{
  "id": 7953,
  "label": "testicular embryonal carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006446",
  "properties": {
    "xrefs": [
      "DOID:5680",
      "EFO:1000565",
      "GARD:0024413",
      "MEDGEN:66771",
      "NCIT:C6341",
      "UMLS:C0238448"
    ],
    "synonyms": [
      "embryonal carcinoma of testis",
      "embryonal carcinoma of the testis",
      "embryonal testis carcinoma",
      "testicular embryonal carcinoma",
      "testis embryonal carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A malignant germ cell neoplasm arising from the testis. It is composed of primitive epithelial cells arranged in solid, papillary, and glandular configurations. Most patients present with a testicular mass, which may be associated with pain. More than half of the patients have metastatic disease at diagnosis. The form of treatment following radical orchiectomy is stage dependent."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4887,
      "label": "testicular pure germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11294
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4087",
          "GARD:0023284",
          "MEDGEN:308089",
          "NCIT:C39915",
          "UMLS:C1514608"
        ],
        "synonyms": [
          "testicular Pure germ cell tumor",
          "testicular Pure germ cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A germ cell tumor that arises from the testis and is characterized by the presence of one histologic component. This category includes seminoma, teratoma, embryonal carcinoma, yolk sac tumor, and trophoblastic tumor."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002874"
    },
    {
      "id": 5335,
      "label": "testicular non-seminomatous germ cell cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5424,
        7954
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5345",
          "GARD:0023503",
          "MEDGEN:233162",
          "NCIT:C5027",
          "UMLS:C1334625"
        ],
        "synonyms": [
          "malignant non-seminomatous germ cell cancer of testis",
          "malignant non-seminomatous germ cell cancer of the testis",
          "malignant non-seminomatous germ cell neoplasm of testis",
          "malignant non-seminomatous germ cell neoplasm of the testis",
          "malignant non-seminomatous germ cell tumor of testis",
          "malignant non-seminomatous germ cell tumor of the testis",
          "malignant non-seminomatous germ cell tumour of testis",
          "malignant non-seminomatous germ cell tumour of the testis",
          "malignant testicular non-seminomatous germ cell neoplasm",
          "malignant testicular non-seminomatous germ cell tumor",
          "malignant testicular non-seminomatous germ cell tumour",
          "testicular germ cell tumor non-seminomatous, malignant",
          "testicular germ cell tumour non-seminomatous, malignant",
          "testicular non-seminomatous germ cell cancer",
          "testicular non-seminomatous germ cell tumor, malignant",
          "testicular non-seminomatous malignant germ cell neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A classification of testicular cancers that arise in specialized sex cells called germ cells. Nonseminomas include embryonal carcinoma, teratoma, choriocarcinoma, and yolk sac tumor."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003403"
    },
    {
      "id": 7107,
      "label": "embryonal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5475
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3308",
          "EFO:0004986",
          "GARD:0005140",
          "ICDO:9070/3",
          "MEDGEN:61653",
          "MESH:D018236",
          "NANDO:2200067",
          "NCIT:C3752",
          "ONCOTREE:EMBCA",
          "Orphanet:180226",
          "UMLS:C0206659"
        ],
        "synonyms": [
          "carcinoma, embryonal, malignant",
          "embryonal carcinoma",
          "primary extragonadal embryonal carcinoma"
        ],
        "definition": "A non-seminomatous malignant germ cell tumor characterized by the presence of large germ cells with abundant cytoplasm resembling epithelial cells, geographic necrosis, high mitotic activity, and pseudoglandular and pseudopapillary structures formation. It can arise from the testis, ovary, and extragonadal sites (central nervous system and mediastinum)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005440"
    },
    {
      "id": 7212,
      "label": "embryonal neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:688",
          "EFO:0005784",
          "MEDGEN:45034",
          "NCIT:C3264",
          "ONCOTREE:EMBT",
          "UMLS:C0027654"
        ],
        "synonyms": [
          "embryonal neoplasm",
          "embryonal tumor",
          "embryonal tumour",
          "EMBT",
          "embryonal cancer"
        ],
        "definition": "A usually malignant neoplasm composed of primitive (immature) tissues that resemble fetal tissues. Medulloblastoma, Ependymoblastoma, Pineoblastoma, and Wilms tumor are representative embryonal neoplasms. --2003"
      },
      "child_count": 12,
      "reference_id": "MONDO:0005564"
    }
  ],
  "children": [
    {
      "id": 5667,
      "label": "childhood embryonal testis carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5638,
        6283,
        7953
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6162",
          "GARD:0023672",
          "MEDGEN:272470",
          "NCIT:C6545",
          "UMLS:C1333007"
        ],
        "synonyms": [
          "childhood embryonal carcinoma of testis",
          "childhood embryonal carcinoma of the testis",
          "childhood testicular embryonal carcinoma",
          "paediatric embryonal carcinoma of testis",
          "paediatric embryonal carcinoma of the testis",
          "paediatric testicular embryonal carcinoma",
          "pediatric embryonal carcinoma of testis",
          "pediatric embryonal carcinoma of the testis",
          "pediatric testicular embryonal carcinoma",
          "testicular embryonal carcinoma of childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An embryonal carcinoma that arises from the testis during childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003788"
    },
    {
      "id": 6321,
      "label": "intratubular embryonal carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7953
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8275",
          "GARD:0024047",
          "MEDGEN:1832671",
          "NCIT:C192096",
          "NCIT:C7325",
          "UMLS:C5784893"
        ],
        "synonyms": [
          "intratubular embryonal carcinoma",
          "stage 0 testicular embryonal carcinoma",
          "stage 0 testicular embryonal carcinoma aJCC v6",
          "stage 0 testicular embryonal carcinoma aJCC v6 and v7",
          "stage 0 testicular embryonal carcinoma aJCC v7"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Stage 0 includes: pTis, N0, M0, S0. pTis: Intratubular germ cell neoplasia (carcinoma in situ). N0: regional lymph node metastasis. M0: No distant metastasis. S0: Marker study levels within normal limits. (AJCC 6th and 7th eds.)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004520"
    }
  ],
  "roots": [
    {
      "id": 4887,
      "label": "testicular pure germ cell tumor"
    },
    {
      "id": 5335,
      "label": "testicular non-seminomatous germ cell cancer"
    },
    {
      "id": 7107,
      "label": "embryonal carcinoma"
    },
    {
      "id": 7212,
      "label": "embryonal neoplasm"
    }
  ]
}