{
  "id": 7995,
  "label": "acute respiratory distress syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006502",
  "properties": {
    "xrefs": [
      "EFO:1000637",
      "ICD10CM:J80",
      "MEDGEN:1812214",
      "MedDRA:10001052",
      "NCIT:C3353",
      "UMLS:C2887484",
      "icd11.foundation:1189702844"
    ],
    "synonyms": [
      "ARDS",
      "acute respiratory distress syndrome",
      "shock lung",
      "ALI",
      "Stiff lung",
      "acute lung injury",
      "increased-permeability pulmonary edema",
      "increased-permeability pulmonary oedema",
      "non-cardiogenic pulmonary edema",
      "non-cardiogenic pulmonary oedema"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "Progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. Cases of neonatal respiratory distress syndrome are not included in this definition."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 3448,
      "label": "acute respiratory failure",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20092,
        20352
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:J96.0",
          "ICD9:518.81",
          "MEDGEN:75540",
          "NCIT:C27043",
          "SCTID:65710008",
          "UMLS:C0264490",
          "icd11.foundation:875272781"
        ],
        "synonyms": [
          "acute respiratory failure",
          "respiratory failure, acute"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Life-threatening respiratory failure that develops rapidly. Causes include injury, sepsis, drug overdose, and pancreatitis. It manifests with dyspnea and cyanosis and may lead to cardiovascular shock."
      },
      "child_count": 6,
      "reference_id": "MONDO:0001208"
    },
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    }
  ],
  "children": [
    {
      "id": 23879,
      "label": "adult acute respiratory distress syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7995
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11394",
          "GARD:0018902",
          "MEDGEN:20540",
          "MESH:D012128",
          "Orphanet:70578",
          "SCTID:67782005",
          "UMLS:C0035222",
          "icd11.foundation:1466842111"
        ],
        "synonyms": [
          "adult ARDS",
          "adult acute respiratory distress syndrome",
          "adult respiratory distress syndrome",
          "adult respiratory distress syndrome, ARDS",
          "respiratory distress syndrome, adult",
          "ARDS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A very severe form of acute pulmonary failure secondary to capillary permeability impairment. The symptoms include dyspnea, hypotension and multivisceral failure. The disease is characterized by bilateral pulmonary infiltrates and severe hypoxemia due to increased alveolar-capillary permeability. The severity depends on the degree of alveolar epithelial injury, with a mortality rate of 30-50%."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100130"
    },
    {
      "id": 23880,
      "label": "pediatric acute respiratory distress syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7995
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027370",
          "MEDGEN:1876564",
          "Orphanet:685082",
          "UMLS:C6012346"
        ],
        "synonyms": [
          "PARDS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Acute respiratory distress syndromet that occurs in pediatric patients and includes findings of new infiltrates (unilateral or bilateral) consistent with acute parenchymal disease, edema not fully explained by fluid overload or cardiac failure, and may present as new acute lung disease in setting of chronic lung disease and/or heart disease, and perinatal lung disease is excluded."
      },
      "child_count": 1,
      "reference_id": "MONDO:0100131"
    }
  ],
  "roots": [
    {
      "id": 3448,
      "label": "acute respiratory failure"
    },
    {
      "id": 4370,
      "label": "syndromic disease"
    }
  ]
}