{
  "id": 7974,
  "label": "undifferentiated ovarian carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006477",
  "properties": {
    "xrefs": [
      "EFO:1000605",
      "GARD:0024428",
      "MEDGEN:83410",
      "NCIT:C4509",
      "SCTID:254856004",
      "UMLS:C0346167"
    ],
    "synonyms": [
      "anaplastic carcinoma of ovary",
      "anaplastic carcinoma of the ovary",
      "anaplastic ovarian carcinoma",
      "ovarian undifferentiated carcinoma",
      "ovary undifferentiated carcinoma",
      "undifferentiated carcinoma of ovary",
      "undifferentiated carcinoma of the ovary",
      "undifferentiated ovarian cancer",
      "undifferentiated ovarian carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An aggressive carcinoma arising from the ovary. Most patients present with advanced disease. Microscopically, it is characterized by significant cytologic atypia, increased mitotic activity, and necrosis. The prognosis is usually poor."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6864,
      "label": "ovarian carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4001",
          "EFO:0001075",
          "GARD:0024154",
          "MEDGEN:1648335",
          "NCIT:C4908",
          "UMLS:C4721610"
        ],
        "synonyms": [
          "ovarian cancer",
          "ovarian epithelial cancer",
          "carcinoma of ovary",
          "carcinoma of the ovary",
          "epithelial ovarian cancer",
          "ovarian carcinoma",
          "ovary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm originating from the surface ovarian epithelium. It accounts for the greatest number of deaths from malignancies of the female genital tract and is the fifth leading cause of cancer fatalities in women. It is predominantly a disease of older white women of northern European extraction, but it is seen in all ages and ethnic groups. Adenocarcinomas constitute the vast majority of ovarian carcinomas. The pattern of metastatic spread in ovarian carcinoma is similar regardless of the microscopic type. The most common sites of involvement are the contralateral ovary, peritoneal cavity, para-aortic and pelvic lymph nodes, and liver. Lung and pleura are the most common sites of extra-abdominal spread. The primary form of therapy is surgical. The overall prognosis of ovarian carcinoma remains poor, a direct result of its rapid growth rate and the lack of early symptoms. --2002"
      },
      "child_count": 9,
      "reference_id": "MONDO:0005140"
    },
    {
      "id": 7257,
      "label": "undifferentiated carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006772",
          "ICDO:8020/3",
          "ICDO:8021/3",
          "MEDGEN:60010",
          "NCIT:C3692",
          "UMLS:C0205698"
        ],
        "synonyms": [
          "anaplastic carcinoma",
          "carcinoma, undifferentiated",
          "carcinoma, undifferentiated, malignant",
          "undifferentiated carcinoma"
        ],
        "definition": "A usually aggressive malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular, squamous, or transitional cell differentiation."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005617"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6864,
      "label": "ovarian carcinoma"
    },
    {
      "id": 7257,
      "label": "undifferentiated carcinoma"
    }
  ]
}