{
  "id": 7959,
  "label": "thymoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006456",
  "properties": {
    "xrefs": [
      "DOID:3275",
      "EFO:1000581",
      "GARD:0016922",
      "HP:0100522",
      "ICD9:239.89",
      "ICDO:8580/1",
      "MEDGEN:52743",
      "MESH:D013945",
      "MedDRA:10043670",
      "NCIT:C3411",
      "ONCOTREE:THYM",
      "Orphanet:99867",
      "SCTID:444231005",
      "UMLS:C0040100",
      "icd11.foundation:33869057"
    ],
    "synonyms": [
      "primary thymic epithelial neoplasm",
      "primary thymic epithelial tumor",
      "primary thymic epithelial tumour",
      "thymoma",
      "thymoma (disease)",
      "THYM"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A neoplasm arising from the epithelial cells of the thymus. Although thymomas are usually encapsulated tumors, they may invade the capsule and infiltrate the surrounding tissues or even metastasize to distant anatomic sites. The following morphologic subtypes are currently recognized: type A, type B, type AB, metaplastic, micronodular, microscopic, and sclerosing thymoma. Thymomas type B are further subdivided into types B1, B2, and B3. Thymoma type B3 usually has the most aggressive clinical course."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 18240,
      "label": "thymic epithelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6916,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005201",
          "MEDGEN:220416",
          "MESH:C536905",
          "NCIT:C6450",
          "ONCOTREE:TET",
          "Orphanet:3398",
          "UMLS:C1266101"
        ],
        "synonyms": [
          "TEN",
          "Thymus epithelial neoplasm",
          "Thymus epithelial tumor",
          "Thymus epithelial tumour",
          "epithelial neoplasm of Thymus",
          "epithelial neoplasm of the Thymus",
          "epithelial tumor of Thymus",
          "epithelial tumor of the Thymus",
          "epithelial tumour of Thymus",
          "epithelial tumour of the Thymus",
          "thymic epithelial tumor",
          "thymic epithelial tumour",
          "thymic epithelium neoplasm",
          "thymus epithelial neoplasm",
          "Tet",
          "thymoma, adult"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An epithelial neoplasm that affects the thymus gland. This category includes thymomas and carcinomas."
      },
      "child_count": 4,
      "reference_id": "MONDO:0018079"
    }
  ],
  "children": [
    {
      "id": 4647,
      "label": "encapsulated thymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7959
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3278",
          "GARD:0023178",
          "MEDGEN:232452",
          "NCIT:C7386",
          "UMLS:C1333383"
        ],
        "synonyms": [
          "encapsulated thymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A thymoma that is confined within the capsule and may display benign or malignant morphologic characteristics."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002587"
    },
    {
      "id": 4648,
      "label": "thymoma type A",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7959
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3279",
          "GARD:0020892",
          "ICDO:8581/1",
          "MEDGEN:266099",
          "NCIT:C6454",
          "Orphanet:263310",
          "UMLS:C1266091"
        ],
        "synonyms": [
          "medullary thymoma",
          "primary thymic epithelial neoplasm type A",
          "primary thymic epithelial tumor type A",
          "primary thymic epithelial tumour type A",
          "spindle cell thymoma",
          "thymoma type A"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A thymic epithelial neoplasm characterized by the presence of spindle and/or oval neoplastic epithelial cells. Lymphocytic infiltration is minimal or absent. It may be associated with myasthenia gravis or pure red cell aplasia. The majority of cases occur in the anterior mediastinum as Masaoka stage I tumors. Approximately 20% of the cases occur as stage II or stage III tumors. Type A thymoma generally behaves as a benign tumor and the overall survival is reported to be 100% at 5 and 10 years."
      },
      "child_count": 1,
      "reference_id": "MONDO:0002588"
    },
    {
      "id": 4649,
      "label": "combined thymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7959
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3281",
          "GARD:0023179",
          "MEDGEN:317530",
          "NCIT:C45722",
          "UMLS:C1707449"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0002590"
    },
    {
      "id": 4650,
      "label": "invasive malignant thymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7956,
        7959,
        23004
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3283",
          "GARD:0023180",
          "MEDGEN:78892",
          "NCIT:C7904",
          "UMLS:C0278846"
        ],
        "synonyms": [
          "invasive malignant thymoma",
          "malignant thymoma, invasive",
          "thymoma malignant invasive"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant thymoma that extends beyond the capsule and infiltrates the surrounding tissues."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002592"
    },
    {
      "id": 5974,
      "label": "noninvasive malignant thymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7959
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7214",
          "GARD:0023848",
          "MEDGEN:78893",
          "NCIT:C9080",
          "UMLS:C0278847"
        ],
        "synonyms": [
          "malignant thymoma, noninvasive",
          "thymoma malignant noninvasive"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A morphologically malignant thymoma that is entirely confined within the capsule."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004147"
    },
    {
      "id": 11310,
      "label": "thymoma, familial",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        7959
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024710",
          "MEDGEN:376447",
          "MESH:C564767",
          "OMIM:274230",
          "UMLS:C1848814"
        ],
        "synonyms": [
          "hereditary thymoma (disease)",
          "thymoma, familial",
          "thymic neoplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An instance of thymoma (disease) that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010127"
    },
    {
      "id": 17386,
      "label": "thymoma type B",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6569,
        7959
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3282",
          "GARD:0020893",
          "MEDGEN:231253",
          "NCIT:C7114",
          "Orphanet:263317",
          "UMLS:C1328042"
        ],
        "synonyms": [
          "Dendritic cell thymoma",
          "dendritic cell thymoma",
          "dendritic cell thymoma (disease)",
          "epithelioid thymoma",
          "plump cell thymoma",
          "primary thymic epithelial neoplasm type B",
          "primary thymic epithelial tumor type B",
          "primary thymic epithelial tumour type B",
          "thymoma type B"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An epithelial neoplasm arising from the thymus. It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. It includes thymoma type B1 which is a thymoma of low grade malignant potential, thymoma type B2 which is a thymoma of moderate malignancy, and thymoma type B3 which is also known as well differentiated thymic carcinoma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0016974"
    },
    {
      "id": 17387,
      "label": "thymoma type AB",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7959
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3280",
          "EFO:1000582",
          "GARD:0020894",
          "ICDO:8582/1",
          "MEDGEN:220414",
          "NCIT:C6885",
          "Orphanet:263324",
          "UMLS:C1266092"
        ],
        "synonyms": [
          "mixed type thymoma",
          "primary thymic epithelial neoplasm type AB",
          "primary thymic epithelial tumor type AB",
          "primary thymic epithelial tumour type AB",
          "thymoma type AB"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A thymic epithelial neoplasm characterized by the presence of a lymphocyte-poor component similar to that seen in type A thymoma and a lymphocyte-rich component which contains neoplastic small polygonal epithelial cells. It may be associated with myasthenia gravis and pure red cell aplasia. The majority of cases occur in the anterior mediastinum as Masaoka stage I tumors. A minority of the cases occur as stage II or stage III tumors. The overall survival is reported to be 80-100% at 5 and 10 years."
      },
      "child_count": 1,
      "reference_id": "MONDO:0016975"
    }
  ],
  "roots": [
    {
      "id": 18240,
      "label": "thymic epithelial neoplasm"
    }
  ]
}