{
  "id": 7890,
  "label": "Peutz-Jeghers polyp",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006365",
  "properties": {
    "xrefs": [
      "EFO:1000470",
      "MEDGEN:141582",
      "NCIT:C4733",
      "UMLS:C0456487"
    ],
    "synonyms": [
      "Peutz Jeghers polyp",
      "Peutz-Jeghers polyp"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A hamartomatous polyp that occurs in the stomach, small and large intestines, and rarely within the esophagus, nasopharynx and the urinary tract. The Peutz-Jeghers polyps are grossly lobulated and dark. Microscopically, they have a central core of smooth muscle covered by mucosa. The smooth muscle shows tree-like branching. The question of whether or not the Peutz-Jeghers polyp is precancerous is a matter of controversy. The loss of heterozygosity on chromosome 19p (where the responsible gene LKB1 is located) suggests that the increased risk of malignancy may be due to malignant transformation from hamartoma to adenocarcinoma. --2002"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 7784,
      "label": "gastrointestinal hamartoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7993,
        20434,
        21327
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000280",
          "MEDGEN:474435",
          "NCIT:C96475",
          "UMLS:C3272802"
        ],
        "synonyms": [
          "gastrointestinal hamartoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A non-neoplastic, hamartomatous polyp that arises from the stomach, small intestine, and large intestine. This group includes the juvenile polyps and Peutz-Jeghers polyps."
      },
      "child_count": 12,
      "reference_id": "MONDO:0006231"
    }
  ],
  "children": [
    {
      "id": 7891,
      "label": "Peutz-Jeghers polyp of the stomach",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7777,
        7890
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:233323",
          "NCIT:C36205",
          "UMLS:C1335398"
        ],
        "synonyms": [
          "Gastric Peutz-Jeghers polyp"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A non-neoplastic polyp that arises from the stomach and is characterized by the presence of smooth muscle branching bands, and hyperplasia with cystic dilatation of the foveolar epithelium."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006366"
    }
  ],
  "roots": [
    {
      "id": 7784,
      "label": "gastrointestinal hamartoma"
    }
  ]
}