{
  "id": 7886,
  "label": "penile carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006360",
  "properties": {
    "xrefs": [
      "DOID:3449",
      "EFO:1000465",
      "GARD:0024383",
      "MEDGEN:208877",
      "NCIT:C9061",
      "SCTID:372106005",
      "UMLS:C0853105"
    ],
    "synonyms": [
      "cancer of penis",
      "cancer of the penis",
      "cancer penis",
      "penile cancer",
      "carcinoma of penis",
      "carcinoma of the penis",
      "penile carcinoma",
      "penis carcinoma",
      "penile cancer, adult"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A carcinoma that arises from epithelial cells of the penis"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 3554,
      "label": "penile cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7450,
        8333
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11615",
          "GARD:0009366",
          "ICD10CM:C60",
          "ICD9:187.3",
          "ICD9:187.4",
          "MEDGEN:102277",
          "NCIT:C7547",
          "Orphanet:398043",
          "SCTID:363516004",
          "UMLS:C0153601",
          "icd11.foundation:969101922"
        ],
        "synonyms": [
          "penile neoplasm",
          "cancer of penis",
          "malignant neoplasm of penis",
          "malignant neoplasm of the penis",
          "malignant penile neoplasm",
          "malignant penile tumor",
          "malignant penile tumour",
          "malignant penis neoplasm",
          "malignant tumor of penis",
          "malignant tumor of the penis",
          "malignant tumour of penis",
          "malignant tumour of the penis",
          "penile cancer",
          "penis cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm that affects the penis. Representative examples include penile carcinoma and penile sarcoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0001325"
    },
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    }
  ],
  "children": [
    {
      "id": 4704,
      "label": "Paget disease of the penis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7886,
        9488
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3448",
          "GARD:0021638",
          "MEDGEN:66374",
          "NCIT:C27817",
          "Orphanet:398053",
          "SCTID:398768004",
          "UMLS:C0221286"
        ],
        "synonyms": [
          "Paget disease of the penis",
          "Paget's disease of penis",
          "Paget's disease of the penis",
          "adenocarcinoma of penis",
          "penile adenocarcinoma",
          "penis Paget disease",
          "penis adenocarcinoma",
          "penis mammary Paget's disease",
          "adenocarcinoma of the penis",
          "penis Paget's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A premalignant condition morphologically characterized by the presence of the characteristic Paget cells in the intraepithelial tissue of the penis. It presents as a smooth raised reddish area that may or may not be painful. -- 2003"
      },
      "child_count": 0,
      "reference_id": "MONDO:0002653"
    },
    {
      "id": 4940,
      "label": "penis basal cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7027,
        7886
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4277",
          "GARD:0023306",
          "MEDGEN:275349",
          "NCIT:C39961",
          "UMLS:C1518949"
        ],
        "synonyms": [
          "basal cell carcinoma of the penis",
          "penile basal cell cancer",
          "penile basal cell carcinoma",
          "penis skin basal cell carcinoma",
          "skin basal cell carcinoma of penis",
          "skin of penis skin basal cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A basal cell carcinoma of the penis with an indolent clinical course. It is usually superficial and arises from the shaft and rarely the glans."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002935"
    },
    {
      "id": 18435,
      "label": "squamous cell carcinoma of penis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        7886
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5518",
          "GARD:0021639",
          "MEDGEN:116057",
          "NCIT:C7729",
          "ONCOTREE:PSCC",
          "Orphanet:398058",
          "SCTID:403468003",
          "UMLS:C0238348",
          "icd11.foundation:186592209"
        ],
        "synonyms": [
          "epidermoid carcinoma of penis",
          "epidermoid carcinoma of the penis",
          "epidermoid cell carcinoma of penis",
          "epidermoid cell carcinoma of the penis",
          "penile epidermoid carcinoma",
          "penile epidermoid cell carcinoma",
          "penile squamous car.(epidermoid)",
          "penile squamous carcinoma (epidermoid)",
          "penile squamous cell cancer",
          "penile squamous cell carcinoma",
          "penis squamous cell carcinoma",
          "squamous cell carcinoma of penis",
          "squamous cell carcinoma of the penis",
          "PSCC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma arising from the penis. It occurs chiefly in the squamous epithelium of the glans, coronal sulcus, and foreskin. Etiologic factors include phimosis, lichen sclerosus, smoking, ultraviolet irradiation, history of warts or condylomas, and lack of circumcision. Human papilloma virus is present in a subset of penile squamous cell carcinomas. Patients may present with an exophytic or flat ulcerative mass in the glans or a large primary tumor with inguinal nodal and skin metastases. Morphologic variants include the basaloid carcinoma, warty (condylomatous) carcinoma, verrucous carcinoma, and sarcomatoid (spindle cell) carcinoma. (WHO, 2004)"
      },
      "child_count": 10,
      "reference_id": "MONDO:0018352"
    }
  ],
  "roots": [
    {
      "id": 3554,
      "label": "penile cancer"
    },
    {
      "id": 6734,
      "label": "carcinoma"
    }
  ]
}