{
  "id": 7972,
  "label": "transitional cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006474",
  "properties": {
    "xrefs": [
      "DOID:2671",
      "EFO:1000601",
      "GARD:0007794",
      "ICDO:8120/3",
      "MEDGEN:2875",
      "MESH:D002295",
      "NCIT:C2930",
      "UMLS:C0007138"
    ],
    "synonyms": [
      "transitional cell neoplasm",
      "transitional cell tumor",
      "transitional cell tumour",
      "carcinoma of transitional epithelial cell",
      "carcinoma of urothelial cell",
      "carcinoma, urothelial, malignant",
      "transitional carcinoma",
      "transitional cell carcinoma",
      "transitional epithelial cell carcinoma",
      "urothelial cell carcinoma"
    ],
    "definition": "A malignant neoplasm arising from the transitional epithelium, usually affecting the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary configuration. It is graded 1 to 3 or 4 according to the degree of cellular differentiation and architectural patterns. Grade 1 transitional cell carcinoma is histologically benign but it may recur. Transitional cell carcinomas may also affect the upper respiratory tract and the ovaries."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    }
  ],
  "children": [
    {
      "id": 4847,
      "label": "Bartholin gland transitional cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4848,
        7972
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3998",
          "GARD:0023256",
          "MEDGEN:267340",
          "NCIT:C40297",
          "UMLS:C1511053"
        ],
        "synonyms": [
          "Bartholin gland transitional cell carcinoma",
          "Bartholin's gland transitional cell carcinoma",
          "major vestibular gland transitional cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare carcinoma that arises from the Bartholin gland and is characterized by the presence of malignant urothelial-type epithelial cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002828"
    },
    {
      "id": 4850,
      "label": "endometrial transitional cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4530,
        7972
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4005",
          "GARD:0023259",
          "MEDGEN:273232",
          "NCIT:C40154",
          "UMLS:C1516864"
        ],
        "synonyms": [
          "endometrial transitional cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare primary carcinoma of the endometrium characterized by the presence of malignant epithelial cells resembling urothelial transitional cells. The malignant transitional cells constitute at least 90% of the tumor cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002832"
    },
    {
      "id": 4851,
      "label": "fallopian tube transitional cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7759,
        7972
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4008",
          "GARD:0023260",
          "MEDGEN:274492",
          "NCIT:C40104",
          "UMLS:C1517128"
        ],
        "synonyms": [
          "fallopian tube transitional cell cancer",
          "fallopian tube transitional cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare transitional cell carcinoma that arises from the fallopian tube."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002833"
    },
    {
      "id": 4852,
      "label": "primary prostate urothelial carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6882,
        7972
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4011",
          "GARD:0023261",
          "MEDGEN:271382",
          "NCIT:C39898",
          "UMLS:C1514430"
        ],
        "synonyms": [
          "primary prostate urothelial cancer",
          "primary prostate urothelial carcinoma",
          "prostate gland transitional cell carcinoma",
          "prostate transitional cell carcinoma",
          "prostate urothelial carcinoma",
          "transitional cell carcinoma of prostate",
          "transitional cell carcinoma of the prostate"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An urothelial carcinoma that arises from the urothelial lining of the prostatic ducts or the prostatic urethra."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002834"
    },
    {
      "id": 4854,
      "label": "sarcomatoid transitional cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7925,
        7972
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4014",
          "GARD:0023263",
          "ICDO:8122/3",
          "MEDGEN:83120",
          "NCIT:C4120",
          "UMLS:C0334271"
        ],
        "synonyms": [
          "sarcomatoid transitional cell carcinoma",
          "transitional cell carcinoma, sarcomatoid",
          "transitional cell spindle cell carcinoma",
          "transitional spindle cell carcinoma"
        ],
        "definition": "A poorly differentiated transitional cell carcinoma characterized by the presence of malignant cells with spindle cell morphologic features."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002837"
    },
    {
      "id": 7869,
      "label": "ovarian transitional cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6864,
        7972
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4000",
          "EFO:1000435",
          "GARD:0024373",
          "MEDGEN:233811",
          "NCIT:C5240",
          "UMLS:C1335184"
        ],
        "synonyms": [
          "ovarian transitional cell cancer",
          "ovarian transitional cell carcinoma",
          "ovary transitional cell carcinoma",
          "transitional cell carcinoma of ovary",
          "transitional cell carcinoma of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the ovary and is characterized by the presence of malignant epithelial cells that resemble malignant urothelial cells. There is no morphologic evidence of a benign or borderline Brenner tumor component present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006343"
    },
    {
      "id": 7876,
      "label": "papillary transitional cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7972,
        8000
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4012",
          "EFO:1000450",
          "GARD:0024378",
          "ICDO:8130/3",
          "MEDGEN:137736",
          "NCIT:C4122",
          "UMLS:C0334274"
        ],
        "synonyms": [
          "papillary transitional carcinoma",
          "papillary transitional cell carcinoma (morphologic abnormality)"
        ],
        "definition": "A non-invasive or invasive transitional cell carcinoma characterized by a papillary growth pattern. It may occur in the bladder or the renal pelvis."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006350"
    },
    {
      "id": 16835,
      "label": "transitional cell carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6929,
        7594,
        7972
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020484",
          "MEDGEN:1676303",
          "Orphanet:213746",
          "UMLS:C5191668"
        ],
        "synonyms": [
          "body of uterus transitional cell carcinoma",
          "endometrial transitional cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A transitional cell carcinoma that involves the body of uterus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016272"
    },
    {
      "id": 23006,
      "label": "urothelial carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7836,
        7972,
        21366
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0008528",
          "GARD:0025829",
          "MEDGEN:760495",
          "NCIT:C4030",
          "UMLS:C2145472"
        ],
        "synonyms": [
          "Uroepithelial carcinoma",
          "transitional cell car. -uroth.",
          "transitional cell carcinoma of the urinary tract",
          "transitional cell carcinoma of the urothelial tract",
          "urothelial carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A malignant neoplasm derived from the transitional epithelium of the urinary tract (urinary bladder, ureter, urethra, or renal pelvis). It is frequently papillary."
      },
      "child_count": 15,
      "reference_id": "MONDO:0040679"
    }
  ],
  "roots": [
    {
      "id": 6734,
      "label": "carcinoma"
    }
  ]
}