{
  "id": 7874,
  "label": "pancreatic small cell neuroendocrine carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006348",
  "properties": {
    "xrefs": [
      "EFO:1000444",
      "GARD:0024377",
      "MEDGEN:459466",
      "NCIT:C95583",
      "UMLS:C2987240"
    ],
    "synonyms": [
      "endocrine pancreas small cell carcinoma",
      "pancreatic small cell NEC",
      "pancreatic small cell NEC G3",
      "pancreatic small cell neuroendocrine carcinoma",
      "small cell carcinoma of endocrine pancreas"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. It is characterized by the presence of malignant small cells."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 2894,
      "label": "small cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050685",
          "EFO:0008524",
          "GARD:0022765",
          "ICDO:8041/3",
          "ICDO:8042/3",
          "MEDGEN:90748",
          "MESH:D018288",
          "NCIT:C3915",
          "NCIT:C4099",
          "SCTID:11010461000119101",
          "UMLS:C0334239"
        ],
        "synonyms": [
          "oat cell cancer",
          "oat cell carcinoma",
          "small cell NEC",
          "small cell cancer",
          "small cell car. (extrapulmonary)",
          "small cell carcinoma",
          "small cell carcinoma (extrapulmonary)",
          "small cell neuroendocrine carcinoma",
          "intermediate cell small cell carcinoma",
          "small cell carcinoma - intermediate cell",
          "small cell carcinoma, intermediate cell",
          "small cell carcinoma, intermediate cell (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine carcinoma composed of small malignant cells which are often said to resemble \"oat cells\" under the microscope. Small cell carcinoma most often affects the lungs. Clinically, this is often a rapidly growing cancer that spreads to distant sites early."
      },
      "child_count": 18,
      "reference_id": "MONDO:0000402"
    },
    {
      "id": 7497,
      "label": "pancreatic endocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        7431,
        7738,
        11035
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1798",
          "EFO:0007416",
          "GARD:0022056",
          "ICD10CM:C25.4",
          "ICD9:157.4",
          "ICDO:8150/3",
          "MEDGEN:233070",
          "MESH:D018273",
          "NCIT:C3770",
          "Orphanet:506098",
          "SCTID:254612002",
          "UMLS:C1328479"
        ],
        "synonyms": [
          "Pancreatic Neuroendocrine cancer",
          "carcinoma of endocrine pancreas",
          "carcinoma, islet cell, malignant",
          "endocrine pancreas carcinoma",
          "high grade pancreatic neuroendocrine carcinoma",
          "high-grade pancreatic neuroendocrine carcinoma",
          "islet cell cancer",
          "islet cell carcinoma",
          "islet cell carcinoma (morphologic abnormality)",
          "malignant islet cell tumor",
          "malignant islet cell tumour",
          "malignant neoplasm of islets of Langerhans",
          "malignant pancreatic endocrine tumor",
          "malignant pancreatic endocrine tumour",
          "pancreatic NEC",
          "pancreatic NEC G3",
          "pancreatic endocrine cancer",
          "pancreatic endocrine carcinoma",
          "pancreatic neuroendocrine carcinoma",
          "poorly differentiated pancreatic endocrine carcinoma",
          "poorly-differentiated NEN of pancreas",
          "poorly-differentiated neuroendocrine neoplasm of pancreas",
          "poorly-differentiated pancreatic NEN",
          "poorly-differentiated pancreatic neuroendocrine neoplasm",
          "neuroendocrine carcinoma of pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0005893"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 2894,
      "label": "small cell carcinoma"
    },
    {
      "id": 7497,
      "label": "pancreatic endocrine carcinoma"
    }
  ]
}