{
  "id": 7873,
  "label": "pancreatic large cell neuroendocrine carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006347",
  "properties": {
    "xrefs": [
      "EFO:1000442",
      "GARD:0024376",
      "MEDGEN:459465",
      "NCIT:C95582",
      "UMLS:C2987239"
    ],
    "synonyms": [
      "large cell neuroendocrine carcinoma of pancreas",
      "pancreas large cell neuroendocrine carcinoma",
      "pancreatic large cell NEC",
      "pancreatic large cell NEC G3",
      "pancreatic large cell neuroendocrine carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. It is characterized by the presence of malignant large cells."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6787,
      "label": "large cell neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        6943
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050872",
          "EFO:0000563",
          "GARD:0024145",
          "ICDO:8013/3",
          "MEDGEN:220402",
          "NCIT:C6875",
          "ONCOTREE:LUNE",
          "UMLS:C1265996",
          "icd11.foundation:1278312485"
        ],
        "synonyms": [
          "LCNEC",
          "large cell NEC",
          "large cell neuroendocrine carcinoma",
          "large-cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005057"
    },
    {
      "id": 6912,
      "label": "exocrine pancreatic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4251,
        7738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4905",
          "EFO:0002618",
          "GARD:0027717",
          "MEDGEN:65917",
          "NCIT:C3850",
          "SCTID:372142002",
          "UMLS:C0235974"
        ],
        "synonyms": [
          "cancer of pancreas",
          "cancer of the pancreas",
          "exocrine cancer",
          "pancreas cancer",
          "pancreatic cancer",
          "carcinoma of exocrine pancreas",
          "carcinoma of the pancreas",
          "exocrine pancreas carcinoma",
          "pancreas carcinoma",
          "pancreatic cancer (not islets)",
          "pancreatic carcinoma, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the exocrine pancreas"
      },
      "child_count": 16,
      "reference_id": "MONDO:0005192"
    },
    {
      "id": 7497,
      "label": "pancreatic endocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        7431,
        7738,
        11035
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1798",
          "EFO:0007416",
          "GARD:0022056",
          "ICD10CM:C25.4",
          "ICD9:157.4",
          "ICDO:8150/3",
          "MEDGEN:233070",
          "MESH:D018273",
          "NCIT:C3770",
          "Orphanet:506098",
          "SCTID:254612002",
          "UMLS:C1328479"
        ],
        "synonyms": [
          "Pancreatic Neuroendocrine cancer",
          "carcinoma of endocrine pancreas",
          "carcinoma, islet cell, malignant",
          "endocrine pancreas carcinoma",
          "high grade pancreatic neuroendocrine carcinoma",
          "high-grade pancreatic neuroendocrine carcinoma",
          "islet cell cancer",
          "islet cell carcinoma",
          "islet cell carcinoma (morphologic abnormality)",
          "malignant islet cell tumor",
          "malignant islet cell tumour",
          "malignant neoplasm of islets of Langerhans",
          "malignant pancreatic endocrine tumor",
          "malignant pancreatic endocrine tumour",
          "pancreatic NEC",
          "pancreatic NEC G3",
          "pancreatic endocrine cancer",
          "pancreatic endocrine carcinoma",
          "pancreatic neuroendocrine carcinoma",
          "poorly differentiated pancreatic endocrine carcinoma",
          "poorly-differentiated NEN of pancreas",
          "poorly-differentiated neuroendocrine neoplasm of pancreas",
          "poorly-differentiated pancreatic NEN",
          "poorly-differentiated pancreatic neuroendocrine neoplasm",
          "neuroendocrine carcinoma of pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0005893"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6787,
      "label": "large cell neuroendocrine carcinoma"
    },
    {
      "id": 6912,
      "label": "exocrine pancreatic carcinoma"
    },
    {
      "id": 7497,
      "label": "pancreatic endocrine carcinoma"
    }
  ]
}