO:9975/3",
      "MEDGEN:226981",
      "NCIT:C27262",
      "ONCOTREE:MDS%2FMPN",
      "SCTID:445738007",
      "UMLS:C1301355"
    ],
    "synonyms": [
      "MDS-MPD",
      "MDS/MPD",
      "myelodysplastic myeloproliferative disease",
      "myelodysplastic/myeloproliferative disease",
      "myelodysplastic/myeloproliferative diseases",
      "myelodysplastic/myeloproliferative disorder",
      "myelodysplastic/myeloproliferative disorders",
      "myeloproliferative/myelodysplastic disorders",
      "myeloproliferative/myelodysplastic syndromes",
      "MDS/MPN",
      "MPD-MDS",
      "MPD/MDS",
      "myelodysplastic/myeloproliferative neoplasm",
      "myelodysplastic/myeloproliferative neoplasms"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A category of clonal hematopoietic disorders that have both myelodysplastic and myeloproliferative features at the time of initial presentation."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 19727,
      "label": "myeloproliferative neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6892,
        16513,
        20376
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2226",
          "EFO:0002428",
          "GARD:0009319",
          "ICD9:238.79",
          "ICDO:9960/3",
          "ICDO:9975/1",
          "MEDGEN:220955",
          "MedDRA:10028576",
          "NCIT:C4345",
          "ONCOTREE:MPN",
          "Orphanet:98274",
          "SCTID:425333006",
          "UMLS:C1292778"
        ],
        "synonyms": [
          "CMPD",
          "MPD",
          "MPN",
          "chronic myeloproliferative disease",
          "chronic myeloproliferative disorder",
          "chronic myeloproliferative neoplasm",
          "myeloproliferative disorder",
          "myeloproliferative neoplasm",
          "myeloproliferative neoplasm, chronic",
          "myeloproliferative tumor",
          "myeloproliferative tumour",
          "CMPD, U",
          "chronic myeloproliferative disorders",
          "myeloproliferative neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)"
      },
      "child_count": 39,
      "reference_id": "MONDO:0020076"
    }
  ],
  "children": [
    {
      "id": 6439,
      "label": "atypical chronic myeloid leukemia, BCR-ABL1 negative",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6429,
        7847,
        19728
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060597",
          "DOID:8747",
          "GARD:0019583",
          "ICDO:9876/3",
          "MEDGEN:266233",
          "MedDRA:10054651",
          "NCIT:C3519",
          "Orphanet:98824",
          "SCTID:277589003",
          "UMLS:C1292772",
          "icd11.foundation:331838766"
        ],
        "synonyms": [
          "aCML",
          "atypical CML",
          "atypical chronic myeloid leukaemia",
          "atypical chronic myeloid leukemia",
          "atypical chronic myeloid leukemia, BCR-ABL1 Negative",
          "subacute granulocytic leukaemia",
          "subacute granulocytic leukemia",
          "subacute myelogenous leukaemia",
          "subacute myelogenous leukemia",
          "subacute myeloid leukaemia",
          "subacute myeloid leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A myelodysplastic/myeloproliferative neoplasm characterized by the principal involvement of the neutrophil series with leukocytosis and multilineage dysplasia. The neoplastic cells do not have a Philadelphia chromosome or the BCR/ABL fusion gene. (WHO, 2001)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004653"
    },
    {
      "id": 19790,
      "label": "chronic myelomonocytic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3274,
        7847,
        19728
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080188",
          "EFO:1001779",
          "GARD:0008225",
          "ICD10CM:C93.1",
          "ICDO:9945/3",
          "MEDGEN:44125",
          "MESH:D015477",
          "MedDRA:10009018",
          "NANDO:2200014",
          "NCIT:C3178",
          "ONCOTREE:CMML",
          "Orphanet:98823",
          "SCTID:127225006",
          "UMLS:C0023480",
          "icd11.foundation:2073226578"
        ],
        "synonyms": [
          "CMML",
          "chronic myelomonocytic leukaemia (CMML)",
          "chronic myelomonocytic leukemia",
          "chronic myelomonocytic leukemia (CMML)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A myelodysplastic/myeloproliferative neoplasm which is characterized by persistent monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer than 20 percent blasts in the bone marrow and blood, myelodysplasia, and absence of PDGFRA or PDGFRB rearrangement."
      },
      "child_count": 3,
      "reference_id": "MONDO:0020311"
    }
  ],
  "roots": [
    {
      "id": 19727,
      "label": "myeloproliferative neoplasm"
    }
  ]
}