{
  "id": 7925,
  "label": "sarcomatoid carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006406",
  "properties": {
    "xrefs": [
      "DOID:4015",
      "EFO:1000520",
      "ICDO:8032/3",
      "ICDO:8033/3",
      "MEDGEN:60009",
      "NCIT:C27004",
      "UMLS:C0205697"
    ],
    "synonyms": [
      "carcinoma, spindle cell, malignant",
      "pseudosarcomatous carcinoma",
      "sarcomatoid carcinoma",
      "spindle cell carcinoma",
      "spindle cell carcinoma (morphologic abnormality)"
    ],
    "definition": "A malignant epithelial neoplasm characterized by the presence of spindle cells and anaplastic morphologic features. Giant cells and a sarcomatous component may also be present."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    },
    {
      "id": 20048,
      "label": "anaplastic cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:231373",
          "NCIT:C36025",
          "UMLS:C1332287"
        ],
        "synonyms": [
          "anaplastic malignant neoplasm"
        ]
      },
      "child_count": 8,
      "reference_id": "MONDO:0020633"
    },
    {
      "id": 20076,
      "label": "malignant spindle cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20077
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:90746",
          "NCIT:C27091",
          "UMLS:C0334230"
        ],
        "synonyms": [
          "malignant spindle cell neoplasm",
          "malignant spindle cell tumor",
          "malignant spindle cell tumour",
          "spindle cell cancer"
        ],
        "definition": "A malignant neoplasm characterized by the presence of atypical spindle cells."
      },
      "child_count": 8,
      "reference_id": "MONDO:0020663"
    }
  ],
  "children": [
    {
      "id": 4854,
      "label": "sarcomatoid transitional cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7925,
        7972
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4014",
          "GARD:0023263",
          "ICDO:8122/3",
          "MEDGEN:83120",
          "NCIT:C4120",
          "UMLS:C0334271"
        ],
        "synonyms": [
          "sarcomatoid transitional cell carcinoma",
          "transitional cell carcinoma, sarcomatoid",
          "transitional cell spindle cell carcinoma",
          "transitional spindle cell carcinoma"
        ],
        "definition": "A poorly differentiated transitional cell carcinoma characterized by the presence of malignant cells with spindle cell morphologic features."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002837"
    },
    {
      "id": 4962,
      "label": "sarcomatoid basal cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7027,
        7925
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4303",
          "MEDGEN:275402",
          "NCIT:C38111",
          "UMLS:C1519182"
        ],
        "synonyms": [
          "skin sarcomatoid basal cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0002957"
    },
    {
      "id": 5010,
      "label": "sarcomatoid renal cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7199,
        7925
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4473",
          "GARD:0023327",
          "ICDO:8318/3",
          "MEDGEN:220411",
          "NCIT:C27893",
          "ONCOTREE:SRCC",
          "UMLS:C1266043"
        ],
        "synonyms": [
          "RCC w/ sarcomatoid features",
          "renal cell carcinoma with sarcomatoid features",
          "sarcomatoid renal cell cancer",
          "sarcomatoid renal cell carcinoma",
          "SRCC"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A high grade carcinoma of the kidney. It is not a distinct clinicopathological entity and includes a diverse group of renal cell carcinomas which have been transformed from a lower to a higher grade."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003012"
    },
    {
      "id": 5472,
      "label": "pleomorphic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7925
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5662",
          "ICDO:8022/3",
          "MEDGEN:87198",
          "NCIT:C4094",
          "UMLS:C0334233",
          "icd11.foundation:1381572140"
        ],
        "synonyms": [
          "pleomorphic carcinoma",
          "pleomorphic carcinoma (morphologic abnormality)"
        ],
        "definition": "A usually aggressive malignant epithelial neoplasm composed of cells with significant cytologic atypia and nuclear pleomorphism."
      },
      "child_count": 1,
      "reference_id": "MONDO:0003573"
    },
    {
      "id": 6018,
      "label": "rectal sarcomatoid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7925,
        23485
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7356",
          "MEDGEN:235533",
          "NCIT:C5556",
          "UMLS:C1335689"
        ],
        "synonyms": [
          "rectal sarcomatoid cancer",
          "rectal sarcomatoid carcinoma",
          "rectal spindle cell carcinoma",
          "rectum sarcomatoid carcinoma",
          "sarcomatoid carcinoma of rectum",
          "sarcomatoid carcinoma of the rectum"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A biphasic rectal carcinoma with a spindle cell, sarcomatoid component."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004196"
    },
    {
      "id": 7822,
      "label": "lung sarcomatoid carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5040,
        7925
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080777",
          "EFO:1000336",
          "ICD9:162.9",
          "MEDGEN:353871",
          "NCIT:C45540",
          "ONCOTREE:SARCL",
          "SCTID:707460002",
          "UMLS:C1708781"
        ],
        "synonyms": [
          "lung sarcomatoid carcinoma",
          "sarcomatoid carcinoma of the lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A rare, aggressive, poorly differentiated, non-small cell lung carcinoma characterized by the presence of a sarcomatoid component often associated with giant cell differentiation. There is a male to female ratio of 4:1. Clinical symptoms include cough, hemoptysis, chest pain, progressive dyspnea and fever secondary to recurrent pneumonia. Cigarette smoking is a major risk factor."
      },
      "child_count": 6,
      "reference_id": "MONDO:0006279"
    },
    {
      "id": 7957,
      "label": "thymic sarcomatoid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7925,
        7956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8138",
          "EFO:1000577",
          "GARD:0024415",
          "MEDGEN:234772",
          "NCIT:C6463",
          "UMLS:C1335924"
        ],
        "synonyms": [
          "Thymus sarcomatoid carcinoma",
          "sarcomatoid carcinoma of Thymus",
          "sarcomatoid carcinoma of the Thymus",
          "thymic carcinosarcoma",
          "thymic sarcomatoid carcinoma",
          "thymic spindle cell carcinoma",
          "thymus sarcomatoid carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare, usually aggressive, primary thymic carcinoma, characterized by the presence of tumor cells morphologically resembling soft tissue sarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006452"
    },
    {
      "id": 20715,
      "label": "sarcomatoid squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        7925
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:199.1",
          "ICDO:8074/3",
          "NCIT:C27084",
          "SCTID:403900000"
        ],
        "synonyms": [
          "epidermoid spindle cell carcinoma",
          "sarcomatoid squamous cell carcinoma",
          "spindle cell (sarcomatoid) squamous cell carcinoma",
          "squamous cell carcinoma, sarcomatoid",
          "squamous cell carcinoma, spindle cell",
          "squamous cell spindle cell carcinoma"
        ],
        "definition": "A poorly differentiated squamous cell carcinoma characterized by the presence of malignant cells with spindle cell features."
      },
      "child_count": 4,
      "reference_id": "MONDO:0021663"
    }
  ],
  "roots": [
    {
      "id": 6734,
      "label": "carcinoma"
    },
    {
      "id": 20048,
      "label": "anaplastic cancer"
    },
    {
      "id": 20076,
      "label": "malignant spindle cell neoplasm"
    }
  ]
}