{
  "id": 7900,
  "label": "pleural epithelioid mesothelioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006378",
  "properties": {
    "xrefs": [
      "EFO:1000484",
      "GARD:0024387",
      "MEDGEN:318031",
      "NCIT:C45662",
      "UMLS:C1709574"
    ],
    "synonyms": [
      "malignant epithelioid mesothelioma of pleura",
      "pleura malignant epithelioid mesothelioma",
      "pleural epithelioid mesothelioma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "Malignant mesothelioma that arises from the pleura and is characterized by the presence of cells with epithelioid morphology. The epithelioid cells usually have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, or sheet-like patterns."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6838,
      "label": "malignant pleural mesothelioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5249,
        7834,
        7835
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7474",
          "EFO:0000770",
          "GARD:0024150",
          "MEDGEN:208810",
          "NCIT:C7376",
          "SCTID:254645002",
          "UMLS:C0812413"
        ],
        "synonyms": [
          "pleura mesothelioma",
          "malignant mesothelioma of pleura",
          "malignant mesothelioma of the pleura",
          "malignant pleural mesothelioma",
          "pleural diffuse malignant mesothelioma",
          "pleural malignant mesothelioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A malignant neoplasm that arises from mesothelial cells in the pleura and shows a diffuse growth pattern. It arises on the parietal and sometimes visceral pleura as multiple small nodules that later become confluent and invade the chest wall adipose tissue and muscle. Asbestos exposure is the main cause for the development of pleural malignant mesothelioma. It usually affects patients over sixty years of age. The latency period is long. Patients usually present with pleural effusion, dyspnea and chest wall pain. Additional signs and symptoms include chills, sweating, weight loss, and weakness. Morphologic variants include epithelioid, desmoplastic, sarcomatoid, and biphasic mesothelioma. The clinical course is usually aggressive."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005112"
    },
    {
      "id": 7243,
      "label": "malignant epithelioid mesothelioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7834
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4489",
          "EFO:0006452",
          "GARD:0024208",
          "ICDO:9052/3",
          "MEDGEN:163578",
          "NCIT:C7985",
          "UMLS:C0862312"
        ],
        "synonyms": [
          "epithelial mesothelioma",
          "epithelioid mesothelioma",
          "epithelioid mesothelioma, malignant",
          "epithelioid mesothelioma, malignant (morphologic abnormality)",
          "malignant epithelial mesothelioma"
        ],
        "definition": "A malignant neoplasm arising from mesothelial cells in the pleura. It is characterized by the presence of neoplastic cells with an epithelioid appearance. In the majority of cases, the neoplastic epithelioid cells lack significant cytologic atypia; mitotic figures are infrequently seen. In a minority of cases, the neoplastic cells are poorly differentiated and there is evidence of nuclear atypia and increased mitotic activity."
      },
      "child_count": 1,
      "reference_id": "MONDO:0005599"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6838,
      "label": "malignant pleural mesothelioma"
    },
    {
      "id": 7243,
      "label": "malignant epithelioid mesothelioma"
    }
  ]
}