{
  "id": 8092,
  "label": "vesiculobullous skin disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006617",
  "properties": {
    "xrefs": [
      "DOID:2731",
      "EFO:1000774",
      "MEDGEN:20778",
      "MESH:D012872",
      "UMLS:C0037275"
    ],
    "synonyms": [
      "vesiculobullous skin disease",
      "Sneddon Wilkinson disease",
      "Sneddon-Wilkinson disease",
      "skin diseases, vesicular",
      "subcorneal pustular dermatoses",
      "subcorneal pustular dermatosis",
      "bullous dermatoses",
      "bullous skin disease",
      "bullous skin diseases",
      "dermatoses, bullous",
      "dermatoses, subcorneal pustular",
      "dermatoses, vesiculobullous",
      "dermatosis, subcorneal pustular",
      "pustular dermatoses, subcorneal",
      "pustular dermatosis, subcorneal",
      "skin disease, bullous",
      "skin disease, vesicular",
      "skin disease, vesiculobullous",
      "skin diseases, bullous",
      "vesicular skin disease",
      "vesicular skin diseases",
      "vesiculobullous dermatoses",
      "vesiculobullous skin diseases"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 6820,
      "label": "skin disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4198
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:37",
          "EFO:0000701",
          "ICD9:702",
          "ICD9:702.8",
          "ICD9:709.8",
          "MEDGEN:20777",
          "MESH:D012871",
          "NANDO:2100281",
          "NCIT:C3371",
          "SCTID:95320005",
          "UMLS:C0037274"
        ],
        "synonyms": [
          "cutaneous disorder",
          "disease of zone of skin",
          "disease or disorder of zone of skin",
          "disorder of skin",
          "disorder of zone of skin",
          "skin diseases and manifestations",
          "skin disorder",
          "zone of skin disease",
          "zone of skin disease or disorder",
          "dermatosis",
          "genodermatosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs."
      },
      "child_count": 72,
      "reference_id": "MONDO:0005093"
    }
  ],
  "children": [
    {
      "id": 6941,
      "label": "cellulitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8092,
        21329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3488",
          "EFO:0003035",
          "HP:0100658",
          "ICD10WHO:L03",
          "ICD9:682.8",
          "ICD9:682.9",
          "MEDGEN:40174",
          "MESH:D002481",
          "NCIT:C26715",
          "SCTID:128045006",
          "UMLS:C0007642",
          "Wikipedia:Cellulitis"
        ],
        "synonyms": [
          "cellulitis",
          "cellulitis (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Inflammation of the dermis and subcutaneous tissues caused by a bacterial infection. Symptoms include erythema, edema, and pain to the affected area."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005230"
    },
    {
      "id": 7250,
      "label": "herpes zoster",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7249,
        8092,
        20721,
        21328,
        24063
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8536",
          "EFO:0006510",
          "ICD10CM:B02",
          "ICD9:053",
          "MEDGEN:42437",
          "MESH:D006562",
          "NCIT:C71079",
          "SCTID:4740000",
          "UMLS:C0019360"
        ],
        "synonyms": [
          "Zoster",
          "herpes Zoster",
          "shingles",
          "postherpetic neuralgia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A common dermal and neurologic disorder caused by reactivation of the varicella-zoster virus that has remained dormant within dorsal root ganglia, often for decades, after the patient's initial exposure to the virus in the form of varicella (chickenpox). It is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area."
      },
      "child_count": 15,
      "reference_id": "MONDO:0005609"
    },
    {
      "id": 7331,
      "label": "chickenpox",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7249,
        8092,
        21328
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8659",
          "EFO:0007204",
          "ICD10CM:B01",
          "ICD9:052",
          "ICD9:052.9",
          "MEDGEN:2995",
          "MESH:D002644",
          "NCIT:C97132",
          "SCTID:38907003",
          "UMLS:C0008049"
        ],
        "synonyms": [
          "Varicella",
          "chicken pox",
          "chicken pox infection",
          "chickenpox",
          "varicella"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A contagious childhood disorder caused by the varicella zoster virus. It is transmitted via respiratory secretions and contact with chickenpox blister contents. It presents with a vesicular skin rash, usually associated with fever, headache, and myalgias. The pruritic fluid-filled vesicles occur 10-21 days after exposure and last for 3-4 days. An additional 3-4 days of malaise follows before the affected individual feels better. An individual is contagious 1-2 days prior to the appearance of the blisters until all blisters are crusted over. Generally, healthy individuals recover without complications."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005700"
    },
    {
      "id": 7387,
      "label": "gas gangrene",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2838,
        6940,
        8092,
        21153,
        21329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9159",
          "EFO:0007279",
          "GARD:0024229",
          "ICD10CM:A48.0",
          "ICD9:040.0",
          "MEDGEN:8959",
          "MESH:D005738",
          "SCTID:80466000",
          "UMLS:C0017105",
          "icd11.foundation:1920227791"
        ],
        "synonyms": [
          "gas gangrene",
          "myonecrosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus clostridium. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005767"
    },
    {
      "id": 8025,
      "label": "epidermolysis bullosa",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2730",
          "EFO:1000690",
          "GARD:0006359",
          "ICD10CM:Q81",
          "ICD10WHO:Q81",
          "ICD9:757.39",
          "MEDGEN:41832",
          "MESH:D004820",
          "NANDO:1200234",
          "NANDO:2100284",
          "NANDO:2201000",
          "NCIT:C67383",
          "SCTID:61003004",
          "UMLS:C0014527",
          "Wikipedia:Epidermolysis_bullosa"
        ],
        "synonyms": [
          "epidermolysis bullosa",
          "EB"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Epidermolysis bullosa (EB) is a group of genetic skin diseases that cause the skin to blister very easily. Blisters form in response to minor injuries or friction, such as rubbing or scratching. There are four main types of epidermolysis bullosa: dystrophic epidermolysis bullosa Epidermolysis bullosa simplex Junctional epidermolysis bullosa Kindler Syndrome Identifying the exact type can be hard because there are many subtypes of EB. Within each type or subtype, a person may be mildly or severely affected. The disease can range from being a minor inconvenience to completely disabling, and fatal in some cases. Most types of EB are inherited. The inheritance pattern may be autosomal dominant or autosomal recessive. Management involves protecting the skin, reducing friction against the skin, and keeping the skin cool."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006541"
    },
    {
      "id": 19177,
      "label": "autoimmune bullous skin disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4496,
        8092,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8502",
          "EFO:0008598",
          "GARD:0019028",
          "ICD9:694.8",
          "ICD9:694.9",
          "MEDGEN:1842418",
          "Orphanet:79669",
          "SCTID:7231009",
          "UMLS:C5681494"
        ],
        "synonyms": [
          "bullous skin disease",
          "bullous dermatosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An autoimmune disease characterized by blisters on the skin."
      },
      "child_count": 33,
      "reference_id": "MONDO:0019337"
    },
    {
      "id": 21125,
      "label": "eosinophilic pustular folliculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8035,
        8092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008534",
          "ICD9:704.8",
          "MEDGEN:140800",
          "MESH:C535953",
          "SCTID:95333004",
          "UMLS:C0406305",
          "icd11.foundation:1653155576"
        ],
        "synonyms": [
          "EPF",
          "Ofuji disease",
          "Ofuji's disease",
          "eosinophilic folliculitis",
          "eosinophilic folliculitis, pustular"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Eosinophilic pustular folliculitis (EPF) is a skin disorder characterized by recurring itchy, red or skin-colored bumps and pustules (bumps containing pus). The condition is named after the fact that skin biopsies of this disorder find eosinophils (a type of immune cell) around hair follicles. The papules mostly appear on the face, scalp, neck and trunk and may persist for weeks or months. EPF affects males more than females.There are several variants of EPF includingclassic eosinophilic pustular folliculitis (mainly occurring in adults in Japan); HIV-associated EPF, also referred to as immunosuppression-associated EPF; and infantile EPF (with onset from birth or within the first year of life). Whether these are distinct disorders rather than variants of one disorder is controversial, partly because the underlying cause of EFP is not known.Several treatments have been described with variable results, including various oral or topical medications and phototherapy. In patients with HIV-associated disease, antiretroviral therapy tends to greatly diminish symptoms or even eliminate the condition."
      },
      "child_count": 2,
      "reference_id": "MONDO:0023076"
    },
    {
      "id": 23176,
      "label": "papular urticaria",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7148,
        8092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:78091",
          "MESH:C537169",
          "SCTID:55608001",
          "UMLS:C0263352",
          "icd11.foundation:1014677494"
        ],
        "synonyms": [
          "papular urticaria",
          "prurigo simplex",
          "bullous papular urticaria - type",
          "lichen urticatus",
          "strophulus",
          "urticaria papulosa of hebra"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0043254"
    }
  ],
  "roots": [
    {
      "id": 6820,
      "label": "skin disorder"
    }
  ]
}