{
  "id": 7851,
  "label": "neuroblastic tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006316",
  "properties": {
    "xrefs": [
      "EFO:1000393",
      "MEDGEN:233228",
      "NCIT:C6963",
      "UMLS:C1334953"
    ],
    "synonyms": [
      "neuroblastic tumor"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A group of nervous system tumors which display neuronal differentiation. It includes tumors that are composed of immature round cells and tumors that display advanced differentiation and the formation of ganglion cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 7121,
      "label": "primitive neuroectodermal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7212,
        20418
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:171",
          "EFO:0005235",
          "ICDO:9473/3",
          "ICDO:9503/3",
          "MEDGEN:64627",
          "MESH:D017599",
          "NCIT:C3716",
          "ONCOTREE:PNET",
          "UMLS:C0206663"
        ],
        "synonyms": [
          "PNET",
          "neuroectodermal neoplasm",
          "neuroectodermal tumor",
          "neuroectodermal tumour",
          "primitive neuroectodermal neoplasm",
          "primitive neuroectodermal tumor",
          "primitive neuroectodermal tumor (PNET)",
          "primitive neuroectodermal tumour (PNET)",
          "neuroepithelioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm constitutes the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems and includes some glial cell precursors."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005462"
    }
  ],
  "children": [
    {
      "id": 6767,
      "label": "ganglioneuroma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3043,
        4464,
        7851,
        17182,
        20329,
        23497
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4817",
          "EFO:0000500",
          "GARD:0020731",
          "HP:0003005",
          "ICD9:215.9",
          "ICDO:9490/0",
          "MEDGEN:6545",
          "MedDRA:10017709",
          "NCIT:C3049",
          "ONCOTREE:GN",
          "Orphanet:251992",
          "SCTID:116371000119107",
          "UMLS:C0017075",
          "birnlex:12617"
        ],
        "synonyms": [
          "ganglioneuroma",
          "ganglioneuroma (Schwannian Stroma-dominant)",
          "ganglioneuroma (disease)",
          "ganglioneuroma, benign",
          "neural Crest tumor, benign",
          "GN"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign neuroblastic tumor of the sympathetic nervous system that occurs in childhood. Ganglioneuroma typically arises from the sympathetic trunk in the mediastinum. Histologic features include spindle cell proliferation (resembling a neurofibroma) and the presence of large ganglion cells. Common presenting features include a palpable abdominal mass, hepatomegaly, and a thoracic mass detected on routine chest X-ray."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005033"
    },
    {
      "id": 6769,
      "label": "ganglioneuroblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7851
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4163",
          "EFO:0000502",
          "GARD:0020719",
          "HP:0006747",
          "ICD9:171.9",
          "ICDO:9490/3",
          "MEDGEN:60218",
          "MESH:D018305",
          "MedDRA:10017708",
          "NANDO:2200041",
          "NCIT:C3790",
          "ONCOTREE:GNBL",
          "Orphanet:251877",
          "SCTID:116381000119105",
          "UMLS:C0206718",
          "birnlex:12633"
        ],
        "synonyms": [
          "ganglioneuroblastoma",
          "ganglioneuroblastoma (disease)",
          "ganglioneuroblastoma (morphologic abnormality)",
          "ganglioneuroblastoma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neuroblastic tumor characterized by the presence of neuroblastic cells, ganglion cells, and a stroma with Schwannian differentiation constituting more than fifty-percent of the tumor volume. There are two histologic subtypes identified: ganglioneuroblastoma, intermixed and ganglioneuroblastoma, nodular."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005035"
    },
    {
      "id": 6800,
      "label": "neuroblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7851,
        20691
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:769",
          "EFO:0000621",
          "GARD:0007185",
          "ICDO:9500/3",
          "MEDGEN:18012",
          "MESH:D009447",
          "MedDRA:10029260",
          "NANDO:2200040",
          "NCIT:C3270",
          "ONCOTREE:NBL",
          "Orphanet:635",
          "SCTID:432328008",
          "UMLS:C0027819",
          "birnlex:12631"
        ],
        "synonyms": [
          "neural Crest tumor, malignant",
          "neuroblastoma",
          "neuroblastoma (Schwannian Stroma-poor)",
          "neuroblastoma, malignant",
          "NB"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Neuroblastoma (NB) is the most common solid, extracranial childhood tumor. It is an aggressive pediatric cancer that originates from neural crest tissues of the sympathetic nervous system."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005072"
    }
  ],
  "roots": [
    {
      "id": 7121,
      "label": "primitive neuroectodermal tumor"
    }
  ]
}