{
  "id": 7858,
  "label": "ocular melanoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006325",
  "properties": {
    "xrefs": [
      "DOID:1752",
      "EFO:1000403",
      "GARD:0007236",
      "MEDGEN:107846",
      "NCIT:C8562",
      "ONCOTREE:OM",
      "UMLS:C0558356"
    ],
    "synonyms": [
      "eye melanoma",
      "eye melanoma (disease)",
      "eyeball of camera-type eye melanoma",
      "eyeball of camera-type eye melanoma (disease)",
      "melanoma (disease) of eyeball of camera-type eye",
      "melanoma of eye",
      "melanoma of the eye",
      "ocular melanoma",
      "OM"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "A melanoma that arises from the structures of the eye or ocular adnexa."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 4353,
      "label": "ocular cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3050,
        7266,
        20431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2174",
          "ICD9:190.8",
          "ICD9:239.89",
          "MEDGEN:105418",
          "MESH:D005134",
          "NCIT:C4767",
          "SCTID:371486001",
          "UMLS:C0496836"
        ],
        "synonyms": [
          "eye neoplasm",
          "neoplasm of eye",
          "ocular tumor",
          "ocular tumour",
          "cancer of eye",
          "cancer of eyeball of camera-type eye",
          "cancer of the eye",
          "eye cancer",
          "eye neoplasm, malignant",
          "eyeball of camera-type eye cancer",
          "malignant eye neoplasm",
          "malignant eye tumor",
          "malignant eye tumour",
          "malignant eyeball of camera-type eye neoplasm",
          "malignant neoplasm of eye",
          "malignant neoplasm of eyeball of camera-type eye",
          "malignant neoplasm of the eye",
          "malignant ocular neoplasm",
          "malignant ocular tumor",
          "malignant ocular tumour",
          "malignant tumor of eye",
          "malignant tumor of the eye",
          "malignant tumour of eye",
          "malignant tumour of the eye",
          "neoplasm of eye proper"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A benign or malignant neoplasm affecting the structures of the eye."
      },
      "child_count": 30,
      "reference_id": "MONDO:0002236"
    },
    {
      "id": 6832,
      "label": "melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1909",
          "EFO:0000756",
          "HP:0002861",
          "ICDO:8720/3",
          "MEDGEN:9944",
          "MESH:D008545",
          "NANDO:2200077",
          "NCIT:C3224",
          "ONCOTREE:MEL",
          "Orphanet:411533",
          "SCTID:372244006",
          "UMLS:C0025202"
        ],
        "synonyms": [
          "malignant melanoma",
          "melanoma",
          "melanoma (disease)",
          "melanoma, malignant"
        ],
        "definition": "A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain."
      },
      "child_count": 15,
      "reference_id": "MONDO:0005105"
    }
  ],
  "children": [
    {
      "id": 3198,
      "label": "eyelid melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6750,
        7858,
        20495
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10040",
          "GARD:0022848",
          "ICD9:172.1",
          "MEDGEN:90937",
          "NCIT:C4358",
          "SCTID:231834005",
          "UMLS:C0339116"
        ],
        "synonyms": [
          "eyelid melanoma",
          "eyelid melanoma (disease)",
          "malignant eyelid melanoma",
          "malignant melanoma of eyelid",
          "malignant melanoma of the eyelid",
          "melanoma (disease) of eyelid",
          "melanoma of eyelid",
          "melanoma of the eyelid"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A melanoma that arises from the upper or lower eyelid."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000928"
    },
    {
      "id": 4234,
      "label": "malignant conjunctival melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5378,
        7858
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1751",
          "EFO:1000204",
          "GARD:0010744",
          "MEDGEN:138060",
          "NCIT:C4550",
          "ONCOTREE:CM",
          "Orphanet:617910",
          "SCTID:255004001",
          "UMLS:C0346360"
        ],
        "synonyms": [
          "conjunctiva melanoma",
          "conjunctiva melanoma (disease)",
          "conjunctival malignant melanoma",
          "conjunctival melanoma",
          "malignant conjunctiva melanoma",
          "malignant conjunctival melanoma",
          "malignant melanoma of conjunctiva",
          "malignant melanoma of the conjunctiva",
          "melanoma (disease) of conjunctiva",
          "melanoma of conjunctiva",
          "melanoma of the conjunctiva",
          "CM"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A malignant melanoma within the conjunctiva of the eye."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002096"
    },
    {
      "id": 6349,
      "label": "malignant cornea melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5677,
        7858
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8400",
          "GARD:0027343",
          "MEDGEN:138061",
          "NCIT:C4553",
          "UMLS:C0346367"
        ],
        "synonyms": [
          "cornea melanoma",
          "cornea melanoma (disease)",
          "corneal melanoma",
          "malignant cornea melanoma",
          "malignant corneal melanoma",
          "malignant melanoma of cornea",
          "malignant melanoma of the cornea",
          "melanoma (disease) of cornea",
          "melanoma of cornea",
          "melanoma of the cornea"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A melanoma within the cornea of the eye."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004550"
    },
    {
      "id": 6359,
      "label": "retinal melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5060,
        7858
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8427",
          "GARD:0027344",
          "MEDGEN:163431",
          "NCIT:C8601",
          "SCTID:423673009",
          "UMLS:C0853394"
        ],
        "synonyms": [
          "malignant melanoma of retina",
          "malignant melanoma of the retina",
          "malignant retinal melanoma",
          "melanoma (disease) of retina",
          "melanoma of retina",
          "melanoma of the retina",
          "retina melanoma",
          "retina melanoma (disease)",
          "retinal melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A melanoma affecting the retinal portion of the eye. --2003"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004561"
    },
    {
      "id": 7859,
      "label": "ocular melanoma with extraocular extension",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7858
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027351",
          "MEDGEN:75884",
          "NCIT:C7913",
          "UMLS:C0278869"
        ],
        "synonyms": [
          "extraocular extension melanoma",
          "extraocular extension of melanoma",
          "ocular melanoma with extraocular extension"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A melanoma arising from and extending beyond the structures of the eye."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006326"
    },
    {
      "id": 7983,
      "label": "uveal melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4710,
        7858
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6039",
          "EFO:1000616",
          "GARD:0008621",
          "MEDGEN:65077",
          "MESH:C536494",
          "MedDRA:10061252",
          "NCIT:C7712",
          "OMIM:155720",
          "ONCOTREE:UM",
          "Orphanet:39044",
          "UMLS:C0220633"
        ],
        "synonyms": [
          "intraocular melanoma",
          "melanoma (disease) of uvea",
          "melanoma of the uvea",
          "melanoma of uvea",
          "melanoma, uveal, malignant",
          "uvea melanoma",
          "uvea melanoma (disease)",
          "uveal melanoma",
          "iris melanoma",
          "choroidal melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A melanoma derived from melanocytes of the uveal tract. It is the most common primary intraocular tumor in the United States and Western Europe. Similar to melanoma of the skin, it is rare in Africa and Asia. Diagnostic procedures include ophthalmoscopic exam, fluorescein angiography and ultrasound. Treatment includes: surgical excision of the eye, iridocyclectomy and tumor resection. Recent treatments also include radiotherapy or photo coagulation. Classification of uveal melanomas recognizes four cell types within these tumors: epithelioid, intermediate, mixed cell, and spindle cell types. The spindle cell type uveal melanomas are further sub-classified as spindle cell type A and spindle cell type B."
      },
      "child_count": 16,
      "reference_id": "MONDO:0006486"
    }
  ],
  "roots": [
    {
      "id": 4353,
      "label": "ocular cancer"
    },
    {
      "id": 6832,
      "label": "melanoma"
    }
  ]
}