{
  "id": 8241,
  "label": "hyperpituitarism",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006793",
  "properties": {
    "xrefs": [
      "DOID:2444",
      "EFO:1000973",
      "ICD9:253.1",
      "MEDGEN:43783",
      "MESH:D006964",
      "MedDRA:10020716",
      "SCTID:10649000",
      "UMLS:C0020506"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 21424,
      "label": "anterior pituitary gland disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:253.4",
          "ICD9:253.9",
          "MEDGEN:148306",
          "SCTID:51742006",
          "UMLS:C0751437"
        ],
        "synonyms": [
          "adenohypophysis disease",
          "adenohypophysis disease or disorder",
          "disease of adenohypophysis",
          "disease or disorder of adenohypophysis",
          "disorder of adenohypophysis",
          "disorder of anterior pituitary",
          "disorder of anterior pituitary gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease that involves the adenohypophysis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0024468"
    }
  ],
  "children": [
    {
      "id": 7420,
      "label": "hyperprolactinemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8241
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0007319",
          "HP:0000870",
          "ICD10CM:E22.1",
          "ICD9:253.1",
          "MEDGEN:5698",
          "MESH:D006966",
          "NANDO:2100115",
          "NANDO:2200322",
          "SCTID:237662005",
          "UMLS:C0020514"
        ],
        "synonyms": [
          "hyperprolactinaemia",
          "hyperprolactinemia",
          "hyperprolactinemia (disease)",
          "hyperprolactinemias",
          "hypersecretion syndrome, prolactin",
          "inappropriate prolactin secretion",
          "inappropriate prolactin secretion syndrome",
          "inappropriate secretion prolactin",
          "prolactin hypersecretion syndrome",
          "prolactin secretion, inappropriate",
          "prolactin, inappropriate secretion",
          "secretion prolactin, inappropriate",
          "secretion, inappropriate prolactin",
          "syndrome, prolactin hypersecretion"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Abnormally high level of prolactin in the blood."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005804"
    },
    {
      "id": 19653,
      "label": "acromegaly",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8241
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2449",
          "EFO:1001485",
          "GARD:0005725",
          "MEDGEN:1304",
          "MESH:D000172",
          "MedDRA:10000599",
          "NANDO:2100112",
          "NANDO:2200315",
          "NCIT:C84533",
          "NORD:723",
          "Orphanet:963",
          "SCTID:74107003",
          "UMLS:C0001206"
        ],
        "synonyms": [
          "Growth hormone excess",
          "pituitary giant",
          "somatotroph adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Acromegaly is an acquired disorder related to excessive production of growth hormone (GH) and characterized by progressive somatic disfigurement (mainly involving the face and extremities) and systemic manifestations."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019933"
    },
    {
      "id": 19936,
      "label": "pituitary gigantism",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8241,
        19647
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006506",
          "MEDGEN:6602",
          "MESH:D005877",
          "MedDRA:10018265",
          "NANDO:2100111",
          "NANDO:2200314",
          "NCIT:C93046",
          "Orphanet:99725",
          "SCTID:86073008",
          "UMLS:C0017547"
        ],
        "synonyms": [
          "hypophyseal gigantism",
          "infantile and juvenile forms of acromegaly",
          "gigantism"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "The condition of accelerated and excessive growth in children or adolescents who are exposed to excess human growth hormone before the closure of epiphyses. It is usually caused by somatotroph hyperplasia or a growth hormone-secreting pituitary adenoma. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020479"
    },
    {
      "id": 19975,
      "label": "ACTH-dependent Cushing syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8241,
        25672
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3946",
          "EFO:1001110",
          "GARD:0019699",
          "ICD10CM:E24.0",
          "MEDGEN:575036",
          "MESH:D047748",
          "MedDRA:10035109",
          "Orphanet:99892",
          "SCTID:190502001",
          "SCTID:237734007",
          "UMLS:C0342442",
          "icd11.foundation:212778081"
        ],
        "synonyms": [
          "ACTH-dependent CS",
          "adrenocorticotropic hormone-dependent Cushing syndrome",
          "corticotropin-dependent Cushing syndrome",
          "pituitary-dependent Cushing's disease",
          "ACTH hypersecretion, pituitary",
          "adrenocorticotropic hormone, inappropriate secretion",
          "pituitary Cushing disease",
          "pituitary Cushing diseases",
          "pituitary Cushing syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A group of endogenous Cushing syndrome caused by abnormal production of ACTH due to pituitary adenoma or an extrapituitary tumor."
      },
      "child_count": 4,
      "reference_id": "MONDO:0020528"
    }
  ],
  "roots": [
    {
      "id": 21424,
      "label": "anterior pituitary gland disorder"
    }
  ]
}