{
  "id": 8005,
  "label": "childhood malignant neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006517",
  "properties": {
    "xrefs": [
      "EFO:1000654",
      "MEDGEN:82962",
      "NCIT:C4005",
      "UMLS:C0278704"
    ],
    "synonyms": [
      "childhood cancer",
      "childhood malignant neoplasm",
      "childhood neoplasm, malignant",
      "malignant childhood neoplasm",
      "malignant childhood tumor",
      "malignant childhood tumour",
      "malignant paediatric neoplasm",
      "malignant paediatric tumour",
      "malignant pediatric neoplasm",
      "malignant pediatric tumor",
      "paediatric cancer",
      "pediatric cancer",
      "malignant neoplasm"
    ],
    "definition": "A malignant tumor that occurs in children. Representative examples include soft tissue and bone sarcomas (e.g. osteosarcoma) and embryonal neoplasms (e.g. hepatoblastoma and rhabdoid tumor)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 30,
  "parents": [
    {
      "id": 6733,
      "label": "cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050686",
          "DOID:0050687",
          "DOID:162",
          "ICD9:195.8",
          "ICD9:199",
          "ICD9:199.1",
          "ICDO:8000/3",
          "MEDGEN:14297",
          "NCIT:C9305",
          "ONCOTREE:MT",
          "SCTID:363346000",
          "UMLS:C0006826",
          "birnlex:406"
        ],
        "synonyms": [
          "CA",
          "cancer",
          "cell type cancer",
          "malignancy",
          "malignant growth",
          "malignant neoplasm",
          "malignant neoplasm (disease)",
          "malignant neoplastic disease",
          "malignant tumor",
          "malignant tumour",
          "neoplasm (disease), malignant",
          "neoplasm, malignant",
          "MT"
        ],
        "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas."
      },
      "child_count": 33,
      "reference_id": "MONDO:0004992"
    },
    {
      "id": 20320,
      "label": "childhood neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:237153",
          "NCIT:C6283",
          "UMLS:C1368871"
        ],
        "synonyms": [
          "childhood neoplasm",
          "childhood neoplasm (disease)",
          "childhood tumor",
          "childhood tumour",
          "neoplasm (disease) of childhood",
          "paediatric neoplasm",
          "paediatric neoplasm (disease)",
          "paediatric tumour",
          "pediatric neoplasm",
          "pediatric neoplasm (disease)",
          "pediatric tumor"
        ],
        "definition": "A benign or malignant neoplasm arising during childhood."
      },
      "child_count": 14,
      "reference_id": "MONDO:0021079"
    }
  ],
  "children": [
    {
      "id": 4606,
      "label": "childhood oligodendroglioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8005,
        17158
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3183",
          "GARD:0023156",
          "MEDGEN:76116",
          "NANDO:2200089",
          "NCIT:C4045",
          "UMLS:C0280475"
        ],
        "synonyms": [
          "oligodendroglioma",
          "oligodendroglioma of childhood",
          "paediatric oligodendroglioma",
          "pediatric oligodendroglioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An oligodendroglioma that arises from the central nervous system and occurs during childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002540"
    },
    {
      "id": 4674,
      "label": "pediatric osteosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8005,
        11016
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3361",
          "MEDGEN:272464",
          "NANDO:2200048",
          "NCIT:C6585",
          "UMLS:C1332986"
        ],
        "synonyms": [
          "osteosarcoma",
          "childhood osteogenic sarcoma",
          "childhood osteosarcoma",
          "childhood osteosarcoma (disease)",
          "osteosarcoma (disease) of childhood",
          "paediatric osteosarcoma (disease)",
          "pediatric osteosarcoma",
          "pediatric osteosarcoma (disease)"
        ],
        "definition": "An osteosarcoma occurring in childhood."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002623"
    },
    {
      "id": 4725,
      "label": "pediatric fibrosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6886,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3520",
          "GARD:0023211",
          "MEDGEN:124685",
          "NANDO:2200060",
          "NCIT:C8088",
          "UMLS:C0279981"
        ],
        "synonyms": [
          "fibrosarcoma",
          "childhood fibrosarcoma",
          "pediatric fibrosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant neoplasm arising from the deep soft tissues in children. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002678"
    },
    {
      "id": 4732,
      "label": "childhood choroid plexus carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4214,
        8005,
        17176,
        21583
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3545",
          "GARD:0023214",
          "MEDGEN:901899",
          "NCIT:C124292",
          "UMLS:C1510426"
        ],
        "synonyms": [
          "childhood choroid plexus neoplasm",
          "childhood choroid plexus carcinoma",
          "choroid plexus carcinoma of childhood",
          "paediatric choroid plexus carcinoma",
          "pediatric choroid plexus carcinoma",
          "childhood choroid plexus cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A choroid plexus carcinoma that occurs during childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002685"
    },
    {
      "id": 4825,
      "label": "childhood central nervous system primitive neuroectodermal neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3043,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3870",
          "GARD:0027621",
          "MEDGEN:232347",
          "NCIT:C5961",
          "UMLS:C1332957"
        ],
        "synonyms": [
          "Central nervous system embryonal tumor, NOS",
          "central nervous system primitive neuroectodermal neoplasm of childhood",
          "childhood CNS PNET",
          "childhood CNS primitive neuroectodermal neoplasm",
          "childhood CNS primitive neuroectodermal tumor",
          "childhood CNS primitive neuroectodermal tumour",
          "childhood central nervous system PNET",
          "childhood central nervous system primitive neuroectodermal neoplasm",
          "childhood central nervous system primitive neuroectodermal tumor",
          "childhood central nervous system primitive neuroectodermal tumour",
          "childhood central primitive neuroectodermal neoplasm",
          "childhood central primitive neuroectodermal tumor",
          "childhood central primitive neuroectodermal tumour",
          "paediatric CNS PNET",
          "paediatric CNS primitive neuroectodermal neoplasm",
          "paediatric CNS primitive neuroectodermal tumour",
          "paediatric central nervous system primitive neuroectodermal neoplasm",
          "paediatric central nervous system primitive neuroectodermal tumour",
          "paediatric central primitive neuroectodermal neoplasm",
          "paediatric central primitive neuroectodermal tumour",
          "pediatric CNS PNET",
          "pediatric CNS primitive neuroectodermal neoplasm",
          "pediatric CNS primitive neuroectodermal tumor",
          "pediatric central nervous system primitive neuroectodermal neoplasm",
          "pediatric central nervous system primitive neuroectodermal tumor",
          "pediatric central primitive neuroectodermal neoplasm",
          "pediatric central primitive neuroectodermal tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A central nervous system embryonal tumor, not otherwise specified that occurs in childhood."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002798"
    },
    {
      "id": 4921,
      "label": "childhood brain stem neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4919,
        4922,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4206",
          "GARD:0027625",
          "MEDGEN:272459",
          "NCIT:C5969",
          "UMLS:C1332951"
        ],
        "synonyms": [
          "brain stem neoplasm",
          "brainstem cancer of childhood",
          "childhood brain stem neoplasm",
          "childhood brain stem tumor",
          "childhood brain stem tumour",
          "childhood brainstem cancer",
          "childhood brainstem neoplasm",
          "childhood brainstem tumor",
          "childhood brainstem tumour",
          "childhood neoplasm of brain stem",
          "childhood neoplasm of brainstem",
          "childhood neoplasm of the brain stem",
          "childhood neoplasm of the brainstem",
          "childhood tumor of brain stem",
          "childhood tumor of brainstem",
          "childhood tumor of the brain stem",
          "childhood tumor of the brainstem",
          "childhood tumour of brain stem",
          "childhood tumour of brainstem",
          "childhood tumour of the brain stem",
          "childhood tumour of the brainstem",
          "paediatric brain stem neoplasm",
          "paediatric brain stem tumour",
          "paediatric brainstem cancer",
          "paediatric brainstem neoplasm",
          "paediatric brainstem tumour",
          "paediatric neoplasm of brain stem",
          "paediatric neoplasm of brainstem",
          "paediatric neoplasm of the brain stem",
          "paediatric neoplasm of the brainstem",
          "paediatric tumour of brain stem",
          "paediatric tumour of brainstem",
          "paediatric tumour of the brain stem",
          "paediatric tumour of the brainstem",
          "pediatric brain stem neoplasm",
          "pediatric brain stem tumor",
          "pediatric brainstem cancer",
          "pediatric brainstem neoplasm",
          "pediatric brainstem tumor",
          "pediatric neoplasm of brain stem",
          "pediatric neoplasm of brainstem",
          "pediatric neoplasm of the brain stem",
          "pediatric neoplasm of the brainstem",
          "pediatric tumor of brain stem",
          "pediatric tumor of brainstem",
          "pediatric tumor of the brain stem",
          "pediatric tumor of the brainstem"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neoplasm that affects the brain stem and occurs during childhood."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002914"
    },
    {
      "id": 5015,
      "label": "pediatric angiosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8005,
        17394
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4505",
          "GARD:0023330",
          "MEDGEN:124687",
          "NCIT:C9174",
          "UMLS:C0279988"
        ],
        "synonyms": [
          "angiosarcoma",
          "angiosarcoma (disease) of childhood",
          "childhood angiosarcoma",
          "childhood angiosarcoma (disease)",
          "childhood hemangiosarcoma",
          "paediatric angiosarcoma (disease)",
          "pediatric angiosarcoma",
          "pediatric angiosarcoma (disease)",
          "pediatric hemangiosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An angiosarcoma occurring in childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003022"
    },
    {
      "id": 5034,
      "label": "pediatric mesenchymal chondrosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8005,
        8296
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4546",
          "GARD:0023342",
          "MEDGEN:232063",
          "NCIT:C27374",
          "UMLS:C1332982"
        ],
        "synonyms": [
          "mesenchymal chondrosarcoma",
          "childhood mesenchymal chondrosarcoma",
          "mesenchymal chondrosarcoma of childhood",
          "pediatric mesenchymal chondrosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A mesenchymal chondrosarcoma occurring in children."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003041"
    },
    {
      "id": 5482,
      "label": "pediatric liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6790,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5695",
          "GARD:0023571",
          "MEDGEN:83580",
          "NANDO:2200065",
          "NCIT:C8091",
          "UMLS:C0279984"
        ],
        "synonyms": [
          "liposarcoma",
          "childhood liposarcoma",
          "pediatric liposarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A rare malignant neoplasm arising from adipocytes, that occurs in children. The tumor maybe one of several histologic types including well-differentiated, dedifferentiated, myxoid/round cell, and pleomorphic liposarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003587"
    },
    {
      "id": 5546,
      "label": "pediatric lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6792,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5823",
          "GARD:0023606",
          "MEDGEN:232062",
          "NANDO:2100004",
          "NCIT:C5165",
          "UMLS:C1332979"
        ],
        "synonyms": [
          "lymphoma",
          "childhood lymphoma",
          "pediatric lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A Hodgkin or non-Hodgkin lymphoma that occurs during childhood."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003659"
    },
    {
      "id": 5575,
      "label": "childhood malignant mesenchymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5522,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5893",
          "MEDGEN:124688",
          "NCIT:C8097",
          "UMLS:C0279991"
        ],
        "synonyms": [
          "malignant mesenchymoma",
          "childhood malignant mesenchymoma",
          "malignant mesenchymoma of childhood",
          "paediatric malignant mesenchymoma",
          "pediatric malignant mesenchymoma"
        ],
        "definition": "A malignant mesenchymoma occurring in children."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003691"
    },
    {
      "id": 5760,
      "label": "pediatric myxoid chondrosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5566,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6494",
          "GARD:0023720",
          "MEDGEN:232065",
          "NCIT:C27377",
          "UMLS:C1332984"
        ],
        "synonyms": [
          "childhood myxoid chondrosarcoma",
          "myxoid chondrosarcoma of childhood",
          "pediatric myxoid chondrosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A myxoid chondrosarcoma occurring in children."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003898"
    },
    {
      "id": 5845,
      "label": "childhood botryoid rhabdomyosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4639,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6786",
          "GARD:0023765",
          "MEDGEN:232054",
          "NCIT:C35574",
          "UMLS:C1332944"
        ],
        "synonyms": [
          "botryoid-type embryonal rhabdomyosarcoma",
          "botryoid rhabdomyosarcoma of childhood",
          "childhood botryoid-type embryonal rhabdomyosarcoma",
          "childhood sarcoma Botryoides",
          "paediatric botryoid rhabdomyosarcoma",
          "pediatric botryoid rhabdomyosarcoma"
        ],
        "definition": "A morphologic variant of embryonal rhabdomyosarcoma occurring in children. The tumor arises from organs with a mucosal epithelial surface. It is characterized by the formation of a cambium layer in the affected tissue and polypoid nodules within an abundant myxoid stroma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003992"
    },
    {
      "id": 5886,
      "label": "pediatric intraocular retinoblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5064,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6938",
          "GARD:0023789",
          "MEDGEN:230836",
          "NCIT:C9047",
          "UMLS:C1321869"
        ],
        "synonyms": [
          "intraocular retinoblastoma",
          "childhood intraocular retinoblastoma",
          "intraocular retinoblastoma of childhood",
          "pediatric intraocular retinoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Retinoblastoma during childhood that has not spread beyond the eye."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004045"
    },
    {
      "id": 5909,
      "label": "childhood cerebral astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4578,
        4768,
        7155,
        8005,
        20689
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7007",
          "GARD:0009302",
          "MEDGEN:137828",
          "NCIT:C4347",
          "UMLS:C0338070"
        ],
        "synonyms": [
          "cerebral astrocytoma",
          "childhood astrocytic tumor of telencephalon",
          "childhood astrocytic tumour of telencephalon",
          "childhood astrocytoma of cerebrum",
          "childhood astrocytoma of the cerebrum",
          "paediatric astrocytoma of cerebrum",
          "paediatric astrocytoma of the cerebrum",
          "paediatric cerebral astrocytoma",
          "pediatric astrocytoma of cerebrum",
          "pediatric astrocytoma of the cerebrum",
          "pediatric cerebral astrocytoma",
          "telencephalon childhood astrocytic tumor",
          "telencephalon childhood astrocytic tumour",
          "telencephalon juvenile astrocytoma",
          "cerebral astrocytoma, childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An astrocytoma, without designation of benign or malignant, that is found in the supratentorial region. The infratentorial location is more common in children."
      },
      "child_count": 5,
      "reference_id": "MONDO:0004071"
    },
    {
      "id": 5939,
      "label": "childhood epithelioid sarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8005,
        17696
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7095",
          "GARD:0023826",
          "MEDGEN:76055",
          "NCIT:C8095",
          "UMLS:C0279989"
        ],
        "synonyms": [
          "epithelioid sarcoma",
          "childhood epithelioid sarcoma",
          "epithelioid sarcoma of childhood",
          "paediatric epithelioid sarcoma",
          "pediatric epithelioid sarcoma"
        ],
        "definition": "An epithelioid sarcoma occurring in childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004105"
    },
    {
      "id": 6054,
      "label": "childhood pleomorphic rhabdomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8005,
        17695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7463",
          "GARD:0023891",
          "MEDGEN:76002",
          "NCIT:C7959",
          "UMLS:C0279614"
        ],
        "synonyms": [
          "Pleomorphic rhabdomyosarcoma",
          "childhood anaplastic rhabdomyosarcoma",
          "paediatric pleomorphic rhabdomyosarcoma",
          "pediatric pleomorphic rhabdomyosarcoma",
          "pleomorphic childhood rhabdomyosarcoma",
          "pleomorphic rhabdomyosarcoma of childhood"
        ],
        "definition": "A rare aggressive rhabdomyosarcoma occurring in children. The neoplasm is characterized by the presence of bizarre round, spindle, and polygonal cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004233"
    },
    {
      "id": 6068,
      "label": "pediatric infratentorial ependymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4922,
        8005,
        20094
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7501",
          "GARD:0023898",
          "MEDGEN:82949",
          "NCIT:C9041",
          "UMLS:C0278599"
        ],
        "synonyms": [
          "childhood infratentorial ependymoma",
          "infratentorial ependymoma",
          "pediatric infratentorial ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An ependymoma that arises from the infratentorial region of the brain and occurs during childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004248"
    },
    {
      "id": 6069,
      "label": "pediatric supratentorial ependymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5400,
        8005,
        20096
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7502",
          "EFO:0008495",
          "GARD:0023899",
          "MEDGEN:78854",
          "NCIT:C9043",
          "UMLS:C0278650"
        ],
        "synonyms": [
          "supratentorial ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An ependymoma that arises from the supratentorial region of the brain and occurs during childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004249"
    },
    {
      "id": 6160,
      "label": "childhood malignant schwannoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8005,
        18046
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7732",
          "GARD:0023948",
          "MEDGEN:83582",
          "NCIT:C8094",
          "UMLS:C0279987"
        ],
        "synonyms": [
          "malignant peripheral nerve sheath tumor",
          "malignant peripheral nerve sheath tumour",
          "childhood MPNST",
          "childhood malignant neoplasm of peripheral nerve sheath",
          "childhood malignant neoplasm of the peripheral nerve sheath",
          "childhood malignant neurilemmoma",
          "childhood malignant peripheral nerve sheath neoplasm",
          "childhood malignant peripheral nerve sheath tumor",
          "childhood malignant peripheral nerve sheath tumour",
          "childhood malignant schwannoma",
          "childhood malignant tumor of peripheral nerve sheath",
          "childhood malignant tumor of the peripheral nerve sheath",
          "childhood malignant tumour of peripheral nerve sheath",
          "childhood malignant tumour of the peripheral nerve sheath",
          "childhood neurofibrosarcoma",
          "childhood neurogenic sarcoma",
          "paediatric MPNST",
          "paediatric malignant neoplasm of peripheral nerve sheath",
          "paediatric malignant neoplasm of the peripheral nerve sheath",
          "paediatric malignant neurilemmoma",
          "paediatric malignant peripheral nerve sheath neoplasm",
          "paediatric malignant peripheral nerve sheath tumour",
          "paediatric malignant schwannoma",
          "paediatric malignant tumour of peripheral nerve sheath",
          "paediatric malignant tumour of the peripheral nerve sheath",
          "pediatric MPNST",
          "pediatric malignant neoplasm of peripheral nerve sheath",
          "pediatric malignant neoplasm of the peripheral nerve sheath",
          "pediatric malignant neurilemmoma",
          "pediatric malignant peripheral nerve sheath neoplasm",
          "pediatric malignant peripheral nerve sheath tumor",
          "pediatric malignant schwannoma",
          "pediatric malignant tumor of peripheral nerve sheath",
          "pediatric malignant tumor of the peripheral nerve sheath"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant peripheral nerve sheath tumor occurring in children."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004345"
    },
    {
      "id": 6164,
      "label": "pediatric extraocular retinoblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5065,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7747",
          "GARD:0023951",
          "MEDGEN:230837",
          "NCIT:C9048",
          "UMLS:C1321870"
        ],
        "synonyms": [
          "extraocular retinoblastoma",
          "childhood extraocular retinoblastoma",
          "childhood metastatic retinoblastoma",
          "extraocular retinoblastoma of childhood",
          "pediatric extraocular retinoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Retinoblastoma during childhood that has spread beyond the eye."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004350"
    },
    {
      "id": 6169,
      "label": "childhood leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6789,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7757",
          "GARD:0023954",
          "MEDGEN:234132",
          "NANDO:2100002",
          "NCIT:C4989",
          "UMLS:C1332977"
        ],
        "synonyms": [
          "leukaemia",
          "leukemia",
          "childhood leukaemia (disease)",
          "childhood leukemia",
          "childhood leukemia (disease)",
          "leukaemia (disease) of childhood",
          "leukemia (disease) of childhood",
          "paediatric leukaemia (disease)",
          "pediatric leukemia (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acute or chronic leukemia that occurs during childhood."
      },
      "child_count": 6,
      "reference_id": "MONDO:0004355"
    },
    {
      "id": 6212,
      "label": "childhood precursor T-lymphoblastic lymphoma/leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5443,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7933",
          "GARD:0023982",
          "MEDGEN:232067",
          "NCIT:C5640",
          "UMLS:C1332997"
        ],
        "synonyms": [
          "childhood T lymphoblastic leukemia/lymphoma",
          "childhood precursor T-lymphoblastic lymphoma/leukemia",
          "paediatric precursor T-lymphoblastic lymphoma/leukemia",
          "pediatric precursor T-lymphoblastic lymphoma/leukemia",
          "precursor T-lymphoblastic lymphoma/leukemia of childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A T lymphoblastic leukemia/lymphoma that occurs during childhood."
      },
      "child_count": 4,
      "reference_id": "MONDO:0004403"
    },
    {
      "id": 6283,
      "label": "malignant childhood germ cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5631,
        7832,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8149",
          "GARD:0024027",
          "MEDGEN:233150",
          "NCIT:C6541",
          "UMLS:C1334574"
        ],
        "synonyms": [
          "malignant childhood germ cell neoplasm",
          "malignant paediatric germ cell tumour",
          "malignant pediatric germ cell tumor",
          "malignant childhood germ cell tumor",
          "malignant childhood germ cell tumour",
          "malignant paediatric germ cell neoplasm",
          "malignant pediatric germ cell neoplasm"
        ],
        "definition": "A malignant germ cell tumor that occurs during childhood."
      },
      "child_count": 36,
      "reference_id": "MONDO:0004479"
    },
    {
      "id": 12140,
      "label": "pleuropulmonary blastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7531,
        8005,
        23957
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4769",
          "EFO:0009052",
          "GARD:0008757",
          "ICD9:162.9",
          "ICDO:8973/3",
          "MEDGEN:266105",
          "MESH:C537516",
          "NANDO:2200080",
          "NCIT:C5669",
          "OMIM:601200",
          "ONCOTREE:PPB",
          "Orphanet:64742",
          "SCTID:707670009",
          "UMLS:C1266144"
        ],
        "synonyms": [
          "childhood pulmonary blastoma",
          "paediatric pulmonary blastoma",
          "pediatric pulmonary blastoma",
          "pleuropulmonary blastoma",
          "pleuropulmonary blastoma (morphologic abnormality)",
          "pulmonary blastoma of childhood",
          "PPB",
          "PPB familial tumor and dysplasia syndrome",
          "PPB familial tumour and dysplasia syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A malignant neoplasm affecting the lungs and/or the pleura. Pleuropulmonary blastoma is seen in children. Microscopically, the tumor may show features of chondrosarcoma, leiomyosarcoma, rhabdomyosarcoma, liposarcoma, or undifferentiated sarcoma. In approximately 25% of patients with pleuropulmonary blastoma, there are other lesions or neoplasms that may affect patients or their families, including lung or kidney cysts, and ovarian or testicular neoplasms. Heterozygous germline mutations in DICER1 gene have been identified in families harboring pleuropulmonary blastomas."
      },
      "child_count": 12,
      "reference_id": "MONDO:0011014"
    },
    {
      "id": 18219,
      "label": "pediatric hepatocellular carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8005,
        8660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070322",
          "GARD:0009331",
          "MEDGEN:75999",
          "NCIT:C7955",
          "Orphanet:33402",
          "UMLS:C0279606"
        ],
        "synonyms": [
          "hepatocellular cancer",
          "Paediatric carcinoma of the liver cell",
          "Pediatric carcinoma of the liver cell",
          "childhood carcinoma of the liver cell",
          "childhood hepatocellular carcinoma",
          "childhood-onset HCC",
          "childhood-onset hepatocellular carcinoma",
          "paediatric HCC",
          "pediatric HCC",
          "childhood carcinoma of liver cell",
          "childhood hepatoma",
          "childhood liver cell carcinoma",
          "paediatric carcinoma of liver cell",
          "paediatric hepatoma",
          "paediatric liver cell carcinoma",
          "pediatric carcinoma of liver cell",
          "pediatric hepatoma",
          "pediatric liver cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Pediatric hepatocellular carcinoma (pediatric HCC) is a rare, aggressive, malignant hepatic tumor that develops mainly in children over 10 years of age."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018055"
    },
    {
      "id": 22942,
      "label": "childhood malignant kidney neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4465,
        4767,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:904186",
          "NCIT:C123907",
          "UMLS:C4086162"
        ],
        "synonyms": [
          "childhood kidney cancer",
          "childhood malignant kidney neoplasm",
          "childhood malignant kidney tumor",
          "childhood malignant kidney tumour",
          "childhood malignant renal neoplasm",
          "childhood malignant renal tumor",
          "childhood malignant renal tumour",
          "kidney cancer of childhood",
          "paediatric kidney cancer",
          "pediatric kidney cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A malignant neoplasm that affects the kidney and occurs in childhood."
      },
      "child_count": 9,
      "reference_id": "MONDO:0036511"
    },
    {
      "id": 23067,
      "label": "childhood malignant melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6832,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0000091",
          "MEDGEN:1374316",
          "NCIT:C131506",
          "UMLS:C4329660"
        ],
        "synonyms": [
          "childhood melanoma",
          "childhood melanoma (disease)",
          "melanoma (disease) of childhood",
          "paediatric melanoma (disease)",
          "pediatric melanoma (disease)",
          "malignant melanoma, childhood"
        ],
        "definition": "A melanoma that occurs during childhood."
      },
      "child_count": 2,
      "reference_id": "MONDO:0042494"
    },
    {
      "id": 23478,
      "label": "extrarenal rhabdoid tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4765,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025921",
          "MEDGEN:224918",
          "NCIT:C6586",
          "SCTID:404089007",
          "UMLS:C1304517"
        ],
        "synonyms": [
          "extrarenal rhabdoid tumor",
          "malignant extrarenal rhabdoid neoplasm",
          "rhabdoid tumor of soft tissue",
          "rhabdoid tumour of soft tissue"
        ],
        "definition": "A rhabdoid tumor which arises in the soft tissues. It occurs in infants and children and may be associated with loss of chromosome 22. It is characterized by the presence of cells with a large eccentric nucleus, prominent nucleolus, and abundant cytoplasm."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044916"
    },
    {
      "id": 26452,
      "label": "pediatric high-grade glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8005,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027222",
          "MEDGEN:1861427",
          "NCIT:C202298",
          "UMLS:C5908419"
        ],
        "synonyms": [
          "childhood malignant glioma",
          "pHGG"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant high-grade glioma that occurs during childhood in the central nervous system."
      },
      "child_count": 2,
      "reference_id": "MONDO:1010030"
    }
  ],
  "roots": [
    {
      "id": 6733,
      "label": "cancer"
    },
    {
      "id": 20320,
      "label": "childhood neoplasm"
    }
  ]
}