{
  "id": 7968,
  "label": "thyroid gland undifferentiated (anaplastic) carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006468",
  "properties": {
    "xrefs": [
      "DOID:0080522",
      "EFO:1000595",
      "GARD:0000664",
      "HP:0011779",
      "MEDGEN:116064",
      "MESH:D065646",
      "MedDRA:10002240",
      "NCIT:C3878",
      "ONCOTREE:THAP",
      "Orphanet:142",
      "SCTID:255031003",
      "UMLS:C0238461",
      "icd11.foundation:320540024"
    ],
    "synonyms": [
      "Dedifferentiated thyroid gland carcinoma",
      "anaplastic carcinoma of the thyroid",
      "anaplastic carcinoma of the thyroid gland",
      "anaplastic carcinoma of thyroid",
      "anaplastic carcinoma of thyroid gland",
      "anaplastic thyroid cancer",
      "anaplastic thyroid carcinoma",
      "anaplastic thyroid gland carcinoma",
      "metaplastic thyroid gland carcinoma",
      "pleomorphic thyroid gland carcinoma",
      "sarcomatoid thyroid gland carcinoma",
      "thyroid gland carcinosarcoma",
      "thyroid gland undifferentiated (anaplastic) carcinoma",
      "thyroid gland undifferentiated carcinoma",
      "undifferentiated (anaplastic) thyroid gland cancer",
      "undifferentiated (anaplastic) thyroid gland carcinoma",
      "undifferentiated carcinoma of the thyroid",
      "undifferentiated carcinoma of the thyroid gland",
      "undifferentiated carcinoma of thyroid",
      "undifferentiated carcinoma of thyroid gland",
      "undifferentiated thyroid carcinoma",
      "undifferentiated thyroid gland carcinoma",
      "undifferentiated thyroid tumor",
      "undifferentiated thyroid tumour",
      "THAP",
      "thyroid cancer, anaplastic",
      "thyroid carcinoma, anaplastic"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A primary carcinoma of the thyroid gland composed of undifferentiated cells. The malignant cells demonstrate evidence of epithelial differentiation, either by immunohistochemistry or electron microscopic studies. Microscopically, in the majority of cases there is a mixture of spindle, epithelioid, and giant cells. The vast majority of the patients present with a rapidly enlarging neck mass. The clinical course is usually aggressive."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6943,
      "label": "large cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4552",
          "ICDO:8012/3",
          "MEDGEN:61665",
          "MESH:D018287",
          "NCIT:C3780",
          "UMLS:C0206704"
        ],
        "synonyms": [
          "carcinoma, large cell",
          "large cell carcinoma"
        ],
        "definition": "A malignant epithelial neoplasm composed of large, atypical cells."
      },
      "child_count": 5,
      "reference_id": "MONDO:0005232"
    },
    {
      "id": 7257,
      "label": "undifferentiated carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006772",
          "ICDO:8020/3",
          "ICDO:8021/3",
          "MEDGEN:60010",
          "NCIT:C3692",
          "UMLS:C0205698"
        ],
        "synonyms": [
          "anaplastic carcinoma",
          "carcinoma, undifferentiated",
          "carcinoma, undifferentiated, malignant",
          "undifferentiated carcinoma"
        ],
        "definition": "A usually aggressive malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular, squamous, or transitional cell differentiation."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005617"
    },
    {
      "id": 16049,
      "label": "thyroid gland carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4245,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3963",
          "EFO:0002892",
          "GARD:0019763",
          "HP:0002890",
          "MEDGEN:107811",
          "MedDRA:10007476",
          "NANDO:2200074",
          "NCIT:C4815",
          "Orphanet:100088",
          "SCTID:448216007",
          "UMLS:C0549473"
        ],
        "synonyms": [
          "cancer of the thyroid",
          "cancer of thyroid",
          "head and neck cancer, thyroid",
          "thyroid cancer",
          "thyroid gland cancer",
          "carcinoma of the thyroid",
          "carcinoma of the thyroid gland",
          "carcinoma of thyroid",
          "carcinoma of thyroid gland",
          "thyroid carcinoma",
          "thyroid gland carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic."
      },
      "child_count": 22,
      "reference_id": "MONDO:0015075"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6943,
      "label": "large cell carcinoma"
    },
    {
      "id": 7257,
      "label": "undifferentiated carcinoma"
    },
    {
      "id": 16049,
      "label": "thyroid gland carcinoma"
    }
  ]
}