{
  "id": 7975,
  "label": "undifferentiated pancreatic carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006478",
  "properties": {
    "xrefs": [
      "EFO:1000606",
      "GARD:0027757",
      "MEDGEN:237030",
      "NCIT:C5722",
      "ONCOTREE:UCP",
      "UMLS:C1336861"
    ],
    "synonyms": [
      "pancreas undifferentiated carcinoma",
      "pancreatic carcinosarcoma",
      "pleomorphic large cell pancreatic carcinoma",
      "sarcomatoid pancreatic carcinoma",
      "spindle cell pancreatic carcinoma",
      "undifferentiated (anaplastic) pancreatic carcinoma",
      "undifferentiated carcinoma of pancreas",
      "undifferentiated carcinoma of the pancreas",
      "undifferentiated pancreatic carcinoma",
      "UCP"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma with poor prognosis that arises from the pancreas. It is characterized by the presence of a significant malignant component that does not show differentiation. The malignant cells represent a mixture of large, pleomorphic cells and giant cells, or adenocarcinoma cells and spindle cells, or spindle cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 6905,
      "label": "pancreatic ductal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7247,
        7633
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3498",
          "DOID:3587",
          "EFO:0002517",
          "GARD:0027716",
          "ICD9:157.3",
          "MEDGEN:277490",
          "MESH:D021441",
          "NCIT:C9120",
          "UMLS:C1335302",
          "icd11.foundation:581089833"
        ],
        "synonyms": [
          "ductal adenocarcinoma of pancreas",
          "ductal adenocarcinoma of the pancreas",
          "pancreas ductal adenocarcinoma",
          "pancreas tubular adenocarcinoma",
          "pancreatic duct adenocarcinoma",
          "pancreatic ductal adenocarcinoma",
          "pancreatic ductal carcinoma",
          "pancreatic tubular adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An infiltrating adenocarcinoma that arises from the epithelial cells of the pancreas. It affects males more often than females and the patients are usually over 50 years of age. Microscopically it is characterized by the presence of glandular (ductal) differentiation and desmoplastic stroma formation. Signs and symptoms include pain, loss of weight, and jaundice. It grows rapidly and is usually detected after it has metastasized to other anatomic sites. The prognosis is usually poor."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005184"
    },
    {
      "id": 7257,
      "label": "undifferentiated carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006772",
          "ICDO:8020/3",
          "ICDO:8021/3",
          "MEDGEN:60010",
          "NCIT:C3692",
          "UMLS:C0205698"
        ],
        "synonyms": [
          "anaplastic carcinoma",
          "carcinoma, undifferentiated",
          "carcinoma, undifferentiated, malignant",
          "undifferentiated carcinoma"
        ],
        "definition": "A usually aggressive malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular, squamous, or transitional cell differentiation."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005617"
    }
  ],
  "children": [
    {
      "id": 7976,
      "label": "undifferentiated pancreatic carcinoma with osteoclast-like giant cells",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7975
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7718",
          "EFO:1000607",
          "GARD:0021782",
          "MEDGEN:389157",
          "NCIT:C5723",
          "Orphanet:424080",
          "UMLS:C2007059"
        ],
        "synonyms": [
          "OGCT of pancreas",
          "osteoclast-like giant cell neoplasm of pancreas",
          "osteoclast-like giant cell neoplasm of the pancreas",
          "osteoclastic giant cell tumor of pancreas",
          "osteoclastic giant cell tumour of pancreas",
          "pancreatic osteoclast-like giant cell carcinoma",
          "pancreatic osteoclastic giant cell tumor",
          "pancreatic osteoclastic giant cell tumour",
          "pancreatic undifferentiated carcinoma with osteoclast-like giant cells",
          "undifferentiated carcinoma of pancreas with osteoclast-like giant cells",
          "undifferentiated pancreatic carcinoma with osteoclast-like giant cells"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare variant of undifferentiated pancreatic carcinoma characterized by the presence of non-neoplastic osteoclast-like giant cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006479"
    }
  ],
  "roots": [
    {
      "id": 6905,
      "label": "pancreatic ductal adenocarcinoma"
    },
    {
      "id": 7257,
      "label": "undifferentiated carcinoma"
    }
  ]
}