{
  "id": 7869,
  "label": "ovarian transitional cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006343",
  "properties": {
    "xrefs": [
      "DOID:4000",
      "EFO:1000435",
      "GARD:0024373",
      "MEDGEN:233811",
      "NCIT:C5240",
      "UMLS:C1335184"
    ],
    "synonyms": [
      "ovarian transitional cell cancer",
      "ovarian transitional cell carcinoma",
      "ovary transitional cell carcinoma",
      "transitional cell carcinoma of ovary",
      "transitional cell carcinoma of the ovary"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma that arises from the ovary and is characterized by the presence of malignant epithelial cells that resemble malignant urothelial cells. There is no morphologic evidence of a benign or borderline Brenner tumor component present."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6864,
      "label": "ovarian carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4001",
          "EFO:0001075",
          "GARD:0024154",
          "MEDGEN:1648335",
          "NCIT:C4908",
          "UMLS:C4721610"
        ],
        "synonyms": [
          "ovarian cancer",
          "ovarian epithelial cancer",
          "carcinoma of ovary",
          "carcinoma of the ovary",
          "epithelial ovarian cancer",
          "ovarian carcinoma",
          "ovary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm originating from the surface ovarian epithelium. It accounts for the greatest number of deaths from malignancies of the female genital tract and is the fifth leading cause of cancer fatalities in women. It is predominantly a disease of older white women of northern European extraction, but it is seen in all ages and ethnic groups. Adenocarcinomas constitute the vast majority of ovarian carcinomas. The pattern of metastatic spread in ovarian carcinoma is similar regardless of the microscopic type. The most common sites of involvement are the contralateral ovary, peritoneal cavity, para-aortic and pelvic lymph nodes, and liver. Lung and pleura are the most common sites of extra-abdominal spread. The primary form of therapy is surgical. The overall prognosis of ovarian carcinoma remains poor, a direct result of its rapid growth rate and the lack of early symptoms. --2002"
      },
      "child_count": 9,
      "reference_id": "MONDO:0005140"
    },
    {
      "id": 7972,
      "label": "transitional cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2671",
          "EFO:1000601",
          "GARD:0007794",
          "ICDO:8120/3",
          "MEDGEN:2875",
          "MESH:D002295",
          "NCIT:C2930",
          "UMLS:C0007138"
        ],
        "synonyms": [
          "transitional cell neoplasm",
          "transitional cell tumor",
          "transitional cell tumour",
          "carcinoma of transitional epithelial cell",
          "carcinoma of urothelial cell",
          "carcinoma, urothelial, malignant",
          "transitional carcinoma",
          "transitional cell carcinoma",
          "transitional epithelial cell carcinoma",
          "urothelial cell carcinoma"
        ],
        "definition": "A malignant neoplasm arising from the transitional epithelium, usually affecting the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary configuration. It is graded 1 to 3 or 4 according to the degree of cellular differentiation and architectural patterns. Grade 1 transitional cell carcinoma is histologically benign but it may recur. Transitional cell carcinomas may also affect the upper respiratory tract and the ovaries."
      },
      "child_count": 9,
      "reference_id": "MONDO:0006474"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6864,
      "label": "ovarian carcinoma"
    },
    {
      "id": 7972,
      "label": "transitional cell carcinoma"
    }
  ]
}