{
  "id": 8047,
  "label": "keratosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006566",
  "properties": {
    "xrefs": [
      "DOID:161",
      "EFO:1000720",
      "MEDGEN:9625",
      "MESH:D007642",
      "NCIT:C34745",
      "SCTID:254666005",
      "UMLS:C0022593"
    ],
    "synonyms": [
      "keratoderma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A skin disorder consisting of hypertrophy of the stratum corneum of the skin."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 6820,
      "label": "skin disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4198
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:37",
          "EFO:0000701",
          "ICD9:702",
          "ICD9:702.8",
          "ICD9:709.8",
          "MEDGEN:20777",
          "MESH:D012871",
          "NANDO:2100281",
          "NCIT:C3371",
          "SCTID:95320005",
          "UMLS:C0037274"
        ],
        "synonyms": [
          "cutaneous disorder",
          "disease of zone of skin",
          "disease or disorder of zone of skin",
          "disorder of skin",
          "disorder of zone of skin",
          "skin diseases and manifestations",
          "skin disorder",
          "zone of skin disease",
          "zone of skin disease or disorder",
          "dermatosis",
          "genodermatosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs."
      },
      "child_count": 72,
      "reference_id": "MONDO:0005093"
    },
    {
      "id": 23507,
      "label": "keratinization disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4198,
        20383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:635020",
          "SCTID:277905003",
          "UMLS:C0475811"
        ],
        "synonyms": [
          "disorder of keratinization",
          "keratinization disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 4,
      "reference_id": "MONDO:0045011"
    }
  ],
  "children": [
    {
      "id": 2737,
      "label": "keratosis follicularis spinulosa decalvans",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8047,
        18791,
        24863
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080753",
          "GARD:0006829",
          "ICD9:757.39",
          "MEDGEN:83355",
          "NORD:1288",
          "Orphanet:2340",
          "SCTID:238626006",
          "UMLS:C0343057",
          "icd11.foundation:303213910"
        ],
        "synonyms": [
          "keratosis pilaris decalvans"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Keratosis follicularis spinulosa decalvans is a rare genodermatosis occurring during infancy or childhood, predominantly affecting males, and characterized by diffuse follicular hyperkeratosis associated with progressive cicatricial alopecia of the scalp, eyebrows and eyelashes. Additional findings can include photophobia, corneal dystrophy, facial erythema, and/or palmoplantar keratoderma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0000136"
    },
    {
      "id": 8009,
      "label": "acquired keratosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8047
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13072",
          "ICD9:701.1",
          "MEDGEN:44016",
          "NCIT:C34746",
          "SCTID:400166009",
          "UMLS:C0022581"
        ],
        "synonyms": [
          "acquired keratoderma",
          "acquired keratosis",
          "keratoderma, acquired",
          "acquired hyperkeratosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Focal or diffuse thickening of the skin not inherited as a primary genetic disorder. Causes include inflammatory skin disorders, infectious disorders, lymphedema, and medications."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006522"
    },
    {
      "id": 8016,
      "label": "cholesteatoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8047
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:869",
          "EFO:1000675",
          "HP:0009797",
          "ICD9:385.30",
          "MEDGEN:3043",
          "MESH:D002781",
          "NCIT:C2944",
          "SCTID:363668000",
          "UMLS:C0008373"
        ],
        "synonyms": [
          "cholesteatoma",
          "cholesteatoma (disease)",
          "congenital cholesteatoma (type)",
          "primary acquired cholesteatoma (type)",
          "secondary acquired cholesteatoma (type)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A pathologic process characterized by the proliferation of keratinizing squamous epithelium resulting in the accumulation of keratin and cells in the middle ear and/or mastoid. It may be congenital or acquired. If left untreated, it may increase in size and destroy adjacent structures."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006530"
    },
    {
      "id": 8066,
      "label": "palmoplantar keratosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8047
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3390",
          "EFO:1000745",
          "ICD9:757.39",
          "MEDGEN:44017",
          "NCIT:C34748",
          "SCTID:706885006",
          "UMLS:C0022596"
        ],
        "synonyms": [
          "palmoplantar keratoderma",
          "keratoderma, palmoplantar"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A group of autosomal dominant, autosomal recessive, X-linked inherited or acquired disorders characterized by the thickening of the palms and soles due to hyperkeratosis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006590"
    },
    {
      "id": 8077,
      "label": "porokeratosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8047,
        19129,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3805",
          "EFO:1000757",
          "GARD:0018989",
          "HP:0200044",
          "ICD9:757.39",
          "MEDGEN:56518",
          "MESH:D017499",
          "MedDRA:10036175",
          "NCIT:C85019",
          "OMIMPS:175800",
          "Orphanet:79358",
          "SCTID:400080004",
          "UMLS:C0162839",
          "Wikipedia:Porokeratosis",
          "icd11.foundation:29524620"
        ],
        "synonyms": [
          "porokeratosis",
          "porokeratosis (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A clonal proliferation of abnormal keratinocytes characterized by the development of localized or multiple atrophic skin patches surrounded by an annular keratotic ring called cornoid lamella."
      },
      "child_count": 12,
      "reference_id": "MONDO:0006602"
    },
    {
      "id": 8465,
      "label": "hereditary papulotranslucent acrokeratoderma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8047,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060360",
          "EFO:1000708",
          "MEDGEN:350144",
          "MESH:C566323",
          "OMIM:101840",
          "UMLS:C1863343"
        ],
        "synonyms": [
          "acrokeratoderma, hereditary papulotranslucent"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A keratosis of the hands and feet characterized by persistent, asymptomatic, yellowish to white papules and plaques associated with fine-textured scalp hair and an atopic diathesis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007046"
    },
    {
      "id": 8467,
      "label": "acrokeratosis verruciformis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8047,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050606",
          "EFO:1000666",
          "GARD:0016707",
          "ICD9:757.39",
          "MEDGEN:75589",
          "MedDRA:10069445",
          "NCIT:C27519",
          "OMIM:101900",
          "Orphanet:79151",
          "SCTID:400085009",
          "UMLS:C0265971"
        ],
        "synonyms": [
          "AKV of Hopf",
          "Hopf disease",
          "acrokeratosis verruciformis",
          "acrokeratosis verruciformis of Hopf",
          "AKV"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A rare genetic skin keratinization disorder with an autosomal dominant mode of inheritance. It is characterized by numerous flesh-colored warty papules on the back of the hands, medial aspect of the feet, knees, and elbows."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007048"
    },
    {
      "id": 9715,
      "label": "seborrheic keratosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8047,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6498",
          "EFO:0005584",
          "ICD10CM:L82",
          "ICD9:702.1",
          "MEDGEN:5957",
          "MESH:D017492",
          "NCIT:C9006",
          "OMIM:182000",
          "SCTID:398838000",
          "UMLS:C0022603",
          "Wikipedia:Seborrheic_keratosis"
        ],
        "synonyms": [
          "basal cell papilloma",
          "keratosis Seborrheica",
          "keratosis, seborrheic, somatic",
          "keratosis, seborrheic"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A common benign skin neoplasm usually affecting older individuals. The lesions usually are multiple and arise in the face, chest, and shoulders. They appear as black or brown, slightly elevated skin lesions."
      },
      "child_count": 10,
      "reference_id": "MONDO:0008420"
    },
    {
      "id": 23162,
      "label": "trichostasis spinulosa",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4924,
        8047
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:82669",
          "MESH:C536558",
          "SCTID:21049007",
          "UMLS:C0263487",
          "icd11.foundation:509265047"
        ],
        "synonyms": [
          "trichostasis spinulosa",
          "elevated dark spiny papules on the face or trunk"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Trichostasis spinulosa (TS) is a condition where instead of one hair protruding from a hair follicle, a bundle or bush of hair come out of a single follicle. This results in elevated, dark spiny papules on the head, face (usually the nose), and trunk. In this condition, there are numerous tiny open pores filled with multiple tiny short hairs, usually only visible with a magnifying glass. TS usually does not cause problems andmay only be noticed as an incidental finding. The exact cause is unknown."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043206"
    }
  ],
  "roots": [
    {
      "id": 6820,
      "label": "skin disorder"
    },
    {
      "id": 23507,
      "label": "keratinization disease"
    }
  ]
}