{
  "id": 8202,
  "label": "endometrioid stromal sarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006745",
  "properties": {
    "xrefs": [
      "DOID:4226",
      "EFO:1000919",
      "GARD:0006339",
      "ICDO:8930/3",
      "MEDGEN:60196",
      "MESH:D018203",
      "MedDRA:10048397",
      "MedDRA:10057649",
      "NCIT:C8973",
      "NORD:1086",
      "ONCOTREE:ESS",
      "Orphanet:213711",
      "SCTID:699356008",
      "UMLS:C0206630"
    ],
    "synonyms": [
      "ESS",
      "Empty Sella Syndrome",
      "endometrial stromal sarcoma",
      "endometrial stromal sarcomas",
      "endometrioid stromal sarcoma",
      "ess",
      "sarcomas, endometrial stromal",
      "stromal sarcoma of the corpus uteri",
      "stromal sarcoma, endometrial",
      "stromal sarcoma, endometrial, malignant",
      "stromal sarcomas, endometrial"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A malignant mesenchymal neoplasm that affects the uterine corpus, and rarely, the ovaries, cervix, and vagina. In the uterine corpus it is classified as low grade or high grade endometrial stromal sarcoma. In the remainder of the anatomic sites it is classified as low grade endometrioid stromal sarcoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 5251,
      "label": "endometrial stromal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20459
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5166",
          "EFO:1000920",
          "ICD9:239.5",
          "MEDGEN:87280",
          "MESH:D036821",
          "SCTID:446887007",
          "UMLS:C0334695"
        ],
        "synonyms": [
          "endometrial stroma neoplasm",
          "endometrial stroma tumor",
          "endometrial stroma tumour",
          "endometrial stromal tumor (morphologic abnormality)",
          "endometrial stromal tumour (morphologic abnormality)",
          "neoplasm of endometrial stroma",
          "tumor of endometrial stroma",
          "tumour of endometrial stroma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Neoplasms of the endometrial stroma that sometimes involve the myometrium. These tumors contain cells that may closely or remotely resemble the normal stromal cells. Endometrial stromal neoplasms are divided into three categories: (1) benign stromal nodules; (2) low-grade stromal sarcoma, or endolymphatic stromal myosis; and (3) malignant endometrial stromal sarcoma (sarcoma, endometrial stromal)."
      },
      "child_count": 1,
      "reference_id": "MONDO:0003311"
    },
    {
      "id": 6816,
      "label": "sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1115",
          "EFO:0000691",
          "ICD9:171",
          "ICD9:171.0",
          "ICD9:171.2",
          "ICD9:171.3",
          "ICD9:171.4",
          "ICD9:171.5",
          "ICD9:171.6",
          "ICD9:171.7",
          "ICD9:171.8",
          "ICD9:171.9",
          "ICDO:8800/3",
          "MEDGEN:224714",
          "MESH:D012509",
          "NCIT:C9118",
          "SCTID:424413001",
          "UMLS:C1261473"
        ],
        "synonyms": [
          "mesenchymal tumor, malignant",
          "sarcoma",
          "sarcoma of soft tissue and bone",
          "sarcoma of the soft tissue and bone",
          "sarcoma, malignant",
          "tumor of soft tissue and skeleton",
          "tumour of soft tissue and skeleton"
        ],
        "definition": "A usually aggressive malignant neoplasm of the soft tissue or bone. It arises from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The prognosis depends largely on the degree of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma."
      },
      "child_count": 22,
      "reference_id": "MONDO:0005089"
    },
    {
      "id": 13033,
      "label": "endometrial cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4754,
        20459
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1380",
          "ICD10CM:C54.1",
          "MEDGEN:2840",
          "NCIT:C27815",
          "OMIM:608089",
          "UMLS:C0007103"
        ],
        "synonyms": [
          "endometrial neoplasm",
          "neoplasm of endometrium",
          "tumor of endometrium",
          "tumour of endometrium",
          "cancer of endometrium",
          "endometrial cancer",
          "endometrial cancer, familial, autosomal dominant, somatic mutation",
          "endometrial cancer, susceptibility to, autosomal dominant, somatic mutation",
          "endometrial carcinoma, somatic",
          "endometrium cancer",
          "malignant endometrial neoplasm",
          "malignant endometrium neoplasm",
          "malignant neoplasm of endometrium"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Primary or metastatic malignant neoplasm involving the endometrium (mucous membrane that lines the endometrial cavity)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0011962"
    }
  ],
  "children": [
    {
      "id": 4930,
      "label": "uterine corpus endometrial stromal sarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6926,
        8202
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4227",
          "GARD:0023303",
          "MEDGEN:275553",
          "NCIT:C40219",
          "UMLS:C1519849"
        ],
        "synonyms": [
          "body of uterus endometrial stromal sarcoma",
          "body of uterus endometrioid stromal sarcoma",
          "endometrioid stromal sarcoma of body of uterus",
          "uterine corpus endometrial stromal sarcoma",
          "uterine corpus endometrial stromal tumour",
          "uterine corpus ess"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A uterine corpus sarcoma originating from the endometrial stroma. It is further subdivided into low grade and high grade endometrial stromal sarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002923"
    },
    {
      "id": 5023,
      "label": "endometrioid stromal sarcoma of the cervix",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5024,
        8202,
        16839
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4520",
          "GARD:0023337",
          "MEDGEN:770966",
          "NCIT:C40220",
          "UMLS:C3642326"
        ],
        "synonyms": [
          "endometrioid stromal sarcoma of the cervix",
          "endometrioid stromal sarcoma of uterine cervix",
          "uterine cervix endometrioid stromal sarcoma",
          "cervical endometrial stromal sarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare sarcoma that arises from the cervix. This category includes low grade endometrioid stromal sarcoma and undifferentiated endocervical sarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003030"
    },
    {
      "id": 5253,
      "label": "endometrioid stromal sarcoma of the vagina",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4273,
        5254,
        8202
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5170",
          "GARD:0023442",
          "MEDGEN:770969",
          "NCIT:C40270",
          "UMLS:C3642329"
        ],
        "synonyms": [
          "endometrioid stromal sarcoma of the vagina",
          "endometrioid stromal sarcoma of vagina",
          "vagina endometrioid stromal sarcoma",
          "vaginal endometrial stromal sarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare sarcoma that arises from the vagina. This category includes low grade endometrioid stromal sarcoma and undifferentiated vaginal sarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003313"
    }
  ],
  "roots": [
    {
      "id": 5251,
      "label": "endometrial stromal tumor"
    },
    {
      "id": 6816,
      "label": "sarcoma"
    },
    {
      "id": 13033,
      "label": "endometrial cancer"
    }
  ]
}