{
  "id": 8093,
  "label": "vibratory urticaria",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006618",
  "properties": {
    "xrefs": [
      "DOID:1554",
      "EFO:1000775",
      "ICD10CM:L50.4",
      "ICD9:708.4",
      "MEDGEN:510413",
      "SCTID:51247001",
      "UMLS:C0157743",
      "Wikipedia:Urticaria#Vibratory_angioedema"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "This very rare form of angioedema develops in reply to contact with vibration. In vibratory angioedema, symptoms develop within two to five minutes after contact with vibration and dissolve after about an hour. Patients with this disorder do not suffer from dermographism or pressure urticaria. Vibratory angioedema is diagnosed by holding a vibrating device such as a laboratory vortex machine against the forearm for four minutes. Speedy swelling of the whole forearm extending into the upper arm is also noted later. The principal treatment is avoidance of vibratory stimulants. Antihistamines have also been proven helpful."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 8075,
      "label": "physical urticaria",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7148
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060220",
          "EFO:1000754",
          "MEDGEN:1639813",
          "SCTID:402601007",
          "UMLS:C4551831"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A distinct subgroup of the urticaria that are induced by an exogenous physical stimulus rather than occurring spontaneously."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006599"
    }
  ],
  "children": [
    {
      "id": 8837,
      "label": "autosomal dominant vibratory urticaria",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2903,
        8093,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009806",
          "ICD9:995.1",
          "MESH:C536347",
          "OMIM:125630",
          "OMIM:193050",
          "Orphanet:493342",
          "SCTID:238694002"
        ],
        "synonyms": [
          "angioedema, vibratory",
          "vibratory angioedema",
          "DDU",
          "VBU",
          "dermodistortive urticaria",
          "vibratory urticaria, autosomal dominant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An autosomal dominant disease characterized by localized hives and systemic manifestations in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007447"
    }
  ],
  "roots": [
    {
      "id": 8075,
      "label": "physical urticaria"
    }
  ]
}