{
  "id": 7870,
  "label": "ovarian yolk sac tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006344",
  "properties": {
    "xrefs": [
      "DOID:5350",
      "EFO:1000437",
      "GARD:0024374",
      "MEDGEN:83415",
      "NCIT:C8107",
      "ONCOTREE:OYST",
      "SCTID:254876005",
      "UMLS:C0346188"
    ],
    "synonyms": [
      "endodermal sinus neoplasm of ovary",
      "endodermal sinus neoplasm of the ovary",
      "endodermal sinus tumor of ovary",
      "endodermal sinus tumor of the ovary",
      "endodermal sinus tumour of the ovary",
      "germ cell endodermal sinus neoplasm of ovary",
      "germ cell endodermal sinus neoplasm of the ovary",
      "germ cell endodermal sinus tumor of ovary",
      "germ cell endodermal sinus tumor of the ovary",
      "germ cell endodermal sinus tumour of ovary",
      "germ cell endodermal sinus tumour of the ovary",
      "ovarian endodermal sinus neoplasm",
      "ovarian endodermal sinus tumor",
      "ovarian germ cell endodermal sinus neoplasm",
      "ovarian germ cell endodermal sinus tumor",
      "ovarian germ cell endodermal sinus tumour",
      "ovarian yolk Sac neoplasm",
      "ovarian yolk sac tumor",
      "ovary yolk sac tumor",
      "ovary yolk sac tumour",
      "yolk Sac neoplasm of ovary",
      "yolk Sac neoplasm of the ovary",
      "yolk Sac tumor of ovary",
      "yolk Sac tumor of the ovary",
      "yolk Sac tumour of ovary",
      "yolk Sac tumour of the ovary",
      "yolk sac tumor",
      "yolk sac tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A usually rapidly growing malignant germ cell tumor arising from the ovary. It usually occurs in children and adolescents. Signs and symptoms include abdominal pain and a large abdominal or pelvic mass. The serum alpha-fetoprotein is almost always elevated preoperatively. Morphologically, there is marked heterogeneity due to numerous patterns of differentiation coexisting in the same tumor. The most common pattern is reticular."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 7365,
      "label": "yolk sac tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5475
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1911",
          "EFO:0007252",
          "GARD:0000348",
          "ICDO:9071/3",
          "MEDGEN:41782",
          "MedDRA:10048251",
          "NANDO:2200069",
          "NCIT:C3011",
          "ONCOTREE:BYST",
          "Orphanet:876",
          "SCTID:404081005",
          "UMLS:C0014145"
        ],
        "synonyms": [
          "endodermal sinus neoplasm",
          "endodermal sinus tumor",
          "hepatoid yolk sac tumor",
          "yolk SAC tumor, malignant",
          "yolk Sac neoplasm",
          "yolk Sac tumor",
          "yolk Sac tumor site unspecified",
          "yolk Sac tumour site unspecified",
          "yolk sac tumor",
          "infantile embryonal carcinoma"
        ],
        "definition": "A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It is the most common malignant germ cell tumor in the pediatric population. It occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation, and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum."
      },
      "child_count": 7,
      "reference_id": "MONDO:0005744"
    },
    {
      "id": 16723,
      "label": "malignant non-dysgerminomatous germ cell tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5339,
        20708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020349",
          "MEDGEN:1826164",
          "NCIT:C102870",
          "Orphanet:206538",
          "UMLS:C5679783"
        ],
        "synonyms": [
          "non-dysgerminomatous germ cell cancer of ovary",
          "ovarian Nondysgerminomatous germ cell tumor",
          "ovarian Nondysgerminomatous germ cell tumour",
          "ovarian non-dysgerminomatous germ cell tumor",
          "ovarian non-dysgerminomatous germ cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor other than dysgerminoma that arises from the ovary."
      },
      "child_count": 10,
      "reference_id": "MONDO:0016096"
    }
  ],
  "children": [
    {
      "id": 5639,
      "label": "childhood ovarian yolk sac tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5332,
        5640,
        7870,
        20015
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6083",
          "GARD:0023654",
          "MEDGEN:234136",
          "NANDO:2200069",
          "NCIT:C6551",
          "UMLS:C1332993"
        ],
        "synonyms": [
          "childhood ovarian endodermal sinus neoplasm",
          "childhood ovarian yolk sac tumor",
          "ovary childhood endodermal sinus tumor",
          "ovary childhood endodermal sinus tumour",
          "pediatric ovarian yolk Sac tumor",
          "childhood ovarian endodermal sinus tumor",
          "childhood ovarian endodermal sinus tumour",
          "childhood ovarian yolk Sac neoplasm",
          "paediatric ovarian endodermal sinus neoplasm",
          "paediatric ovarian endodermal sinus tumour",
          "paediatric ovarian yolk Sac neoplasm",
          "pediatric ovarian endodermal sinus neoplasm",
          "pediatric ovarian endodermal sinus tumor",
          "pediatric ovarian yolk Sac neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the ovary and occurs in children."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003759"
    },
    {
      "id": 5767,
      "label": "ovarian yolk sac tumor, glandular pattern",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7870
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6511",
          "GARD:0023724",
          "MEDGEN:309520",
          "NCIT:C39988",
          "UMLS:C1518747"
        ],
        "synonyms": [
          "ovarian yolk Sac tumor, glandular pattern",
          "glandular pattern ovarian yolk sac tumor",
          "glandular pattern ovarian yolk sac tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the ovary and is characterized by the presence of extensive differentiation into endodermal type glandular structures."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003905"
    },
    {
      "id": 5768,
      "label": "ovarian yolk sac tumor, hepatoid pattern",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7870
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6512",
          "GARD:0023725",
          "MEDGEN:276676",
          "NCIT:C39989",
          "UMLS:C1518748"
        ],
        "synonyms": [
          "ovarian yolk Sac tumor, hepatoid pattern",
          "hepatoid pattern ovarian yolk sac tumor",
          "hepatoid pattern ovarian yolk sac tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the ovary and is characterized by the presence of extensive differentiation into hepatic tissue."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003906"
    },
    {
      "id": 5769,
      "label": "ovarian yolk sac tumor, polyvesicular vitelline pattern",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7870
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6514",
          "GARD:0023726",
          "MEDGEN:309521",
          "NCIT:C39987",
          "UMLS:C1518749"
        ],
        "synonyms": [
          "ovarian yolk sac tumor, polyvesicular vitelline pattern",
          "polyvesicular vitelline pattern ovarian yolk sac tumor",
          "polyvesicular vitelline pattern ovarian yolk sac tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the ovary and is characterized by the presence of multiple dilated spaces lined by cells that resemble mesothelial cells. The dilated spaces coexist with columnar epithelial tissues."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003907"
    }
  ],
  "roots": [
    {
      "id": 7365,
      "label": "yolk sac tumor"
    },
    {
      "id": 16723,
      "label": "malignant non-dysgerminomatous germ cell tumor of ovary"
    }
  ]
}