{
  "id": 8000,
  "label": "papillary carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006509",
  "properties": {
    "xrefs": [
      "DOID:3113",
      "EFO:1000646",
      "ICDO:8050/3",
      "MEDGEN:40105",
      "MESH:D002291",
      "NCIT:C2927",
      "UMLS:C0007133"
    ],
    "synonyms": [
      "papillary carcinoma",
      "papillary carcinoma (morphologic abnormality)",
      "papillary carcinoma NOS (morphologic abnormality)"
    ],
    "definition": "A malignant epithelial neoplasm characterized by a papillary growth pattern. A papillary carcinoma may be composed of glandular cells (papillary adenocarcinoma), squamous cells (papillary squamous cell carcinoma), or transitional cells (papillary transitional cell carcinoma). Bladder carcinoma is a representative example of papillary transitional cell carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    },
    {
      "id": 20336,
      "label": "papillary epithelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:235456",
          "NCIT:C8429",
          "UMLS:C1335324"
        ],
        "synonyms": [
          "papillary epithelial neoplasm"
        ]
      },
      "child_count": 9,
      "reference_id": "MONDO:0021096"
    }
  ],
  "children": [
    {
      "id": 4583,
      "label": "papillary adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        8000
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3112",
          "ICDO:8260/3",
          "MEDGEN:123",
          "MESH:D000231",
          "NCIT:C2853",
          "UMLS:C0001420"
        ],
        "synonyms": [
          "adenocarcinoma, papillary, malignant",
          "papillary adenocarcinoma",
          "papillary adenocarcinoma (morphologic abnormality)",
          "papillary adenocarcinoma NOS (morphologic abnormality)",
          "infiltrating and papillary adenocarcinoma",
          "infiltrating papillary adenocarcinoma"
        ],
        "definition": "A morphologic variant of adenocarcinoma. It is characterized by the presence of a papillary growth pattern. Representative examples include thyroid gland papillary carcinoma, invasive papillary breast carcinoma, and ovarian serous surface papillary adenocarcinoma."
      },
      "child_count": 22,
      "reference_id": "MONDO:0002512"
    },
    {
      "id": 4983,
      "label": "papillary squamous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        8000
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4385",
          "ICDO:8052/3",
          "MEDGEN:83115",
          "NCIT:C4102",
          "UMLS:C0334244"
        ],
        "synonyms": [
          "papillary epidermoid carcinoma",
          "papillary epidermoid cell carcinoma",
          "papillary squamous carcinoma",
          "papillary squamous cell carcinoma"
        ],
        "definition": "A well differentiated squamous cell carcinoma characterized by a papillary, exophytic growth pattern and hyperkeratosis. The most commonly affected anatomic sites are the larynx, penis, cervix, vagina, and vulva."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002979"
    },
    {
      "id": 7876,
      "label": "papillary transitional cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7972,
        8000
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4012",
          "EFO:1000450",
          "GARD:0024378",
          "ICDO:8130/3",
          "MEDGEN:137736",
          "NCIT:C4122",
          "UMLS:C0334274"
        ],
        "synonyms": [
          "papillary transitional carcinoma",
          "papillary transitional cell carcinoma (morphologic abnormality)"
        ],
        "definition": "A non-invasive or invasive transitional cell carcinoma characterized by a papillary growth pattern. It may occur in the bladder or the renal pelvis."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006350"
    },
    {
      "id": 16831,
      "label": "papillary carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6929,
        7594,
        8000
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020481",
          "MEDGEN:1805139",
          "Orphanet:213726",
          "UMLS:C5679804"
        ],
        "synonyms": [
          "body of uterus papillary carcinoma",
          "endometrial capillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A papillary carcinoma that involves the body of uterus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016268"
    },
    {
      "id": 16844,
      "label": "papillary carcinoma of the cervix uteri",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6855,
        8000
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020497",
          "Orphanet:213817"
        ],
        "synonyms": [
          "cervical papillary carcinoma",
          "uterine cervix papillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A papillary carcinoma that involves the uterine cervix."
      },
      "child_count": 2,
      "reference_id": "MONDO:0016285"
    }
  ],
  "roots": [
    {
      "id": 6734,
      "label": "carcinoma"
    },
    {
      "id": 20336,
      "label": "papillary epithelial neoplasm"
    }
  ]
}