{
  "id": 8066,
  "label": "palmoplantar keratosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006590",
  "properties": {
    "xrefs": [
      "DOID:3390",
      "EFO:1000745",
      "ICD9:757.39",
      "MEDGEN:44017",
      "NCIT:C34748",
      "SCTID:706885006",
      "UMLS:C0022596"
    ],
    "synonyms": [
      "palmoplantar keratoderma",
      "keratoderma, palmoplantar"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A group of autosomal dominant, autosomal recessive, X-linked inherited or acquired disorders characterized by the thickening of the palms and soles due to hyperkeratosis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 8047,
      "label": "keratosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820,
        23507
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:161",
          "EFO:1000720",
          "MEDGEN:9625",
          "MESH:D007642",
          "NCIT:C34745",
          "SCTID:254666005",
          "UMLS:C0022593"
        ],
        "synonyms": [
          "keratoderma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A skin disorder consisting of hypertrophy of the stratum corneum of the skin."
      },
      "child_count": 18,
      "reference_id": "MONDO:0006566"
    }
  ],
  "children": [
    {
      "id": 19132,
      "label": "hereditary palmoplantar keratoderma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8066,
        19129,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018988",
          "ICD9:757.39",
          "MEDGEN:590657",
          "Orphanet:79357",
          "SCTID:239066003",
          "UMLS:C0406757",
          "icd11.foundation:1941547119"
        ],
        "synonyms": [
          "hereditary PPK",
          "hereditary keratosis palmoplantaris",
          "hereditary palmoplantar hyperkeratosis",
          "hereditary palmoplantar keratosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An instance of palmoplantar keratosis that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 24,
      "reference_id": "MONDO:0019272"
    },
    {
      "id": 23385,
      "label": "aquagenic palmoplantar keratoderma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8066,
        19129
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012991",
          "MEDGEN:1789947",
          "Orphanet:498359",
          "UMLS:C4087301"
        ],
        "synonyms": [
          "aquagenic keratoderma",
          "aquagenic palmoplantar keratoderma",
          "aquagenic syringeal acrokeratoderma",
          "aquagenic wrinkling of the palms",
          "transient reactive papulotranslucent acrokeratoderma",
          "Transient reactive papulotranslucent acrokeratoderma",
          "aquagenic wrinkling of the hands"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Aquagenic syringeal acrokeratoderma is a rare condition affecting the palms of the hands. It is characterized by the appearance or worsening of a palmar eruption, following brief exposure to water. The palmar eruption is made up of small, white or shining pimples that can conjoin into plaques. The feet are unaffected. Symptoms include a burning pain and a tightening sensation in the palms, as well as too much sweating. There are two variants. Most commonly, it is a temporary and recurrent condition that appears after submersion in water, known as the bhand in the bucket sign,b that gets better within minutes to hours of drying. A less common variant is characterized by persistent lesions that are worsened after water submersion. The cause of aquagenic syringeal acrokeratoderma is unknown, but likely relates to sweating. Several studies have found that it is present in about 40% to 84% of cystic fibrosis patients and also in carriers, which suggest that it may be caused by mutations in the CFTR gene. It is more often found in young women. Besides cystic fibrosis, it is also seen in wasting (marasmus) and nephrotic syndrome and also with the use of aspirin and other drugs such as rofecoxib and celecoxib. In most cases it does not need any treatment and resolves spontaneously. When necessary, it can be treated with topical aluminum chloride or salicylic acid ointment or with tap water iontophoresis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044663"
    }
  ],
  "roots": [
    {
      "id": 8047,
      "label": "keratosis"
    }
  ]
}