{
  "id": 7956,
  "label": "thymic carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006451",
  "properties": {
    "xrefs": [
      "DOID:3284",
      "DOID:4554",
      "EFO:1000576",
      "GARD:0019695",
      "ICDO:8586/3",
      "MEDGEN:60049",
      "MedDRA:10061031",
      "NANDO:2200079",
      "NCIT:C7569",
      "NCIT:C7612",
      "ONCOTREE:THYC",
      "Orphanet:99868",
      "SCTID:444374006",
      "UMLS:C0205969",
      "icd11.foundation:1351671383"
    ],
    "synonyms": [
      "carcinoma of thymus",
      "malignant thymoma",
      "thymic carcinoma",
      "thymic carcinoma (excluding well differentiated thymic carcinoma)",
      "thymic carcinoma excluding well differentiated thymic carcinoma",
      "thymoma type C",
      "thymoma, malignant",
      "thymoma, malignant (morphologic abnormality)",
      "thymoma, type C (morphologic abnormality)",
      "thymus carcinoma",
      "type C thymoma",
      "THYC"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Thymic carcinoma (TC) is a type of thymic epithelial neoplasm characterized by a high malignant potential."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 4646,
      "label": "thymus cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        6916,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3277",
          "GARD:0023177",
          "ICD10CM:C37",
          "ICD9:164.0",
          "MEDGEN:155883",
          "NCIT:C4962",
          "SCTID:363434003",
          "UMLS:C0751552",
          "icd11.foundation:1718833206"
        ],
        "synonyms": [
          "thymic neoplasm",
          "thymic tumor",
          "thymic tumour",
          "Thymus cancer",
          "cancer of Thymus",
          "cancer of the Thymus",
          "cancer of thymus",
          "malignant Thymus neoplasm",
          "malignant Thymus tumor",
          "malignant Thymus tumour",
          "malignant neoplasm of Thymus",
          "malignant neoplasm of the Thymus",
          "malignant neoplasm of thymus",
          "malignant thymus neoplasm",
          "malignant tumor of Thymus",
          "malignant tumor of the Thymus",
          "malignant tumour of Thymus",
          "malignant tumour of the Thymus",
          "thymus cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the thymus. This category includes malignant thymomas, thymic lymphomas, primary thymic carcinomas, and metastatic carcinomas from other anatomic sites."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002586"
    },
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    },
    {
      "id": 18240,
      "label": "thymic epithelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6916,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005201",
          "MEDGEN:220416",
          "MESH:C536905",
          "NCIT:C6450",
          "ONCOTREE:TET",
          "Orphanet:3398",
          "UMLS:C1266101"
        ],
        "synonyms": [
          "TEN",
          "Thymus epithelial neoplasm",
          "Thymus epithelial tumor",
          "Thymus epithelial tumour",
          "epithelial neoplasm of Thymus",
          "epithelial neoplasm of the Thymus",
          "epithelial tumor of Thymus",
          "epithelial tumor of the Thymus",
          "epithelial tumour of Thymus",
          "epithelial tumour of the Thymus",
          "thymic epithelial tumor",
          "thymic epithelial tumour",
          "thymic epithelium neoplasm",
          "thymus epithelial neoplasm",
          "Tet",
          "thymoma, adult"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An epithelial neoplasm that affects the thymus gland. This category includes thymomas and carcinomas."
      },
      "child_count": 4,
      "reference_id": "MONDO:0018079"
    }
  ],
  "children": [
    {
      "id": 4650,
      "label": "invasive malignant thymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7956,
        7959,
        23004
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3283",
          "GARD:0023180",
          "MEDGEN:78892",
          "NCIT:C7904",
          "UMLS:C0278846"
        ],
        "synonyms": [
          "invasive malignant thymoma",
          "malignant thymoma, invasive",
          "thymoma malignant invasive"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant thymoma that extends beyond the capsule and infiltrates the surrounding tissues."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002592"
    },
    {
      "id": 5165,
      "label": "thymus gland adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        7956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4923",
          "GARD:0023411",
          "MEDGEN:234426",
          "NCIT:C6459",
          "UMLS:C1336743"
        ],
        "synonyms": [
          "Thymus adenocarcinoma",
          "adenocarcinoma of Thymus",
          "adenocarcinoma of the Thymus",
          "thymic adenocarcinoma",
          "thymus adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare primary thymic carcinoma, characterized by the presence of carcinoma cells with glandular differentiation."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003209"
    },
    {
      "id": 5409,
      "label": "thymus squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        7956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5530",
          "EFO:1000579",
          "GARD:0023528",
          "MEDGEN:234814",
          "NCIT:C6455",
          "UMLS:C1336082"
        ],
        "synonyms": [
          "Thymus squamous cell carcinoma",
          "epidermoid thymic carcinoma",
          "squamous cell carcinoma of Thymus",
          "squamous cell carcinoma of the Thymus",
          "thymic squamous cell carcinoma",
          "thymus squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare primary thymic carcinoma, characterized by the presence of keratinizing or non-keratinizing malignant squamous cells. Approximately 10-20% of cases occur in combination with thymoma. The prognosis depends on the tumor stage and the degree of cellular differentiation."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003493"
    },
    {
      "id": 5832,
      "label": "malignant type AB thymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7956,
        17387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6723",
          "GARD:0023758",
          "ICDO:8582/3",
          "MEDGEN:224760",
          "NCIT:C6886",
          "UMLS:C1266093"
        ],
        "synonyms": [
          "malignant thymoma type AB",
          "malignant type AB thymoma",
          "thymoma type AB, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A type AB thymoma which is characterized by an aggressive clinical course (capsular invasion, infiltration of the surrounding tissues) and can metastasize."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003976"
    },
    {
      "id": 6114,
      "label": "lymphoepithelioma-like thymic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5471,
        7956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7599",
          "GARD:0023919",
          "MEDGEN:79026",
          "NCIT:C7998",
          "UMLS:C0279706"
        ],
        "synonyms": [
          "lymphoepithelial Thymus cancer",
          "lymphoepithelial cancer of Thymus",
          "lymphoepithelial cancer of the Thymus",
          "lymphoepithelioma-like Thymus carcinoma",
          "lymphoepithelioma-like carcinoma of Thymus",
          "lymphoepithelioma-like carcinoma of the Thymus",
          "lymphoepithelioma-like thymic carcinoma",
          "malignant lymphoepithelial thymoma",
          "thymic lymphoepithelioma-like carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare, usually aggressive primary thymic carcinoma, characterized by a syncytial growth of undifferentiated carcinoma cells and the presence of a lymphoplasmacytic infiltrate. More than 40% of cases are associated with Epstein-Barr virus infection."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004297"
    },
    {
      "id": 6280,
      "label": "thymus clear cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8137",
          "GARD:0024024",
          "MEDGEN:272488",
          "NCIT:C6462",
          "UMLS:C1333069"
        ],
        "synonyms": [
          "Thymus clear cell carcinoma",
          "clear cell carcinoma of Thymus",
          "clear cell carcinoma of the Thymus",
          "thymic clear cell carcinoma",
          "thymus clear cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare, usually aggressive, primary thymic carcinoma, characterized by the presence of carcinoma cells with clear cytoplasm."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004475"
    },
    {
      "id": 7957,
      "label": "thymic sarcomatoid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7925,
        7956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8138",
          "EFO:1000577",
          "GARD:0024415",
          "MEDGEN:234772",
          "NCIT:C6463",
          "UMLS:C1335924"
        ],
        "synonyms": [
          "Thymus sarcomatoid carcinoma",
          "sarcomatoid carcinoma of Thymus",
          "sarcomatoid carcinoma of the Thymus",
          "thymic carcinosarcoma",
          "thymic sarcomatoid carcinoma",
          "thymic spindle cell carcinoma",
          "thymus sarcomatoid carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare, usually aggressive, primary thymic carcinoma, characterized by the presence of tumor cells morphologically resembling soft tissue sarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006452"
    },
    {
      "id": 7958,
      "label": "thymic undifferentiated carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7257,
        7956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000580",
          "GARD:0024416",
          "MEDGEN:1864846",
          "NCIT:C35718",
          "UMLS:C2188088"
        ],
        "synonyms": [
          "thymic undifferentiated carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare primary thymic carcinoma, characterized by an undifferentiated solid tumor growth, without associated sarcomatoid features."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006455"
    },
    {
      "id": 19965,
      "label": "thymic neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        7956,
        19679
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019696",
          "MEDGEN:900590",
          "NCIT:C171031",
          "Orphanet:99869",
          "SCTID:716653001",
          "UMLS:C2210965",
          "icd11.foundation:381956131"
        ],
        "synonyms": [
          "neuroendocrine carcinoma of thymus",
          "thymic neuroendocrine carcinoma",
          "thymus neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Thymic neuroendocrine carcinoma is a type of thymic epithelial neoplasm displaying evidence of neuroendocrine differentiation."
      },
      "child_count": 15,
      "reference_id": "MONDO:0020516"
    }
  ],
  "roots": [
    {
      "id": 4646,
      "label": "thymus cancer"
    },
    {
      "id": 6734,
      "label": "carcinoma"
    },
    {
      "id": 18240,
      "label": "thymic epithelial neoplasm"
    }
  ]
}