{
  "id": 7983,
  "label": "uveal melanoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006486",
  "properties": {
    "xrefs": [
      "DOID:6039",
      "EFO:1000616",
      "GARD:0008621",
      "MEDGEN:65077",
      "MESH:C536494",
      "MedDRA:10061252",
      "NCIT:C7712",
      "OMIM:155720",
      "ONCOTREE:UM",
      "Orphanet:39044",
      "UMLS:C0220633"
    ],
    "synonyms": [
      "intraocular melanoma",
      "melanoma (disease) of uvea",
      "melanoma of the uvea",
      "melanoma of uvea",
      "melanoma, uveal, malignant",
      "uvea melanoma",
      "uvea melanoma (disease)",
      "uveal melanoma",
      "iris melanoma",
      "choroidal melanoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "A melanoma derived from melanocytes of the uveal tract. It is the most common primary intraocular tumor in the United States and Western Europe. Similar to melanoma of the skin, it is rare in Africa and Asia. Diagnostic procedures include ophthalmoscopic exam, fluorescein angiography and ultrasound. Treatment includes: surgical excision of the eye, iridocyclectomy and tumor resection. Recent treatments also include radiotherapy or photo coagulation. Classification of uveal melanomas recognizes four cell types within these tumors: epithelioid, intermediate, mixed cell, and spindle cell types. The spindle cell type uveal melanomas are further sub-classified as spindle cell type A and spindle cell type B."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 4710,
      "label": "uveal cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4353,
        20436
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3479",
          "EFO:1001230",
          "MEDGEN:1772018",
          "NCIT:C6105",
          "UMLS:C3665670",
          "icd11.foundation:232747171"
        ],
        "synonyms": [
          "uveal tumor",
          "uveal tumour",
          "cancer of uvea",
          "malignant neoplasm of the uvea",
          "malignant neoplasm of uvea",
          "malignant tumor of the uvea",
          "malignant tumor of uvea",
          "malignant tumour of the uvea",
          "malignant tumour of uvea",
          "malignant uvea neoplasm",
          "malignant uvea tumor",
          "malignant uvea tumour",
          "malignant uveal neoplasm",
          "malignant uveal tumor",
          "malignant uveal tumour",
          "uvea cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm that affects the choroid, ciliary body, or iris."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002659"
    },
    {
      "id": 7858,
      "label": "ocular melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4353,
        6832
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1752",
          "EFO:1000403",
          "GARD:0007236",
          "MEDGEN:107846",
          "NCIT:C8562",
          "ONCOTREE:OM",
          "UMLS:C0558356"
        ],
        "synonyms": [
          "eye melanoma",
          "eye melanoma (disease)",
          "eyeball of camera-type eye melanoma",
          "eyeball of camera-type eye melanoma (disease)",
          "melanoma (disease) of eyeball of camera-type eye",
          "melanoma of eye",
          "melanoma of the eye",
          "ocular melanoma",
          "OM"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A melanoma that arises from the structures of the eye or ocular adnexa."
      },
      "child_count": 12,
      "reference_id": "MONDO:0006325"
    }
  ],
  "children": [
    {
      "id": 5624,
      "label": "spindle cell intraocular melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7943,
        7983,
        20076
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6037",
          "GARD:0023646",
          "MEDGEN:76015",
          "NCIT:C7986",
          "UMLS:C0279687"
        ],
        "synonyms": [
          "spindle cell melanoma of the uvea",
          "spindle cell melanoma of uvea",
          "spindle cell uveal melanoma",
          "uveal spindle cell melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A melanoma arising from the choroid, ciliary body, or the iris. It is characterized by the presence of spindle-shaped melanocytes."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003744"
    },
    {
      "id": 5741,
      "label": "malignant choroid melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7983,
        8163
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6438",
          "GARD:0023710",
          "MEDGEN:138064",
          "NCIT:C4561",
          "SCTID:255021005",
          "UMLS:C0346388"
        ],
        "synonyms": [
          "choroid malignant melanoma",
          "choroid melanoma",
          "choroidal melanoma",
          "malignant melanoma of choroid",
          "malignant melanoma of the choroid",
          "melanoma (disease) of optic choroid",
          "melanoma of choroid",
          "melanoma of the choroid",
          "optic choroid melanoma",
          "optic choroid melanoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A uveal melanoma that arises from the choroid. It is the most common primary malignant intraocular tumor. It usually affects Caucasians of northern European descent. It usually remains asymptomatic for a long period. When signs and symptoms occur, they include blurred vision, visual field loss, floaters, and ocular pain. Tumor size is the most important factor that relates to prognosis."
      },
      "child_count": 10,
      "reference_id": "MONDO:0003878"
    },
    {
      "id": 5772,
      "label": "mixed cell uveal melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6522",
          "EFO:1000380",
          "GARD:0023728",
          "MEDGEN:235330",
          "NCIT:C35781",
          "UMLS:C1334782"
        ],
        "synonyms": [
          "mixed cell uveal melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A melanoma arising from the choroid, ciliary body, or the iris. It is characterized by the presence of a mixture of spindle A melanoma cells, spindle B melanoma cells, and epithelioid melanoma cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003910"
    },
    {
      "id": 5786,
      "label": "posterior uveal melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6566",
          "GARD:0023740"
        ],
        "synonyms": [
          "medium/large size posterior uveal melanoma",
          "small size posterior uveal melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0003927"
    },
    {
      "id": 5902,
      "label": "intermediate cell type uveal melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6992",
          "GARD:0023800",
          "MEDGEN:76016",
          "NCIT:C7989",
          "UMLS:C0279693"
        ],
        "synonyms": [
          "Intermediate cell type intraocular melanoma",
          "Intermediate cell type uveal melanoma",
          "intraocular mixed cell type melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Uveal melanoma characterized by the presence of intermediate cells which are similar to but smaller than epithelioid cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004062"
    },
    {
      "id": 5904,
      "label": "iris melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4709,
        7983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6994",
          "GARD:0023802",
          "MEDGEN:87559",
          "NCIT:C9088",
          "SCTID:255012009",
          "UMLS:C0346373"
        ],
        "synonyms": [
          "iris malignant melanoma",
          "iris melanoma",
          "iris melanoma (disease)",
          "malignant melanoma of iris",
          "malignant melanoma of the iris",
          "melanoma (disease) of iris",
          "melanoma of iris",
          "melanoma of the iris",
          "malignant iris melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A uveal melanoma that arises from the iris. It is the most common primary malignant neoplasm of the iris. The majority arise in preexisting nevi."
      },
      "child_count": 6,
      "reference_id": "MONDO:0004064"
    },
    {
      "id": 6178,
      "label": "necrotic uveal melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7808",
          "GARD:0023959",
          "MEDGEN:1669717",
          "NCIT:C7990",
          "UMLS:C0279695"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A uveal melanoma characterized by the presence of tumor cell necrosis."
      },
      "child_count": 1,
      "reference_id": "MONDO:0004365"
    },
    {
      "id": 7755,
      "label": "epithelioid cell uveal melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4977,
        7983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7040",
          "EFO:1000244",
          "GARD:0024325",
          "MEDGEN:234223",
          "NCIT:C35780",
          "UMLS:C1333422"
        ],
        "synonyms": [
          "epithelioid cell melanoma of uvea",
          "epithelioid cell uveal melanoma",
          "uvea epithelioid cell melanoma",
          "uveal epithelioid cell melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A uveal melanoma characterized by the presence of malignant large epithelioid melanocytes."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006200"
    }
  ],
  "roots": [
    {
      "id": 4710,
      "label": "uveal cancer"
    },
    {
      "id": 7858,
      "label": "ocular melanoma"
    }
  ]
}