{
  "id": 8197,
  "label": "empty sella syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006740",
  "properties": {
    "xrefs": [
      "DOID:3642",
      "EFO:1000914",
      "GARD:0027764",
      "ICD9:253.8",
      "MEDGEN:41766",
      "MESH:D004652",
      "MedDRA:10014567",
      "NCIT:C84686",
      "SCTID:237722004",
      "UMLS:C0014008",
      "icd11.foundation:49112094"
    ],
    "synonyms": [
      "empty sella",
      "empty sella syndrome",
      "empty sella turcica"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Empty sella syndrome (ESS) is a condition that involves the sella turcica, a bony structure at the base of the brain that protects the pituitary gland. There is a primary and secondary form of the condition. The primary form occurs when a structural defect above the pituitary gland increases pressure in the sella turcica and causes the gland to flatten. The secondary form occurs when the pituitary gland is damaged due to injury, a tumor, surgery or radiation therapy. Some people with ESS have no symptoms. People with secondary ESS may have symptoms of decreased pituitary function such as absence of menstruation, infertility, fatigue, and intolerance to stress and infection. In children, ESS may be associated with early onset of puberty, growth hormone deficiency, pituitary tumors, or pituitary gland dysfunction. Treatment focuses on the symptoms present in each person."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 5314,
      "label": "pituitary gland disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6772,
        6875,
        7209
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:53",
          "EFO:0009607",
          "ICD9:253.1",
          "ICD9:253.8",
          "ICD9:253.9",
          "MEDGEN:45934",
          "MESH:D010900",
          "NCIT:C26854",
          "SCTID:399244003",
          "UMLS:C0032002"
        ],
        "synonyms": [
          "disease of pituitary gland",
          "disease or disorder of pituitary gland",
          "disorder of pituitary gland",
          "pituitary gland disease",
          "pituitary gland disease or disorder",
          "pituitary gland disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the pituitary gland."
      },
      "child_count": 27,
      "reference_id": "MONDO:0003381"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 5314,
      "label": "pituitary gland disorder"
    }
  ]
}