{
  "id": 7896,
  "label": "pituitary gland adenoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006373",
  "properties": {
    "xrefs": [
      "DOID:3829",
      "EFO:1000478",
      "GARD:0019680",
      "ICDO:8272/0",
      "MEDGEN:45933",
      "MedDRA:10035079",
      "NANDO:2200095",
      "NCIT:C3329",
      "ONCOTREE:PTAD",
      "Orphanet:99408",
      "SCTID:254956000",
      "UMLS:C0032000"
    ],
    "synonyms": [
      "adenoma of pituitary",
      "adenoma of pituitary gland",
      "adenoma of the pituitary",
      "adenoma of the pituitary gland",
      "adenoma, anterior lobe pituitary gland, benign",
      "pituitary adenoma",
      "pituitary gland adenoma",
      "PTAD"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A non-metastasizing tumor that arises from the adenohypophysial cells of the anterior lobe of the pituitary gland. The tumor can be hormonally functioning or not. The diagnosis can be based on imaging studies and/or radioimmunoassays. Due to its location in the sella turcica, expansion of the tumor mass can impinge on the optic chiasm or involve the temporal lobe, third ventricle and posterior fossa A frequently associated physical finding is bitemporal hemianopsia which may progress to further visual loss."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 6714,
      "label": "adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:657",
          "EFO:0000232",
          "ICDO:8140/0",
          "MEDGEN:125",
          "MESH:D000236",
          "NCIT:C2855",
          "SCTID:443416007",
          "UMLS:C0001430"
        ],
        "synonyms": [
          "adenoma",
          "acinar cell adenoma",
          "acinar cell adenoma (morphologic abnormality)",
          "adenoma, benign"
        ],
        "definition": "A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated but non-invasive. The neoplastic epithelial cells may or may not display cellular atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes severe it is sometimes called carcinoma in situ. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract."
      },
      "child_count": 31,
      "reference_id": "MONDO:0004972"
    },
    {
      "id": 17888,
      "label": "pituitary tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        4759,
        5314,
        7638,
        8247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021253",
          "ICD9:239.7",
          "MEDGEN:19326",
          "NCIT:C3330",
          "Orphanet:304055",
          "SCTID:127024001",
          "UMLS:C0032019"
        ],
        "synonyms": [
          "neoplasm of pituitary",
          "neoplasm of pituitary gland",
          "neoplasm of the pituitary",
          "neoplasm of the pituitary gland",
          "pituitary gland neoplasm",
          "pituitary gland tumor",
          "pituitary gland tumour",
          "pituitary neoplasm",
          "pituitary tumor",
          "tumor of pituitary",
          "tumor of pituitary gland",
          "tumor of the pituitary",
          "tumor of the pituitary gland",
          "tumour of pituitary",
          "tumour of pituitary gland",
          "tumour of the pituitary",
          "tumour of the pituitary gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm affecting the pituitary gland. The vast majority are adenomas arising from the anterior lobe of the pituitary gland."
      },
      "child_count": 45,
      "reference_id": "MONDO:0017611"
    }
  ],
  "children": [
    {
      "id": 5357,
      "label": "functioning pituitary gland adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5498,
        7896
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5395",
          "GARD:0021389",
          "MEDGEN:163135",
          "NCIT:C8388",
          "Orphanet:314753",
          "UMLS:C0854486"
        ],
        "synonyms": [
          "endocrine active pituitary adenoma",
          "functioning adenoma of pituitary",
          "functioning adenoma of pituitary gland",
          "functioning adenoma of the pituitary",
          "functioning adenoma of the pituitary gland",
          "functioning pituitary adenoma",
          "functioning pituitary gland adenoma",
          "functioning pituitary gland adenoma (benign)",
          "secreting pituitary adenoma",
          "secretory adenoma of pituitary",
          "secretory adenoma of pituitary gland",
          "secretory adenoma of the pituitary",
          "secretory adenoma of the pituitary gland",
          "secretory pituitary adenoma",
          "secretory pituitary gland adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hormone producing pituitary gland adenoma, associated with a hormonal syndrome."
      },
      "child_count": 10,
      "reference_id": "MONDO:0003429"
    },
    {
      "id": 5962,
      "label": "pituitary gland mixed eosinophil-basophil adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7896
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7179",
          "GARD:0023841",
          "ICDO:8281/0",
          "MEDGEN:87215",
          "NCIT:C4148",
          "UMLS:C0334312"
        ],
        "synonyms": [
          "mixed acidophil-basophil adenoma",
          "mixed acidophil-basophil adenoma (morphologic abnormality)",
          "pituitary gland mixed acidophil-basophil adenoma",
          "mixed eosinophil-basophil adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic and basic dyes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004133"
    },
    {
      "id": 7648,
      "label": "ACTH-producing pituitary gland adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7896,
        23544
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000066",
          "GARD:0024280",
          "MEDGEN:266291",
          "NCIT:C7462",
          "UMLS:C1306214"
        ],
        "synonyms": [
          "ACTH producing pituitary gland adenoma",
          "ACTH secreting adenoma of pituitary",
          "ACTH secreting adenoma of the pituitary",
          "ACTH-producing pituitary adenoma",
          "ACTH-producing pituitary gland adenoma",
          "ACTH-secreting adenoma of pituitary",
          "ACTH-secreting adenoma of pituitary gland",
          "ACTH-secreting adenoma of the pituitary",
          "ACTH-secreting adenoma of the pituitary gland",
          "ACTHoma",
          "Corticotropinoma",
          "adrenocorticotropin producing adenoma of pituitary",
          "adrenocorticotropin producing adenoma of pituitary gland",
          "adrenocorticotropin producing adenoma of the pituitary",
          "adrenocorticotropin producing adenoma of the pituitary gland",
          "adrenocorticotropin producing pituitary adenoma",
          "adrenocorticotropin producing pituitary gland adenoma",
          "adrenocorticotropin secreting adenoma of pituitary",
          "adrenocorticotropin secreting adenoma of pituitary gland",
          "adrenocorticotropin secreting adenoma of the pituitary",
          "adrenocorticotropin secreting adenoma of the pituitary gland",
          "adrenocorticotropin secreting pituitary adenoma",
          "adrenocorticotropin secreting pituitary gland adenoma",
          "corticotroph adenoma",
          "corticotropic adenoma",
          "corticotropin secreting adenoma of the pituitary",
          "corticotropin secreting pituitary gland adenoma",
          "pituitary ACTH secreting adenoma",
          "pituitary ACTH-secreting adenoma",
          "pituitary corticotropin secreting adenoma",
          "pituitary gland ACTH-secreting adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenoma of the pituitary gland that produces corticotropin. The vast majority of cases are associated with Cushing disease. Clinical manifestations include truncal obesity with thin extremities, thinning of the skin, osteoporosis, and a tendency to bruise easily. Silent or hormonally non-functioning ACTH producing adenomas have also been described. They produce symptoms of a mass-related lesion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006068"
    },
    {
      "id": 7790,
      "label": "growth hormone-producing pituitary gland adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7896,
        19647
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6255",
          "EFO:1000287",
          "GARD:0016850",
          "MEDGEN:82999",
          "NANDO:1200385",
          "NANDO:1200386",
          "NCIT:C7461",
          "Orphanet:96256",
          "SCTID:254957009",
          "UMLS:C0278864"
        ],
        "synonyms": [
          "GH cell adenoma",
          "Somatotrophinoma",
          "growth hormone producing adenoma of pituitary",
          "growth hormone producing adenoma of pituitary gland",
          "growth hormone producing adenoma of the pituitary gland",
          "growth hormone producing pituitary adenoma",
          "growth hormone producing pituitary gland adenoma",
          "growth hormone secreting adenoma of pituitary",
          "growth hormone secreting adenoma of pituitary gland",
          "growth hormone secreting adenoma of the pituitary",
          "growth hormone secreting adenoma of the pituitary gland",
          "growth hormone secreting pituitary gland adenoma",
          "growth hormone-producing adenoma",
          "growth hormone-producing pituitary gland adenoma",
          "somatotrope adenoma",
          "somatotropic adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenoma of the anterior lobe of the pituitary gland that produces growth hormone. The vast majority of cases are hormonally functioning and are associated with either gigantism or acromegaly."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006238"
    },
    {
      "id": 8106,
      "label": "pituitary gland acidophil adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7896
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5392",
          "EFO:1000791",
          "GARD:0024448",
          "ICDO:8280/0",
          "MEDGEN:1748",
          "MESH:D000239",
          "NCIT:C6780",
          "UMLS:C0001433"
        ],
        "synonyms": [
          "acidophil adenoma",
          "eosinophil adenoma",
          "pituitary gland acidophil adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic dyes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006634"
    },
    {
      "id": 8142,
      "label": "pituitary gland basophil adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5530,
        6569,
        7896
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4542",
          "EFO:1000834",
          "GARD:0024457",
          "ICDO:8300/0",
          "MEDGEN:1746",
          "MESH:D000237",
          "NCIT:C2856",
          "UMLS:C0001431"
        ],
        "synonyms": [
          "basophilic adenoma",
          "basophilic pituitary gland adenoma",
          "mucoid cell adenoma",
          "pituitary basophilic adenoma",
          "basophil adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with basic dyes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006673"
    },
    {
      "id": 8164,
      "label": "chromophobe adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7896
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3828",
          "EFO:1000867",
          "GARD:0024460",
          "ICDO:8270/0",
          "MEDGEN:1747",
          "MESH:D000238",
          "NCIT:C2857",
          "UMLS:C0001432"
        ],
        "synonyms": [
          "chromophobe adenoma of pituitary gland",
          "chromophobe adenoma of the pituitary gland",
          "pituitary chromophobe adenoma",
          "pituitary gland chromophobe adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells do not stain with acidic or basic dyes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006701"
    },
    {
      "id": 18043,
      "label": "familial isolated pituitary adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7896,
        21247,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010959",
          "MEDGEN:436629",
          "OMIMPS:102200",
          "Orphanet:314777",
          "SCTID:702375004",
          "UMLS:C2676191"
        ],
        "synonyms": [
          "FIPA"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 18,
      "reference_id": "MONDO:0017824"
    },
    {
      "id": 19405,
      "label": "non-functioning pituitary adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5497,
        7896
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5715",
          "EFO:0008516",
          "GARD:0019159",
          "NCIT:C4348",
          "Orphanet:91349",
          "SCTID:254962005",
          "icd11.foundation:1197752358"
        ],
        "synonyms": [
          "NFPA",
          "functionless adenoma of pituitary",
          "functionless adenoma of pituitary gland",
          "functionless adenoma of the pituitary",
          "functionless adenoma of the pituitary gland",
          "functionless pituitary adenoma",
          "functionless pituitary gland adenoma",
          "non-functioning adenoma of pituitary",
          "non-functioning adenoma of pituitary gland",
          "non-functioning adenoma of the pituitary",
          "non-functioning adenoma of the pituitary gland",
          "non-functioning pituitary adenoma",
          "non-functioning pituitary gland adenoma",
          "non-secretory adenoma of pituitary",
          "non-secretory adenoma of pituitary gland",
          "non-secretory adenoma of the pituitary",
          "non-secretory adenoma of the pituitary gland",
          "non-secretory pituitary adenoma",
          "non-secretory pituitary gland adenoma",
          "nonfunctional pituitary gland adenoma",
          "silent pituitary gland adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hormone producing or non-producing pituitary gland adenoma not associated with a hormonal syndrome."
      },
      "child_count": 4,
      "reference_id": "MONDO:0019613"
    }
  ],
  "roots": [
    {
      "id": 6714,
      "label": "adenoma"
    },
    {
      "id": 17888,
      "label": "pituitary tumor"
    }
  ]
}