{
  "id": 8388,
  "label": "sebaceous adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006962",
  "properties": {
    "xrefs": [
      "DOID:4839",
      "DOID:4840",
      "EFO:1001171",
      "ICDO:8410/3",
      "MEDGEN:64632",
      "MESH:D018266",
      "NCIT:C40310",
      "ONCOTREE:SEBA",
      "SCTID:307599002",
      "UMLS:C0206684"
    ],
    "synonyms": [
      "adenocarcinoma, sebaceous, malignant",
      "carcinoma of sebaceous gland",
      "carcinoma of the sebaceous gland",
      "sebaceous cancer",
      "sebaceous carcinoma",
      "sebaceous gland adenocarcinoma",
      "sebaceous gland carcinoma",
      "malignant sebaceous tumor",
      "malignant sebaceous tumour",
      "Seba"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "An adenocarcinoma with sebaceous differentiation. It presents as a painless mass and it may be multifocal. It grows in the ocular adnexae and in the skin of head and neck, trunk, genitals, and extremities. It is characterized by the presence of malignant cells with multivesicular and clear cytoplasm. It may recur and metastasize."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    },
    {
      "id": 8398,
      "label": "skin appendage carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4406,
        4707
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001183",
          "ICDO:8390/3",
          "MEDGEN:60209",
          "MESH:D018280",
          "MedDRA:10040798",
          "NCIT:C3775",
          "ONCOTREE:SKAC",
          "UMLS:C0206697"
        ],
        "synonyms": [
          "adnexal carcinoma",
          "carcinoma of adnexa",
          "carcinoma of cutaneous appendage",
          "carcinoma of skin appendage",
          "carcinoma, adnexal, malignant",
          "cutaneous appendage carcinoma",
          "skin appendage carcinoma",
          "skin adnexal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine carcinoma, and pilomatrical carcinoma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0006973"
    },
    {
      "id": 22966,
      "label": "sebaceous gland cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4907,
        8389
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:235134",
          "NCIT:C8409",
          "UMLS:C1382026"
        ],
        "synonyms": [
          "cancer of sebaceous gland",
          "malignant neoplasm of sebaceous gland",
          "malignant neoplasm of the sebaceous gland",
          "malignant sebaceous gland neoplasm",
          "malignant sebaceous gland tumor",
          "malignant sebaceous gland tumour",
          "malignant sebaceous neoplasm",
          "malignant sebaceous tumor",
          "malignant sebaceous tumour",
          "malignant tumor of sebaceous gland",
          "malignant tumor of the sebaceous gland",
          "malignant tumour of sebaceous gland",
          "malignant tumour of the sebaceous gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A cancer that involves the sebaceous gland."
      },
      "child_count": 2,
      "reference_id": "MONDO:0037735"
    }
  ],
  "children": [
    {
      "id": 5524,
      "label": "sebaceous breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6729,
        7803,
        8388
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5760",
          "MEDGEN:276789",
          "NCIT:C40369",
          "UMLS:C1519207"
        ],
        "synonyms": [
          "breast sebaceous adenocarcinoma",
          "sebaceous adenocarcinoma of breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A very rare breast adenocarcinoma with sebaceous differentiation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003635"
    },
    {
      "id": 5525,
      "label": "vulvar sebaceous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8388,
        21365
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5761",
          "GARD:0023594",
          "MEDGEN:276996",
          "NCIT:C40309",
          "UMLS:C1520094"
        ],
        "synonyms": [
          "mammalian vulva sebaceous adenocarcinoma",
          "sebaceous adenocarcinoma of mammalian vulva"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the vulva. It is characterized by the presence of malignant basaloid glandular epithelial cells that resemble sebaceous epithelium and are arranged in cords and nests."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003636"
    },
    {
      "id": 7860,
      "label": "ocular sebaceous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4546,
        8388
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000405",
          "MEDGEN:317974",
          "NCIT:C43340",
          "UMLS:C1709308"
        ],
        "synonyms": [
          "eye sebaceous carcinoma",
          "ocular sebaceous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Ocular sebaceous carcinoma is a rare condition and accounts for 1% to 5.5% of eyelid malignancies and is the third most common eyelid malignancy after basal cell and squamous cell carcinoma. It usually affects elderly women, has a high rate of local recurrence, and a tendency to regional and distant metastases."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006327"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    },
    {
      "id": 8398,
      "label": "skin appendage carcinoma"
    },
    {
      "id": 22966,
      "label": "sebaceous gland cancer"
    }
  ]
}