{
  "id": 8242,
  "label": "hypersensitivity vasculitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006794",
  "properties": {
    "xrefs": [
      "DOID:9809",
      "EFO:1000974",
      "GARD:0024475",
      "ICD9:446.2",
      "ICD9:446.20",
      "ICD9:446.29",
      "MEDGEN:445500",
      "MedDRA:10020764",
      "NCIT:C82863",
      "SCTID:60555002",
      "UMLS:C2973529"
    ],
    "synonyms": [
      "leukocytoclastic vasculitis"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A small vessel vasculitis affecting the skin and/or internal organs. It is characterized by the presence of neutrophils and fibrinoid necrosis in small arteries and venules. It may be idiopathic or the result of drug treatment, infections, food intake, collagen vascular disorders, inflammatory bowel disease, or cancer."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 3018,
      "label": "hypersensitivity reaction disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060056",
          "EFO:1002003",
          "MEDGEN:759636",
          "NCIT:C3114",
          "SCTID:473010000",
          "UMLS:C3532523"
        ],
        "synonyms": [
          "allergic reaction",
          "sensitive",
          "sensitivity",
          "hypersensitive",
          "hypersensitivity",
          "hypersensitivity reaction"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An immune system disease that has basis in dysregulation of the hypersensitivity reaction, an inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000605"
    },
    {
      "id": 18813,
      "label": "vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7065,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:865",
          "EFO:0006803",
          "GARD:0018844",
          "MEDGEN:12054",
          "MESH:D014657",
          "MedDRA:10036023",
          "MedDRA:10047115",
          "NCIT:C26912",
          "Orphanet:52759",
          "SCTID:31996006",
          "UMLS:C0042384",
          "Wikipedia:Vasculitis",
          "icd11.foundation:572581721"
        ],
        "synonyms": [
          "systemic vasculitis",
          "angiitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Vasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. Behcet disease) to relatively minor skin disease."
      },
      "child_count": 36,
      "reference_id": "MONDO:0018882"
    }
  ],
  "children": [
    {
      "id": 3523,
      "label": "allergic cutaneous vasculitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6721,
        8242,
        20014
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11450",
          "GARD:0022915",
          "MEDGEN:57718",
          "NCIT:C35119",
          "UMLS:C0151436"
        ],
        "synonyms": [
          "allergic cutaneous angiitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Inflammation of the small vessels of the skin that is mediated by the immune system."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001290"
    },
    {
      "id": 19042,
      "label": "immunoglobulin A vasculitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8242,
        16323,
        24822
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11123",
          "GARD:0008204",
          "ICD10CM:D69.0",
          "ICD9:287.0",
          "MEDGEN:48265",
          "MESH:D011695",
          "NCIT:C34963",
          "Orphanet:761",
          "SCTID:191306005",
          "SCTID:86074002",
          "UMLS:C0034152",
          "icd11.foundation:1629105375"
        ],
        "synonyms": [
          "HSP",
          "IgA vasculitis",
          "Schoenlein-Henoch purpura",
          "allergic purpura",
          "anaphylactoid purpura",
          "purpura rheumatica",
          "rheumatoid purpura",
          "Henoch Schonlein purpura",
          "purpura, Schonlein-Henoch",
          "vascular purpura"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A systemic IgA vasculitis that affects small vessels. It is characterized by skin purpura, arthritis, and abdominal and/or renal involvement."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019167"
    }
  ],
  "roots": [
    {
      "id": 3018,
      "label": "hypersensitivity reaction disease"
    },
    {
      "id": 18813,
      "label": "vasculitis"
    }
  ]
}